Cited by 371Pain Mechanisms and TreatmentsNeuroinflammation and Neurodegeneration MechanismsPain Management and Treatment

The DOI matches its Crossref record; 50 of the 51 references it cites were found in a registry or an index.

Role of the CX3CR1/p38 MAPK pathway in spinal microglia for the development of neuropathic pain following nerve injury-induced cleavage of fractalkine

Open access

Zhuang, Zhi-Ye, Kawasaki, Yasuhiko, Tan, Ping-Heng, Wen, Yeong-Ray, Huang, Jing, Ji, Ru-Rong·2007·Brain, Behavior, and Immunity

DOI 10.1016/j.bbi.2006.11.003PMC PMC2084372

Open this paper in CoChat — free account

Abstract

Accumulating evidence suggests that microglial cells in the spinal cord play an important role in the development of neuropathic pain. However, it remains largely unknown how glia interact with neurons in the spinal cord after peripheral nerve injury. Recent studies suggest that the chemokine fractalkine may mediate neural/microglial interaction via its sole receptor CX3CR1. We have examined how fractalkine activates microglia in a neuropathic pain condition produced by spinal nerve ligation (SNL). SNL induced an upregulation of CX3CR1 in spinal microglia that began on day 1, peaked on day 3, and maintained on day 10. Intrathecal injection of a neutralizing antibody against CX3CR1 suppressed not only mechanical allodynia but also the activation of p38 MAPK in spinal microglia following SNL. Conversely, intrathecal infusion of fractalkine produced a marked p38 activation and mechanical allodynia. SNL also induced a dramatic reduction of the membrane-bound fractalkine in the dorsal root ganglion, suggesting a cleavage and release of this chemokine after nerve injury. Finally, application of fractalkine to spinal slices did not produce acute facilitation of excitatory synaptic transmission in lamina II dorsal horn neurons, arguing against a direct action of fractalkine on spinal neurons. Collectively, our data suggest that (a) fractalkine cleavage (release) after nerve injury may play an important role in neural-glial interaction, and (b) microglial CX3CR1/p38 MAPK pathway is critical for the development of neuropathic pain.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.bbi.2006.11.003

Cites

50 of 50 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Quantitative assessment of tactile allodynia in the rat paw
Chaplan, S. R., Bach, F. W., Pogrel, J. W., Chung, J. M., & Yaksh, T. L. (1994) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(94)90144-9 · Cited by 7,740
An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat
Ho Kim, S., & Mo Chung, J. (1992) · Pain · doi:10.1016/0304-3959(92)90041-9 · Cited by 3,069
Efficient Analysis of Experimental Observations
Dixon, W. J. (1980) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.20.040180.002301 · Cited by 2,216
Microglia as a source and target of cytokines
Hanisch, U. (2002) · Glia · doi:10.1002/glia.10161 · Cited by 1,645
P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury
Tsuda, M., Shigemoto‐Mogami, Y., Koizumi, S., Mizokoshi, A., Kohsaka, S., Salter, M. W., & Inoue, K. (2003) · Nature · doi:10.1038/nature01786 · Cited by 1,567
Interleukin-1β-mediated induction of Cox-2 in the CNS contributes to inflammatory pain hypersensitivity
Samad, T. A., Moore, K. A., Sapirstein, A., Billet, S. E., Allchorne, A. J., Poole, S., Bonventre, J. V., & Woolf, C. J. (2001) · Nature · doi:10.1038/35068566 · Cited by 1,282
p38 MAPK Activation by NGF in Primary Sensory Neurons after Inflammation Increases TRPV1 Levels and Maintains Heat Hyperalgesia
Ji, R., Samad, T. A., Jin, S., Schmoll, R., & Woolf, C. J. (2002) · Neuron · doi:10.1016/s0896-6273(02)00908-x · Cited by 1,239
Self-citation
Glial activation: a driving force for pathological pain
Watkins, L. R., Milligan, E. D., & Maier, S. F. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01854-3 · Cited by 1,091
p38 Mitogen-Activated Protein Kinase Is Activated after a Spinal Nerve Ligation in Spinal Cord Microglia and Dorsal Root Ganglion Neurons and Contributes to the Generation of Neuropathic Pain
Jin, S., Zhuang, Z.-Y., Woolf, C. J., & Ji, R. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-10-04017.2003 · Cited by 854
Self-citation
Inhibition of Microglial Activation Attenuates the Development but Not Existing Hypersensitivity in a Rat Model of Neuropathy
Vasudeva, R., Tanga, F. Y., & DeLeo, J. A. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.052407 · Cited by 797

Show all 51 references

Research works printed but not linked: 2

Jin, 2002, Activation of p38 MAP kinase in the dorsal root ganglion and spinal cord after spinal nerve ligation, Soc. Neurosci. Abstr., 28, 13
Kawasaki, 2006, Effects of proinflammatory cytokines on synaptic transmission and phosphorylation of the transcription factor CREB in dorsal horn neurons in spinal cord slices, Soc. Neurosci., 15

Sorted by citations

Items 201–300 of 369

Diosgenin attenuates neuropathic pain in a rat model of chronic constriction injury
Zhao, W.-X., Wang, P., Song, H.-G., & Sun, N. C. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.6723 · Cited by 29
Cdk5 contributes to inflammation-induced thermal hyperalgesia mediated by the p38 MAPK pathway in microglia.
Fang-Hu, Zhang, H.-H., Yang, B., Huang, J.-L., Shun, J., Kong, F., Peng-Xu, Chen, Z.-G., & Lu, J. (2015) · Brain Research · doi:10.1016/j.brainres.2015.01.056 · Cited by 28
Self-citation
Altered expression of glial markers, chemokines, and opioid receptors in the spinal cord of type 2 diabetic monkeys
Kiguchi, N., Ding, H., Peters, C. M., Kock, N. D., Kishioka, S., Cline, J. M., Wagner, J. D., & Ko, M. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.10.007 · Cited by 29
Intrathecal Infusion of Pyrrolidine Dithiocarbamate for the Prevention and Reversal of Neuropathic Pain in Rats Using a Sciatic Chronic Constriction Injury Model
Pan, Y., Guo, Q., Wang, E., Ye, Z., He, Z.-H., Zou, W., Cheng, Z., & Wang, Y. (2010) · Regional Anesthesia & Pain Medicine · doi:10.1097/aap.0b013e3181df245b · Cited by 28
CX3CR1-Targeted PLGA Nanoparticles Reduce Microglia Activation and Pain Behavior in Rats with Spinal Nerve Ligation
Noh, C., Shin, H. J., Lee, S., Kim, S. I., Kim, S. I., Lee, W. H., Kim, D. W., Lee, S. Y., & Ko, Y. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21103469 · Cited by 28
RETRACTED: Role of fractalkine/CX3CR1 signaling pathway in the recovery of neurological function after early ischemic stroke in a rat model
Liu, Y., Wang, C., Wang, Q., Lin, Y., Ge, Y., Li, D., & Mao, G. (2017) · Life Sciences · doi:10.1016/j.lfs.2017.06.012 · Cited by 26
Retracted
Upregulation of CXCR 4 through promoter demethylation contributes to inflammatory hyperalgesia in rats
Li, F., Xue, Z., Yuan, Y., et al. (2018) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12845 · Cited by 26
Interactions and Trends of Interleukins, PAI-1, CRP, and TNF-α in Inflammatory Responses during the Perioperative Period of Joint Arthroplasty: Implications for Pain Management—A Narrative Review
Cocea, A.-C., & Stoica, C. I. (2024) · Journal of Personalized Medicine · doi:10.3390/jpm14050537 · Cited by 32
Adenoviral-Mediated Glial Cell Line–Derived Neurotrophic Factor Gene Transfer Has a Protective Effect on Sciatic Nerve Following Constriction-Induced Spinal Cord Injury
Chou, A., Yang, M., Tsai, H., Chai, C., Tai, M., Kwan, A.-L., & Hong, Y. (2014) · PLoS ONE · doi:10.1371/journal.pone.0092264 · Cited by 25
Disruption of nNOS–NOS1AP protein–protein interactions suppresses neuropathic pain in mice
Lee, W.-H., Li, L., Chawla, A., Hudmon, A., Lai, Y. Y., Courtney, M. J., & Hohmann, A. G. (2018) · Pain · doi:10.1097/j.pain.0000000000001152 · Cited by 25
Neuroinflammation in the anterior cingulate cortex: the potential supraspinal mechanism underlying the mirror-image pain following motor fiber injury
Li, Q., Chen, S., Liu, J., Yao, P., Duan, Y.-W., Li, Y., & Zang, Y. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02525-8 · Cited by 27
Effects of curcumin on pain threshold and on the expression of nuclear factor κ B and CX3C receptor 1 after sciatic nerve chronic constrictive injury in rats
Cao, H., Zheng, J., Li, J., Meng, B., Li, J., & Ge, R.-S. (2014) · Chinese Journal of Integrative Medicine · doi:10.1007/s11655-013-1549-9 · Cited by 26
Pretreatment with intrathecal amitriptyline potentiates anti-hyperalgesic effects of post-injury intra-peritoneal amitriptyline following spinal nerve ligation
Cheng, K., Wang, H., Chang, L., Wang, F.-Y., Lai, C., Chou, C.-W., Tsai, H., & Kwan, A.-L. (2012) · BMC Neurology · doi:10.1186/1471-2377-12-44 · Cited by 25
Electroacupuncture alleviates neuropathic pain caused by spared nerve injury by promoting AMPK/mTOR-mediated autophagy in dorsal root ganglion macrophage
Xu, Q., Niu, C., Li, J., Hu, C., He, M., Qiu, X., Yao, Q., Tian, W., & Zhang, M. (2022) · Annals of Translational Medicine · doi:10.21037/atm-22-5920 · Cited by 22
The impact of mouse strain-specific spatial and temporal immune responses on the progression of neuropathic pain
Isami, K., Imai, S., Sukeishi, A., Nagayasu, K., Shirakawa, H., Nakagawa, T., & Kaneko, S. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.08.013 · Cited by 23
Implication of microglia activation and CSF1/CSF1R pathway in lumbar disc degeneration-related back pain
Yang, G., Chen, L., Gao, Z., & Wang, Y. (2018) · Molecular Pain · doi:10.1177/1744806918811238 · Cited by 23
p38 Inhibition Decreases Tau Toxicity in Microglia and Improves Their Phagocytic Function
Perea, J. R., Bolós, M., Cuadros, R., García, E., García‐Escudero, V., Hernández, F., McManus, R. M., Heneka, M. T., & Ávila, J. (2022) · Molecular Neurobiology · doi:10.1007/s12035-021-02715-0 · Cited by 24
Differential activation of mitogen-activated protein kinases and glial cells in the trigeminal sensory nuclear complex following lingual nerve injury.
Terayama, R., Fujisawa, N., Yamaguchi, D., Omura, S., Ichikawa, H., & Sugimoto, T. (2011) · Neurosciences research · doi:10.1016/j.neures.2010.11.004 · Cited by 21
New molecules for the treatment of pain
Heinzmann, S., & McMahon, S. B. (2011) · Current Opinion in Supportive and Palliative Care · doi:10.1097/spc.0b013e328345bb7e · Cited by 22
Lipomatosis-associated inflammation and excess collagen may contribute to lower relative resting energy expenditure in women with adiposis dolorosa
Herbst, K. L., Coviello, A. D., Chang, A., & Boyle, D. L. (2009) · International Journal of Obesity · doi:10.1038/ijo.2009.119 · Cited by 23
Inhibition of p38 mitogen-activated protein kinase activation in the rostral anterior cingulate cortex attenuates pain-related negative emotion in rats
Cao, H., Zang, K., Han, M., Zhao, Z., Wu, G.-C., & Zhang, Y. (2014) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2014.06.005 · Cited by 21
FBXW5 reduction alleviates spinal cord injury (SCI) by blocking microglia activity: A mechanism involving p38 and JNK
Zhao, P., Wang, C., & Li, W. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.04.086 · Cited by 21
Involvement of CX3CL1/CX3CR1 Signaling in Spinal Long Term Potentiation
Bian, C., Zhao, Z., Zhang, Y., & Lü, N. (2015) · PLoS ONE · doi:10.1371/journal.pone.0118842 · Cited by 21
Gonadotropin Stimulation of Ovarian Fractalkine Expression and Fractalkine Augmentation of Progesterone Biosynthesis by Luteinizing Granulosa Cells
Zhao, P., De, A., Hu, Z., Li, J., Mulders, S. M., Gelpke, M. D. S., Duan, E., & Hsueh, A. J. W. (2008) · Endocrinology · doi:10.1210/en.2007-1662 · Cited by 21
Advances in Neuropathic Pain Research: Selected Intracellular Factors as Potential Targets for Multidirectional Analgesics
Ciapała, K., & Mika, J. (2023) · Pharmaceuticals · doi:10.3390/ph16111624 · Cited by 20
Resveratrol attenuates bone cancer pain through the inhibition of spinal glial activation and CX 3 CR 1 upregulation
Cheng, W., Zhao, Y., Liu, H., et al. (2014) · Fundamental and Clinical Pharmacology · doi:10.1111/fcp.12084 · Cited by 19
Antinociceptive effectiveness of the inhibition of NCX reverse-mode action in rodent neuropathic pain model
Huang, Y., Wen, L.-L., Xie, J., Ouyang, H.-D., Chen, D.-T., & Zeng, W.-A. (2019) · Molecular Pain · doi:10.1177/1744806919864511 · Cited by 19
CX3CR1-Mediated Akt1 Activation Contributes to the Paclitaxel-Induced Painful Peripheral Neuropathy in Rats
Li, D., Chen, H., Luo, X.-H., Sun, Y., Xia, W. T., & Xiong, Y.-C. (2016) · Neurochemical Research · doi:10.1007/s11064-016-1827-y · Cited by 19
Targeting spinal microglia with fexofenadine-loaded nanoparticles prolongs pain relief in a rat model of neuropathic pain
Tran, Q., Phạm, T. L., Shin, H. J., Shin, J., Shin, N., Kwon, H. H., Park, H., Kim, S. I., Choi, S. G., Wu, J., et al. (2022) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2022.102576 · Cited by 18
Central Sensitization and Nociplastic Pain: Shared Mechanisms in Fibromyalgia, Osteoarthritis, and Inflammatory Arthritis
Hladkykh, F. V., Liadova, T., Matvieienko, M. S., Komorovsky, R., Smiyan, S., & Student, V. (2026) · Journal of Pain Research · doi:10.2147/jpr.s571311 · Cited by 22
Proinflammatory cytokines and their receptors as druggable targets to alleviate pathological pain
Kalpachidou, T., Riehl, L., Schöpf, C. L., Uçar, B., & Kress, M. (2022) · Pain · doi:10.1097/j.pain.0000000000002737 · Cited by 17
Daphnetin Improves Neuropathic Pain by Inhibiting the Expression of Chemokines and Inflammatory Factors in the Spinal Cord and Interfering with Glial Cell Polarization
Zhang, T., Liang, W., Zhang, M., Cui, S., Huang, X., Ou, W., Huang, R., Gao, J., Jia, Z., & Zhang, S. (2023) · Pharmaceuticals · doi:10.3390/ph16020243 · Cited by 18
Antinociceptive and neuroprotective effect of echinacoside on peripheral neuropathic pain in mice through inhibiting P2X7R/FKN/CX3CR1 pathway
Liu, N., Zhang, G., Zhu, C., Lan, X., Tian, M., Zheng, P., Peng, X.-D., Li, Y., & Yu, J. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115675 · Cited by 17
Intra-amygdala microinfusion of neuropeptide S attenuates neuropathic pain and suppresses the response of spinal microglia and astrocytes after spinal nerve ligation in rats
Yang, F., Peng, L., Luo, J., Yi, H., & Hu, X. (2016) · Peptides · doi:10.1016/j.peptides.2016.05.005 · Cited by 17
Increase in hemokinin‐1 mRNA in the spinal cord during the early phase of a neuropathic pain state
Matsumura, T., Sakai, A., Nagano, M., et al. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.301 · Cited by 16
A Functional Relationship Between Trigeminal Astroglial Activation and NR1 Expression in a Rat Model of Temporomandibular Joint Inflammation
Wang, S., Song, L., Tan, Y., et al. (2012) · Pain Medicine · doi:10.1111/j.1526-4637.2012.01511.x · Cited by 16
Neuron–microglia interactions modulating neuropathic pain
Kohno, K., & Tsuda, M. (2025) · International Immunology · doi:10.1093/intimm/dxaf022 · Cited by 18
Spinal microglial P2X4 receptor–brain-derived neurotrophic factor signaling regulates nicotine withdrawal-induced hyperalgesia
Zhang, X., Pengcheng, X., Li, C., Zhu, W., Wu, S., Yu, A., Ding, Y., Wang, Q., & Zhang, Z. (2017) · Neuroreport · doi:10.1097/wnr.0000000000000769 · Cited by 16
STAU1 selectively regulates the expression of inflammatory and immune response genes and alternative splicing of the nerve growth factor receptor signaling pathway
田中, 義., Hu, Z., Wu, J., Dai, F., Lee, F., & Xu, Y. (2020) · Oncology Reports · doi:10.3892/or.2020.7769 · Cited by 16
Serum CX3CL1/fractalkine concentrations are positively associated with disease severity in postmenopausal osteoporotic patients
Chen, Y., Huang, C., Liu, H.-Y., Yao, W., Wu, W., Lu, Y., & Wang, W. (2016) · British Journal of Biomedical Science · doi:10.1080/09674845.2016.1209897 · Cited by 16
Cathepsin S as a potential therapeutic target for chronic pain
Montague-Cardoso, K., & Malcangio, M. (2020) · Medicine in Drug Discovery · doi:10.1016/j.medidd.2020.100047 · Cited by 15
Use of laser microdissection in the investigation of facial motoneuron and neuropil molecular phenotypes after peripheral axotomy
Mesnard, N. A., Alexander, T. D., Sanders, V. M., et al. (2010) · Experimental Neurology · doi:10.1016/j.expneurol.2010.05.019 · Cited by 14
Evidence that LPS-reactive arthritis in rats depends on the glial activity and the fractalkine–TNF-α signaling in the spinal cord
Bressan, E., Peres, K. C., & Tonussi, C. R. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.09.028 · Cited by 14
Differential Gene Expression in the Axotomized Facial Motor Nucleus of Presymptomatic SOD1 Mice
Mesnard, N., Sanders, V. M., & Jones, K. (2011) · The Journal of comparative neurology · doi:10.1002/cne.22718 · Cited by 14
A state-of-the-art perspective on microgliopathic pain
Inoue, K. (2018) · Open Biology · doi:10.1098/rsob.180154 · Cited by 16
Long noncoding RNA LOC100911498 is a novel regulator of neuropathic pain in rats
Tang, W., Zhang, L., & Li, Z. (2021) · Brain and Behavior · doi:10.1002/brb3.1966 · Cited by 14
Spinal glia-driven neuroinflammation as a therapeutic target for neuropathic pain: Rational development of novel analgesics
Zhang, Z., Niu, Z., & Dong, S. (2025) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2025.106404 · Cited by 18
Reorganization of synaptic inputs to spinal dorsal horn neurons in neuropathic pain
Terayama, R., & Uchibe, K. (2021) · International Journal of Neuroscience · doi:10.1080/00207454.2021.1873980 · Cited by 13
Ex-vivo expression of chemokine receptors on cells surrounding cutaneous nerves in patients with HIV-associated sensory neuropathy
Mountford, J., Octaviana, F., Estiasari, R., et al. (2017) · AIDS · doi:10.1097/qad.0000000000001714 · Cited by 13
Upregulation of Inflammatory Mediators in Peripheral Blood CD40+ Cells in Children with Autism Spectrum Disorder
Aldossari, A. A., Ansari, M. A., Nadeem, A., Attia, S. M., Bakheet, S. A., AL-Ayadhi, L. Y., Alanazi, M. M., Shahid, M., Alwetaid, M. Y., Hussein, M. H., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087475 · Cited by 13
Elevated Fractalkine (CX3CL1) Levels in the Trigeminal Ganglion Mechanically Sensitize Temporalis Muscle Nociceptors
Cairns, B. E., O’Brien, M. S., Dong, X., et al. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-9935-x · Cited by 13
Gene therapy for chronic neuropathic pain: how does it work and where do we stand today?
Kumar, S., Ruchi, R., James, S. R., & Chidiac, E. (2011) · Pain medicine (Malden, Mass.) · doi:10.1111/j.1526-4637.2011.01120.x · Cited by 14
Macrophage: A key player in neuropathic pain
Ye, Y., Cheng, H., Wang, Y., Sun, Y., Zhang, L., & Tang, J. (2024) · International Reviews of Immunology · doi:10.1080/08830185.2024.2344170 · Cited by 13
Gene-based approaches in pain research and exploration of new therapeutic targets and strategies.
Molet, J., & Pohl, M. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.01.073 · Cited by 15
Notch1 Signaling Contributes to Mechanical Allodynia Associated with Cyclophosphamide‐Induced Cystitis by Promoting Microglia Activation and Neuroinflammation
Chen, J., Ding, H., Liu, B., Zhou, X., Zhou, X. J., Lin, Z., Yang, F., Zhan, H., & Xiao, H. (2021) · Mediators of Inflammation · doi:10.1155/2021/1791222 · Cited by 12
Burst-Like Subcutaneous Electrical Stimulation Induces BDNF-Mediated, Cyclotraxin B-Sensitive Central Sensitization in Rat Spinal Cord
Retamal, J. S., Reyes, A., Ramírez-García, P. D., Bravo, D., Hernández, A., Pélissier, T., Villanueva, L., & Constandil, L. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01143 · Cited by 12
Cytochrome P450 26A1 Contributes to the Maintenance of Neuropathic Pain
Cao, D., Ma, L.-J., Jiang, B., Gu, Q., & Gao, Y. (2023) · Neuroscience Bulletin · doi:10.1007/s12264-023-01101-1 · Cited by 12
The Role of Fractalkine in Diabetic Retinopathy: Pathophysiology and Clinical Implications
Lee, C.-Y., & Yang, C. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26010378 · Cited by 11
Targeting Chemokines and Chemokine GPCRs to Enhance Strong Opioid Efficacy in Neuropathic Pain
Vincenzi, M., Milella, M. S., D’Ottavio, G., Caprioli, D., Reverte, I., & Maftei, D. (2022) · Life · doi:10.3390/life12030398 · Cited by 11
Cerebrospinal fluid-contacting nucleus mediates nociception via release of fractalkine
Zhou, Q. Q., Chen, S. S., Zhang, Q. Q., Liu, P. F., Fang, H. Z., Yang, Y., & Zhang, L. C. (2017) · Brazilian Journal of Medical and Biological Research · doi:10.1590/1414-431x20176275 · Cited by 11
Up-Regulation of CX3CL1 via STAT3 Contributes to SMIR-Induced Chronic Postsurgical Pain
Shen, Y., Li, D., Li, B., Peng, X., Zhang, Y., Jiang, Y.-S., Xu, Y., Chen, H., & Xiong, Y.-C. (2018) · Neurochemical Research · doi:10.1007/s11064-017-2449-8 · Cited by 12
Role of Endocannabinoids in Neuron-Glial Crosstalk
Luongo, L., Palazzo, E., de Novellis, V., & Maione, S. (2010) · The Open Pain Journal · doi:10.2174/1876386301003010029 · Cited by 11
Electroacupuncture Treatment Suppresses Transcription Factor IRF8 in Spinal Cord of Rats with Spared Nerve Injury
Wang, Y., Xue, M., Xia, Y.-Y., Jiang, Q., Huang, Z.-H., & Huang, C. (2020) · Pain Research and Management · doi:10.1155/2020/1854363 · Cited by 10
Activation of translocator protein alleviates mechanical allodynia and bladder dysfunction in cyclophosphamide‐induced cystitis through repression of BDNF‐mediated neuroinflammation
Huang, Y. L., Su, M., Zhang, C., Zhan, H., Yang, F., Gao, Z., Zhou, X., & Liu, B. (2022) · European Journal of Pain · doi:10.1002/ejp.1942 · Cited by 10
Spinal CX3CL1/CX3CR1 May Not Directly Participate in the Development of Morphine Tolerance in Rats
Peng, Y.-W., Guo, G., Shu, B., Liu, D.-Q., Su, P., Zhang, X., & Gao, F. (2017) · Neurochemical Research · doi:10.1007/s11064-017-2364-z · Cited by 9
Gene Expression Profiling of Cx3cl1 in Bone Marrow Mesenchymal Stem Cells by Osteogenic Induction
Xiao, J., Dong, H. Y., Wu, Y., et al. (2009) · OMICS A Journal of Integrative Biology · doi:10.1089/omi.2009.0018 · Cited by 10
Glial Mechanisms of Neuropathic Pain and Emerging Interventions
Jo, D. H., Chapman, C. R., & Light, A. R. (2009) · The Korean journal of pain · doi:10.3344/kjp.2009.22.1.1 · Cited by 10
The effect and mechanism of low-dose esketamine in neuropathic pain-related depression-like behavior in rats
Wang, L., Zhao, S., Shao, J., & Su, C. (2024) · Brain Research · doi:10.1016/j.brainres.2024.149117 · Cited by 11
Chemokine CCL2 Mediates Neuroglial Crosstalk and Drives Chronic Pain Pathogenesis
Lu, J., Shi, Y., Li, Y., Niu, Z., Wu, S., Luo, C., & Xie, R. (2025) · Neuroscience Bulletin · doi:10.1007/s12264-025-01519-9 · Cited by 10
Microglia and p38 MAPK Inhibitors Suppress Development of Mechanical Allodynia in Both Sexes in a Mouse Model of Antiretroviral-Induced Neuropathic Pain
Al-HadlaQ, M. W., & Masocha, W. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241612805 · Cited by 9
Molecular Changes Involving MEK3–p38 MAPK Activation in Chronic Masticatory Myalgia
Meng, H., Gao, Y., Kang, Y. F., Zhao, Y., Yang, G. J., Wang, Y., Cao, Y., Gan, Y.-H., & Xie, Q. F. (2016) · Journal of Dental Research · doi:10.1177/0022034516659441 · Cited by 9
AMPKα1 knockout enhances nociceptive behaviors and spinal glutamatergic synaptic activities via production of reactive oxygen species in the spinal dorsal horn
Maixner, D. W., Yan, X., Hooks, S. B., & Weng, H. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.03.061 · Cited by 9
Upregulation in Rat Spinal Cord Microglia of the Nonintegrin Laminin Receptor 37 kDa-LRP following Activation by a Traumatic Lesion or Peripheral Injury
Baloui, H., Stettler, O., Weiss, S. F. T., Nothias, F., & von Boxberg, Y. (2009) · Journal of Neurotrauma · doi:10.1089/neu.2008.0677 · Cited by 9
Inflammatory Mediators, Nociceptors, and Their Interactions in Pain
Ji, J., Huh, Y., & Ji, R. (2023) · Springer eBooks · doi:10.1007/978-3-031-29231-6_4 · Cited by 8
Self-citation
Upregulation of TLR9 may contribute to activation of microglia and painful diabetic neuropathy via the p38 MAPK pathway in rats.
Niu, Z., Bao, L., & Chen, J. (2022) · PubMed · doi:10.14670/hh-18-405 · Cited by 8
Global analyses of mRNA expression in human sensory neurons reveal eIF5A as a conserved target for inflammatory pain
Chase, R., de la Peña, J. B., Smith, P. R., Lawson, J. M., Lou, T., Stanowick, A. D., Black, B. J., & Campbell, Z. T. (2022) · The FASEB Journal · doi:10.1096/fj.202101933rr · Cited by 8
Reversal of neurochemical alterations in the spinal dorsal horn and dorsal root ganglia by Mas-related gene (Mrg) receptors in a rat model of spinal nerve injury
Wang, D., Xue, Y., Yan, Y., et al. (2016) · Neurobiology of Disease · doi:10.1016/j.nbd.2016.03.020 · Cited by 8
Self-citation
Bujing Yishi tablets alleviate photoreceptor cells death via the P2X7R/CX3CL1/CX3CR1 pathway in Retinitis Pigmentosa rats
Qi, Y., Liu, L., Liang, D., Tang, S., Yu, X., Ye, H., & Chen, N. (2023) · Phytomedicine · doi:10.1016/j.phymed.2023.154828 · Cited by 7
Bibliometric and visual analysis of microglia-related neuropathic pain from 2000 to 2021
Zhang, S.-B., Zhao, G., Lv, T.-R., Gong, C.-Y., Shi, Y., Nan, W., & Zhang, H. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1142852 · Cited by 7
Microglia Are Involved in Regulating Histamine Dependent and Non-Dependent Itch Transmissions With Distinguished Signal Pathways
Yang, Y., Mou, B., Zhang, Q., Zhao, H., Zhang, J., Yun, X. Y., Xiong, M., Liu, Y., Liu, Y., Pan, H., et al. (2022) · Glia · doi:10.1002/glia.24438 · Cited by 7
Spinal p38 activity and analgesic effect after low- and high-intensity electroacupuncture stimulation in a plantar incision rat model
Hsu, S.-F., Zeng, Y.-J., Tsai, S.-Y., et al. (2015) · Life Sciences · doi:10.1016/j.lfs.2015.01.035 · Cited by 7
Self-citation
Study protocol for a phase II, double-blind, randomised controlled trial of cannabidiol (CBD) compared with placebo for reduction of brain neuroinflammation in adults with chronic low back pain
Pike, C., Kim, M., Schnitzer, K., Mercaldo, N. D., Edwards, R. R., Napadow, V., Zhang, Y., Morrissey, E. J., Alshelh, Z., Evins, A. E., et al. (2022) · BMJ Open · doi:10.1136/bmjopen-2022-063613 · Cited by 7
Hyperexcitability in Spinal WDR Neurons following Experimental Disc Herniation Is Associated with Upregulation of Fractalkine and Its Receptor in Nucleus Pulposus and the Dorsal Root Ganglion
Jacobsen, D. P., Moen, A., Haugen, F., et al. (2016) · International Journal of Inflammation · doi:10.1155/2016/6519408 · Cited by 7
X-ray Irradiation Improves Neurological Function Recovery of Injured Spinal Cord by Inhibiting Inflammation and Glial Scar Formation
Wang, Y., Niu, Y., Lin, F., Su, P., Chen, L., Liu, D., & Sun, Y. A. (2022) · Journal of Molecular Neuroscience · doi:10.1007/s12031-022-01975-2 · Cited by 6
CXCR3 signalling partially contributes to the pathogenesis of neuropathic pain in male rodents
Li, K., Tan, Y., Feng, S., & Fu, K. (2021) · Journal of Oral Rehabilitation · doi:10.1111/joor.13262 · Cited by 6
Chronic Pain: Epidemiology, Pathophysiology, and Clinical Management
Shang, Z., Tian, Z., Wang, Z., Yang, Z., Wang, Z., Wang, Z., Wang, Z., He, X., Yu, Y., Gong, Y., et al. (2026) · MedComm · doi:10.1002/mco2.70756 · Cited by 5
Exercise intervention alleviates nerve injury by the suppression of inflammatory mediator expression via the TLR4/NF‑κB signaling pathway
Sun, Y., Liu, J., & Tian, F. (2018) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2018.6581 · Cited by 5
The Role of Spinal Cord CX3CL1/CX3CR1 Signalling in Chronic Pain
Montague-Cardoso, K., Mrózková, P., & Malcangio, M. (2020) · Current Tissue Microenvironment Reports · doi:10.1007/s43152-020-00006-9 · Cited by 5
Decoding chronic pain: insights into the transition from acute to persistent pain
Wadhwa, K., Chauhan, P., Singh, G., Jha, S. K., Almutary, A. G., & Jha, N. K. (2025) · Open Biology · doi:10.1098/rsob.240234 · Cited by 5
Glial cells in neuropathic pain
Berta, T., Khoutorsky, A., Xu, J., & Ji, R. (2026) · Physiological Reviews · doi:10.1152/physrev.00034.2025 · Cited by 7
Self-citation
The Ambivalent Role of Glial Cells in Neuroinflammation and Neuropathic Pain
Shanti, B. F., Shanti, I. F., Al-Abbadi, K., Rjoub, A. A., & Otom, A. H. (2020) · Acta Scientific Neurology · doi:10.31080/asne.2020.03.0195 · Cited by 3
Mecanismos del dolor neuropático: Del laboratorio a la clínica
Gómez-Barrios, J. V., & Tortorici, V. (2009) · Redalyc (Universidad Autónoma del Estado de México) · Cited by 3
The novel therapeuthic targets in the treatment of chronic pain.
Palomba, R., Bonaccia, P., Graffi, M., & Costa, F. (2012) · Europe PMC (PubMed Central) · Cited by 3
Retracted
Prior perineural or neonatal treatment with capsaicin does not alter the development of spinal microgliosis induced by peripheral nerve injury
Szeredi, I. D., Jancsó, G., Oszlács, O., et al. (2020) · Cell and Tissue Research · doi:10.1007/s00441-020-03285-8 · Cited by 3
Zytokinregulation und Schmerz
Üçeyler, N., & Sommer, C. (2008) · Der Schmerz · doi:10.1007/s00482-008-0706-0 · Cited by 3
De nouvelles perspectives pour les chimiokines
Rostène, W. H. (2010) · Biologie Aujourd hui · doi:10.1051/jbio/2010020 · Cited by 3
A Novel Mechanism of BAM8-22 Inhibiting Microglia Activation: Represses CX3CR1 Expression via Upregulating miR-184
Wang, A., Tie, M., Guo, D., et al. (2019) · Journal of Molecular Neuroscience · doi:10.1007/s12031-019-01455-0 · Cited by 3
Spinal plasticity of the nociceptive system
Latrémolière, A. (2016) · Wiley eBooks · doi:10.1002/9781118455968.ch2 · Cited by 4
Neuro-immune contributors to persistent musculoskeletal pain: from mechanisms to clinical assessment and management
Ridehalgh, C., Fundaun, J., & Farrell, S. F. (2025) · Musculoskeletal Science and Practice · doi:10.1016/j.msksp.2025.103468 · Cited by 2
Cognitive and transcriptomic effects of Epigallocatechin gallate in fetal alcohol spectrum disorders
Ramos-Triguero, A., Astals, M., Navarro‐Tapia, E., Vieiros, M., Bastons-Compta, A., Martínez, L., Andreu-Férnández, V., & García‐Algar, Ó. (2026) · Scientific Reports · doi:10.1038/s41598-025-34576-1 · Cited by 2

Authors: Zhuang, Z.-Y., Kawasaki, Y., Tan, P.-H., Wen, Y.-R., Huang, J., & Ji, R.-R.
Affiliations: Brigham and Women's Hospital (US)
Corresponding author: Ji, Ru-Rong
ORCID: Tan, Ping-Heng
Wen, Yeong-Ray
Huang, Jing
Ji, Ru-Rong
Venue: Brain, Behavior, and Immunity
Publisher: Elsevier BV
Published: 2007-07
Volume: 21
Issue: 5
Pages: 642-651
ISSN: 0889-1591 (ISSN-L)
DOI: 10.1016/j.bbi.2006.11.003
PMC: PMC2084372
OpenAlex: W2006680088
Semantic Scholar: 64f3a09c34ad12759b6e063e279570703bf27e54
Cited by: 371
References: 51
Citations by year: 2026: 14 · 2025: 7 · 2024: 5 · 2023: 19 · 2022: 17 · 2021: 19 · 2020: 26 · 2019: 15 · 2018: 26 · 2017: 17 · 2016: 24 · 2015: 16 · 2014: 25 · 2013: 23 · 2012: 17
FWCI: 12.15
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Brain Behavior and Immunity (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
Fogarty International Center (R03TW007180)
National Institute of Neurological Disorders and Stroke (R01NS040698)
National Institute of Dental and Craniofacial Research (R01DE017794, R01 DE17794)
Topics: Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
Keywords: neuropathic pain, spinal microglia, CX3CR1, fractalkine, p38 MAPK, spinal nerve ligation, mechanical allodynia, dorsal root ganglia, microglial activation, excitatory synaptic transmission
MeSH terms: CX3C Chemokine Receptor 1, Analysis of Variance, Animals, Disease Models, Animal, Ligation, Male, Membrane Proteins, Neuralgia, Spinal Cord, Spinal Nerves, Signal Transduction, Rats, Sprague-Dawley, Pain Threshold, Microglia, Statistics, Nonparametric, Receptors, Chemokine, Chemokines, CX3C, Posterior Horn Cells, p38 Mitogen-Activated Protein Kinases, Rats, Chemokine CX3CL1

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Role of the CX3CR1/p38 MAPK pathway in spinal microglia for the development of neuropathic pain following nerve injury-induced cleavage of fractalkine

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks