Stress and inflammation in exacerbations of asthma
Open accessAbstract
In this mini-review, we outline a model depicting the immunologic mechanisms by which psychological stress can exacerbate clinical symptoms in patients with asthma. This model highlights the importance of both social and physical exposures in the exacerbation of asthma symptoms. The basic premise of the model is that psychological stress operates by altering the magnitude of the airway inflammatory response that irritants, allergens, and infections bring about in persons with asthma. The biological pathways for how stress amplifies the immune response to asthma triggers include the hypothalamic-pituitary-adrenal (HPA) axis, the sympathetic-adrenal-medullary (SAM) axis, and the sympathetic (SNS) and parasympathetic (PNS) arms of the autonomic nervous system. Empirical evidence for this model is reviewed, and conclusions and future research directions are discussed.
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Evidence of altered glucocorticoid sensitivity has been found in several other disorders including anxiety, posttraumatic stress disorder, asthma, rheumatoid arthritis, cardiovascular disease, inflammatory bowel disease, autoimmune diseases, and some cancers.
“Evidence of altered glucocorticoid sensitivity has also been found in several other disorders including anxiety, posttraumatic stress disorder, asthma, rheumatoid arthritis, cardiovascular disease, inflammatory bowel disease, autoimmune diseases, and some cancers”
From From stress to inflammation and major depressive disorder: A social signal transduction theory of depression. (2014) · cites this paper as Chen & Miller, 2007
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References 37 · Cited by 394
- Authors
- Chen, E., & Miller, G. E.
- Affiliations
- University of British Columbia (CA)
- Corresponding author
- Chen, Edith
- Venue
- Brain, Behavior, and Immunity
- Publisher
- Elsevier BV
- Published
- 2007-11
- Volume
- 21
- Issue
- 8
- Pages
- 993-999
- ISSN
- 0889-1591 (ISSN-L)
- PMC
- PMC2077080
- OpenAlex
- W2132405776
- Cited by
- 394
- References
- 37
- Citations by year
- 2026: 18 · 2025: 22 · 2024: 22 · 2023: 23 · 2022: 22 · 2021: 23 · 2020: 25 · 2019: 21 · 2018: 29 · 2017: 17 · 2016: 24 · 2015: 24 · 2014: 20 · 2013: 16 · 2012: 28
- FWCI
- 1.60
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Brain Behavior and Immunity (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute (HL073975, R01HL073975)
- Topics
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Keywords
- asthma exacerbations, psychological stress, airway inflammation, hypothalamic-pituitary-adrenal axis, sympathoadrenal system, autonomic nervous system, stress-immune interaction, allergens, airway irritants, respiratory infections, social stressors
- MeSH terms
- Allergens, Asthma, Humans, Hypothalamo-Hypophyseal System, Life Change Events, Models, Biological, Pituitary-Adrenal System, Stress, Psychological, Sympathetic Nervous System, Neuroimmunomodulation
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