Psychobiological responses to social threat: Evolution of a psychological model in psychoneuroimmunology
Abstract
There exists a bidirectional network of interactions between the central nervous system, the endocrine system and the immune system. The existence of these pathways allows stressful life experience to impact the immune system with important implications for health. One powerful elicitor of changes in the autonomic, endocrine and immune systems is threat to social status. This review describes the development of a human model of social status threat that specifies a set of contextual, psychological and biological pathways that may underlie the health consequences of threats to social status and regard. The role of cognitive processes in shaping the physiological response to the social world will be emphasized.
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Stressors that evoke the strongest inflammatory responses in the laboratory are those that involve social conflict, rejection, or exclusion.
“stressors that evoke the strongest inflammatory responses in the laboratory are those that involve social conflict, rejection, or exclusion”
From From stress to inflammation and major depressive disorder: A social signal transduction theory of depression. (2014) · cites this paper as Kemeny, 2009
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References 96 · Cited by 138
- Authors
- Kemeny, M. E.
- Affiliations
- University of California, San Francisco (US)
- Corresponding author
- Kemeny, Margaret E.
- Venue
- Brain, Behavior, and Immunity
- Publisher
- Elsevier BV
- Published
- 2009-01
- Volume
- 23
- Issue
- 1
- Pages
- 1-9
- ISSN
- 0889-1591 (ISSN-L)
- OpenAlex
- W2040247384
- Cited by
- 138
- References
- 96
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 4 · 2023: 8 · 2022: 3 · 2021: 7 · 2020: 11 · 2019: 8 · 2018: 8 · 2017: 9 · 2016: 11 · 2015: 5 · 2014: 6 · 2013: 6 · 2012: 13
- FWCI
- 0.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Behavior and Immunity (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Evolutionary Psychology and Human Behavior
- Keywords
- social danger, psychoneuroimmunology, autonomic nervous system, endocrine-immune interaction, cognitive appraisal, psychological model, stress effects
- MeSH terms
- Adaptation, Psychological, Humans, Models, Psychological, Psychoneuroimmunology, Social Environment, Stress, Psychological, Neuroimmunomodulation
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