The direction of synaptic plasticity mediated by C-fibers in spinal dorsal horn is decided by Src-family kinases in microglia: The role of tumor necrosis factor-α

Zhong, Yi; Zhou, Li-Jun; Ren, Wen-Jie; Xin, Wen-Jun; Li, Yong-Yong; Zhang, Tong; Liu, Xian-Guo

doi:10.1016/j.bbi.2010.01.007

The direction of synaptic plasticity mediated by C-fibers in spinal dorsal horn is decided by Src-family kinases in microglia: The role of tumor necrosis factor-α

Previous studies have shown that Src-family kinases (SFKs) are selectively activated in spinal microglia following peripheral nerve injury and the activated SFKs play a key role for the development of neuropathic pain. To investigate the underlying mechanism, in the present study the effect of SF…