The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Neural aspects of immunomodulation: Focus on the vagus nerve
Open accessAbstract
Inflammation and immunity have been implicated in a wide variety of diseases and disorders ranging from Alzheimer’s disease to cardiovascular disease to hemorrhagic shock. In this review, we will briefly consider the evidence for the neural concomitants of immunomodulation. First, we will briefly review the anatomy and physiology of neural-immune communication. Evidence for the somatotopic organization of the vagus nerve and for pain processes suggests that such an organization may be relevant for the investigation of the neural concomitants of immunity. Then we will provide an overview of what is known from both animal and human studies including neuroimaging and clinical studies. Finally, we will discuss some of the challenges and opportunities in this exciting area of investigation.
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Citations
Cites
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Self-citationThayer, J. F., & Lane, R. D. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.08.004 · Cited by 2,040
Self-citationPhysiology and immunology of the cholinergic antiinflammatory pathway
Tracey, K. J. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30555 · Cited by 1,563 · cited 4×
“Challenges and opportunities Tracey (2007) has suggested that future research on the connections between the brain and the immune system may reveal an immunological homunculus.”
BackgroundInfluentialFunctional and chemical anatomy of the afferent vagal system
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Human cingulate cortex and autonomic control: converging neuroimaging and clinical evidence
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“N IH -PA Author M anuscript N IH -PA Author M anuscript N IH -PA Author M anuscript alpha 7 nicotinic receptors that inhibit NF kappa B and thus cytokine synthesis and release (Rosas-Ballina and Tracey, 2009).”
BackgroundAutonomic innervation and regulation of the immune system (1987–2007)
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Self-citation
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Danese, A., & McEwen, B. S. (2012) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.08.019 · Cited by 2,140
Hannestad, J., DellaGioia, N., & Bloch, M. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.132 · Cited by 914
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Deutschman, C. S., & Tracey, K. J. (2014) · Immunity · doi:10.1016/j.immuni.2014.04.001 · Cited by 677
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Bevans, M., & Sternberg, E. M. (2012) · JAMA · doi:10.1001/jama.2012.29 · Cited by 620
Self-citationSlavich, G. M. (2020) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-032816-045159 · Cited by 502
“It outputs to several organs including the heart, liver, gastrointestinal tract, intestine, and (possibly) the spleen, where it downregulates the production of the inflammatory cytokines IL-1β, IL-18, and TNF-α via alpha7 nicotinic receptors that inhibit NF-κB activity (Thayer & Sternberg 2010).”
Background
Metadata
- Authors
- Thayer, J. F., & Sternberg, E. M.
- Venue
- Brain, Behavior, and Immunity
- Publisher
- Elsevier BV
- Published
- 2010-11
- Volume
- 24
- Issue
- 8
- Pages
- 1223-1228
- ISSN
- 0889-1591 (ISSN-L)
- OpenAlex
- W2064271564
- Cited by
- 200
- References
- 15
- FWCI
- 5.38
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
