Sleep disturbance, inflammation and depression risk in cancer survivors
Open accessAbstract
Over two-thirds of the 11.4 million cancer survivors in the United States can expect long-term survival, with many others living with cancer as a chronic disease controlled by ongoing therapy. However, behavioral co-morbidities often arise during treatment and persist long-term to complicate survival and reduce quality of life. In this review, the inter-relationships between cancer, depression, and sleep disturbance are described, with a focus on the role of sleep disturbance as a risk factor for depression. Increasing evidence also links alterations in inflammatory biology dynamics to these long-term effects of cancer diagnosis and treatment, and the hypothesis that sleep disturbance drives inflammation, which together contribute to depression, is discussed. Better understanding of the associations between inflammation and behavioral co-morbidities has the potential to refine prediction of risk and development of strategies for the prevention and treatment of sleep disturbance and depression in cancer survivors.
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Symptoms such as fatigue, depression, anxiety, and insomnia commonly co-occur across the cancer treatment and survivorship trajectory and may have shared roots such as inflammation.
“Commonly co-occurring across the cancer treatment and survivorship trajectory (118), symptoms such as fatigue, depression, anxiety, and insomnia may have shared roots, such as inflammation (18).”
From Interventions for insomnia in cancer patients and survivors-a comprehensive systematic review and meta-analysis (2024) · cites this paper as [18]
The Introduction and “Inflammation, Sleep Disturbance and Depressive Symptoms in Cancer” Overview link inflammation to depression, sleep disturbance, and fatigue during treatment and survivorship. The paper does not similarly identify inflammation as a shared root of anxiety. The co-occurrence clause carries a different citation (118), so this verdict concerns the shared-roots claim attached to this source (18). (LLM, conf=0.84)
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References 126 · Cited by 173
- Authors
- Irwin, M. R., Olmstead, R. E., Ganz, P. A., & Haque, R.
- Affiliations
- University of California, Los Angeles (US)
- Kaiser Permanente (US)
- Venue
- Brain Behavior and Immunity
- Publisher
- Elsevier BV
- Published
- 2013-03
- Volume
- 30
- Pages
- S58-S67
- ISSN
- 0889-1591 (ISSN-L)
- PMC
- PMC3435451
- OpenAlex
- W2161967272
- Cited by
- 173
- References
- 126
- Citations by year
- 2026: 15 · 2025: 10 · 2024: 9 · 2023: 12 · 2022: 16 · 2021: 19 · 2020: 17 · 2019: 14 · 2018: 7 · 2017: 12 · 2016: 12 · 2015: 13 · 2014: 10 · 2013: 6 · 2012: 1
- FWCI
- 0.99
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Brain Behavior and Immunity (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Cousins Center for Psychoneuroimmunology (R01-CA 109650)
- Breast Cancer Research Foundation (R01CA136743-01A2)
- Topics
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- sleep disorders, inflammation, depression, cancer survivors, behavioral comorbidities, chronic cancer, risk factors, quality of life, depression prevention
- MeSH terms
- Depression, Depressive Disorder, Humans, Inflammation, Neoplasms, Quality of Life, Risk, Sleep Wake Disorders, Survivors
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