Gasdermin D activation in oligodendrocytes and microglia drives inflammatory demyelination in progressive multiple sclerosis

Pollock, Niall M.; Fernandes, Jason P.; Woodfield, Jenilee; Moussa, Eman; Hlavay, Brittyne; Branton, William G.; Wuest, Melinda; Mohammadzadeh, Nazanin; Schmitt, Laura; Plemel, Jason R.; Julien, Olivier; Wuest, Frank; Power, Christopher

doi:10.1016/j.bbi.2023.10.022

Gasdermin D activation in oligodendrocytes and microglia drives inflammatory demyelination in progressive multiple sclerosis

Neuroinflammation coupled with demyelination and neuro-axonal damage in the central nervous system (CNS) contribute to disease advancement in progressive multiple sclerosis (P-MS). Inflammasome activation accompanied by proteolytic cleavage of gasdermin D (GSDMD) results in cellular hyperactivati…