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Neurological abnormalities in caveolin-1 knock out mice

Trushina, Eugenia, Du Charme, Jordan, Parisi, Joseph, McMurray, Cynthia T.·2006·Behavioural Brain Research
DOI 10.1016/j.bbr.2006.04.024
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Abstract

Caveolin-1 is the defining structural protein in caveolar vesicles, which regulate signal transduction and cholesterol trafficking in cells. In the brain, cav-1 is highly expressed in neurons and glia, but its function in those cell types is unclear. Mice deficient in cav-1 (CavKO) have been developed to test functional roles for cav-1 in various tissues. However, neurological phenotypes associated with loss of cav-1 in mice have not been evaluated. Here, we report the results of motor and behavioral testing of CavKO mice. We find that mice deficient in cav-1 have reduced brain weight and display a number of motor and behavioral abnormalities. CavKO mice develop neurological phenotypes including clasping, abnormal spinning, muscle weakness, reduced activity, and gait abnormalities. These data suggest that cav-1 is involved in maintaining cortico-striato-pallido-thalamo-pontine pathways associated with motor control.

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Crossref · 10.1016/j.bbr.2006.04.024

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  • Mice deficient in Cav1 have neurologic motor phenotypes including clasping, abnormal spinning, muscle weakness, and gait abnormalities.

    “Furthermore, mice deficient in Cav1 have neurologic motor phenotypes including clasping, abnormal spinning, muscle weakness, and gait abnormalities (47), confirming the importance of CAV1 in motor function.”

    From Hereditary spastic paraplegia SPG8 mutations impair CAV1-dependent, integrin-mediated cell adhesion (2020) · cites this paper as [47]

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Research works printed but not linked: 29

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Metadata

Authors
Trushina, E., Du Charme, J., Parisi, J., & McMurray, C. T.
Venue
Behavioural Brain Research
Publisher
Elsevier BV
Published
2006-09
Volume
172
Issue
1
Pages
24-32
ISSN
0166-4328
DOI
10.1016/j.bbr.2006.04.024
Cited by
76
References
0
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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