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Time-course gait analysis of hemiparkinsonian rats following 6-hydroxydopamine lesion

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Hsieh, Tsung-Hsun, Chen, Jia-Jin J., Chen, Li-Hsien, Chiang, Pei-Tzu, Lee, Hsiao-Yu·2011·Behavioural Brain Research
DOI 10.1016/j.bbr.2011.03.031
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Abstract

Gait disturbances similar to those of human Parkinson's disease (PD) can be observed in animals after administration of neurotoxin 6-hydroxydopamine (6-OHDA) to induce unilateral nigrostriatal dopamine depletion. However, the relationship between gait disturbances and dopamine depletion following 6-OHDA infusion has not been determined. The present study investigated the longitudinal changes of spatiotemporal gait patterns using a walkway system to acquire footprints and lateral limb images over a 6-week period following unilateral 6-OHDA injection into the medial forebrain bundle of rats. Our results indicated that hemiparkinsonian rats exhibited changes in gait patterns, as compared to normal controls, and pre-lesion levels, including a significantly decreased walking speed and step/stride length as well as an increased base of support and foot angle. The relative percentage of the gait cycle was also altered, showing an increase in the stance to swing ratio, which was more evident in the affected hindlimb. Time-course observations showed that these gait disturbances occurred as early as 4 days post-lesion and gradually increased up to 42 days post-injury. The extents of gait disturbances were compared with conventional apomorphine-induced turning behavior and akinesia bar tests, which were also apparent at 4 days post-lesion but remained relatively unchanged after 28 days. Our time-course gait analysis of a unilateral 6-OHDA rodent model provides insight into the compensatory changes of motor functions during the 6-week development of a nigrostriatal lesion, which might be useful for future objective assessment of novel treatments for human PD subjects.

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Research works printed but not linked: 44

  1. Bjorklund, 2007, Dopamine neuron systems in the brain: an update, Trends Neurosci, 30, 194, 10.1016/j.tins.2007.03.006 · DOI · Paper page
  2. Giladi, 2001, Freezing of gait in patients with advanced Parkinson's disease, J Neural Transm, 108, 53, 10.1007/s007020170096 · DOI · Paper page
  3. Chee, 2009, Gait freezing in Parkinson's disease and the stride length sequence effect interaction, Brain, 132, 2151, 10.1093/brain/awp053 · DOI · Paper page
  4. Blin, 1990, Quantitative analysis of gait in Parkinson patients: increased variability of stride length, J Neurol Sci, 98, 91, 10.1016/0022-510X(90)90184-O · DOI · Paper page
  5. Truong, 2006, Developing a preclinical model of Parkinson's disease: a study of behaviour in rats with graded 6-OHDA lesions, Behav Brain Res, 169, 1, 10.1016/j.bbr.2005.11.026 · DOI
  6. Deumens, 2002, Modeling Parkinson's disease in rats: an evaluation of 6-OHDA lesions of the nigrostriatal pathway, Exp Neurol, 175, 303, 10.1006/exnr.2002.7891 · DOI · Paper page
  7. Mabrouk, 2009, The novel delta opioid receptor agonist UFP-512 dually modulates motor activity in hemiparkinsonian rats via control of the nigro-thalamic pathway, Neuroscience, 164, 360, 10.1016/j.neuroscience.2009.08.058 · DOI
  8. Fantin, 2008, Differential effect of NR2A and NR2B subunit selective NMDA receptor antagonists on striato-pallidal neurons: relationship to motor response in the 6-hydroxydopamine model of parkinsonism, J Neurochem, 106, 957, 10.1111/j.1471-4159.2008.05439.x · DOI
  9. Lindner, 1997, Rats with partial striatal dopamine depletions exhibit robust and long-lasting behavioral deficits in a simple fixed-ratio bar-pressing task, Behav Brain Res, 86, 25, 10.1016/S0166-4328(96)02240-1 · DOI
  10. Lindner, 1996, Validation of a rodent model of Parkinson's disease: evidence of a therapeutic window for oral Sinemet, Brain Res Bull, 39, 367, 10.1016/0361-9230(96)00027-5 · DOI
  11. Metz, 2005, The unilateral 6-OHDA rat model of Parkinson's disease revisited: an electromyographic and behavioural analysis, Eur J Neurosci, 22, 735, 10.1111/j.1460-9568.2005.04238.x · DOI
  12. Amende, 2005, Gait dynamics in mouse models of Parkinson's disease and Huntington's disease, J Neuroeng Rehabil, 2, 20, 10.1186/1743-0003-2-20 · DOI
  13. Chang, 2006, Neural responses in multiple basal ganglia regions following unilateral dopamine depletion in behaving rats performing a treadmill locomotion task, Exp Brain Res, 172, 193, 10.1007/s00221-005-0312-7 · DOI
  14. Klein, 2009, Walking pattern analysis after unilateral 6-OHDA lesion and transplantation of foetal dopaminergic progenitor cells in rats, Behav Brain Res, 199, 317, 10.1016/j.bbr.2008.12.007 · DOI
  15. Vlamings, 2007, High frequency stimulation of the subthalamic nucleus improves speed of locomotion but impairs forelimb movement in Parkinsonian rats, Neuroscience, 148, 815, 10.1016/j.neuroscience.2007.06.043 · DOI
  16. Chaniary, 2009, Quantification of gait in dystonic Gunn rats, J Neurosci Methods, 180, 273, 10.1016/j.jneumeth.2009.03.023 · DOI
  17. Yu, 2001, Gait analysis in rats with peripheral nerve injury, Muscle Nerve, 24, 231, 10.1002/1097-4598(200102)24:2<231::AID-MUS80>3.0.CO;2-5 · DOI
  18. Mabrouk, 2008, Stimulation of delta opioid receptors located in substantia nigra reticulata but not globus pallidus or striatum restores motor activity in 6-hydroxydopamine lesioned rats: new insights into the role of delta receptors in parkinsonism, J Neurochem, 107, 1647, 10.1111/j.1471-4159.2008.05727.x · DOI
  19. Fischer, 2002, Discrimination of morphine- and haloperidol-induced muscular rigidity and akinesia/catalepsy in simple tests in rats, Behav Brain Res, 134, 317, 10.1016/S0166-4328(02)00044-X · DOI
  20. Paille, 2007, Rat model of Parkinson's disease with bilateral motor abnormalities, reversible with levodopa, and dyskinesias, Mov Disord, 22, 533, 10.1002/mds.21308 · DOI
  21. Blandini, 2007, Time-course of nigrostriatal damage, basal ganglia metabolic changes and behavioural alterations following intrastriatal injection of 6-hydroxydopamine in the rat: new clues from an old model, Eur J Neurosci, 25, 397, 10.1111/j.1460-9568.2006.05285.x · DOI
  22. Yoon, 2007, Treadmill exercise suppresses nigrostriatal dopaminergic neuronal loss in 6-hydroxydopamine-induced Parkinson's rats, Neurosci Lett, 423, 12, 10.1016/j.neulet.2007.06.031 · DOI
  23. Fearnley, 1991, Ageing and Parkinson's disease: substantia nigra regional selectivity, Brain, 114, 2283, 10.1093/brain/114.5.2283 · DOI · Paper page
  24. Muir, 1999, Ground reaction forces in locomoting hemi-parkinsonian rats: a definitive test for impairments and compensations, Exp Brain Res, 126, 307, 10.1007/s002210050739 · DOI
  25. Olsson, 1995, Forelimb akinesia in the rat Parkinson model: differential effects of dopamine agonists and nigral transplants as assessed by a new stepping test, J Neurosci, 15, 3863, 10.1523/JNEUROSCI.15-05-03863.1995 · DOI · Paper page
  26. Miklyaeva, 1995, Impairments and compensatory adjustments in spontaneous movement after unilateral dopamine depletion in rats, Brain Res, 681, 23, 10.1016/0006-8993(95)00277-W · DOI
  27. Hausdorff, 1998, Gait variability and basal ganglia disorders: stride-to-stride variations of gait cycle timing in Parkinson's disease and Huntington's disease, Mov Disord, 13, 428, 10.1002/mds.870130310 · DOI · Paper page
  28. Wang, 2008, A comprehensive analysis of gait impairment after experimental stroke and the therapeutic effect of environmental enrichment in rats, J Cereb Blood Flow Metab, 28, 1936, 10.1038/jcbfm.2008.82 · DOI
  29. Marin, 2009, Effects of early vs. late initiation of levodopa treatment in hemiparkinsonian rats, Eur J Neurosci, 30, 823, 10.1111/j.1460-9568.2009.06877.x · DOI
  30. Hefti, 1980, Circling behavior in rats with partial, unilateral nigro-striatal lesions: effect of amphetamine, apomorphine, and DOPA, Pharmacol Biochem Behav, 12, 185, 10.1016/0091-3057(80)90353-6 · DOI
  31. Hudson, 1993, Correlation of apomorphine- and amphetamine-induced turning with nigrostriatal dopamine content in unilateral 6-hydroxydopamine lesioned rats, Brain Res, 626, 167, 10.1016/0006-8993(93)90576-9 · DOI · Paper page
  32. Steiner, 2001, Unilateral striatal dopamine depletion: time-dependent effects on cortical function and behavioural correlates, Eur J Neurosci, 14, 1390, 10.1046/j.0953-816x.2001.01756.x · DOI
  33. Schallert, 2000, CNS plasticity and assessment of forelimb sensorimotor outcome in unilateral rat models of stroke, cortical ablation, parkinsonism and spinal cord injury, Neuropharmacology, 39, 777, 10.1016/S0028-3908(00)00005-8 · DOI · Paper page
  34. Schneider, 1998, Differential effects of GDNF treatment on rotational asymmetry, skilled forelimb use deficits and sensory neglect in unilateral 6-OHDA-lesioned rats, Restor Neurol Neurosci, 13, 205
  35. Prentice, 2001, Contributions of the reticulospinal system to the postural adjustments occurring during voluntary gait modifications, J Neurophysiol, 85, 679, 10.1152/jn.2001.85.2.679 · DOI
  36. Ferraye, 2010, Effects of pedunculopontine nucleus area stimulation on gait disorders in Parkinson's disease, Brain, 133, 205, 10.1093/brain/awp229 · DOI · Paper page
  37. Rauch, 2010, Effect of deep brain stimulation in the pedunculopontine nucleus on motor function in the rat 6-hydroxydopamine Parkinson model, Behav Brain Res, 210, 46, 10.1016/j.bbr.2010.02.003 · DOI
  38. Nandi, 2002, Deep brain stimulation of the pedunculopontine region in the normal non-human primate, J Clin Neurosci, 9, 170, 10.1054/jocn.2001.0943 · DOI
  39. Stefani, 2007, Bilateral deep brain stimulation of the pedunculopontine and subthalamic nuclei in severe Parkinson's disease, Brain, 130, 1596, 10.1093/brain/awl346 · DOI · Paper page
  40. Breit, 2001, Unilateral lesion of the nigrostriatal pathway induces an increase of neuronal activity of the pedunculopontine nucleus, which is reversed by the lesion of the subthalamic nucleus in the rat, Eur J Neurosci, 14, 1833, 10.1046/j.0953-816x.2001.01800.x · DOI
  41. Florio, 2007, High-frequency stimulation of the subthalamic nucleus modulates the activity of pedunculopontine neurons through direct activation of excitatory fibres as well as through indirect activation of inhibitory pallidal fibres in the rat, Eur J Neurosci, 25, 1174, 10.1111/j.1460-9568.2007.05360.x · DOI
  42. Elahi, 2009, Effect of transcranial magnetic stimulation on Parkinson motor function–systematic review of controlled clinical trials, Mov. Disord., 24, 357, 10.1002/mds.22364 · DOI
  43. Fang, 2010, Review: repetitive transcranial magnetic stimulation over the human primary motor cortex for modulating motor control and motor learning, J. Med. Biol. Eng., 30, 193, 10.5405/jmbe.30.4.01 · DOI
  44. Chang, 2011, A lack of modulation of motor evoked potential in sensory-impaired individuals with spinal cord injuries, J. Med. Biol. Eng., 31, 37, 10.5405/jmbe.705 · DOI

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Metadata

Authors
Hsieh, T.-H., Chen, J.-J. J., Chen, L.-H., Chiang, P.-T., & Lee, H.-Y.
Venue
Behavioural Brain Research
Publisher
Elsevier BV
Published
2011-09
Volume
222
Issue
1
Pages
1-9
ISSN
0166-4328 (ISSN-L)
DOI
10.1016/j.bbr.2011.03.031
OpenAlex
W2171078237
Cited by
684
References
2
FWCI
83.42
Type
journal article
Language
en
Open access
bronze
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Funders
  • National Science Council
  • National Health Research Institutes of Taiwan

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CoChat. (2026). Citation check: Time-course gait analysis of hemiparkinsonian rats following 6-hydroxydopamine lesion. https://app.cochat.ai/papers/10.1016/j.bbr.2011.03.031
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Hsieh, T.-H., Chen, J.-J. J., Chen, L.-H., Chiang, P.-T., & Lee, H.-Y. (2011). Time-course gait analysis of hemiparkinsonian rats following 6-hydroxydopamine lesion. Behavioural Brain Research. https://doi.org/10.1016/j.bbr.2011.03.031

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