Prolonged elevation in hippocampal Aβ and cognitive deficits following repeated endotoxin exposure in the mouse

Kahn, Marielle S., Kranjac, Dinko, Alonzo, Chris A., Haase, Jennifer H., Cedillos, Rudy O., McLinden, Kristina A., Boehm, Gary W., Chumley, Michael J.·2012·Behavioural Brain Research
DOI 10.1016/j.bbr.2012.01.010

Cited by (177)

Items 101–177 of 177

  1. Manipulation of the diet–microbiota–brain axis in Alzheimer’s disease
    Daniel D. Lee, Virginia M.‐Y. Lee, Seong Kwon Hur · 2022 · Frontiers in Neuroscience
  2. Long-lasting neurobehavioral alterations in burn-injured mice resembling post-traumatic stress disorder in humans
    Qing-Hong Zhang, Ji-Wei Hao, Guang-Lei Li, Xiaojing Ji, Min Zhou, Yong-ming Yao · 2019 · Experimental Neurology
  3. An alkaline phosphatase transport mechanism in the pathogenesis of Alzheimer’s disease and neurodegeneration
    Adrianne F. Pike, Nynke I. Kramer, Bas J. Blaauboer, Willem Seinen, Ruud Brands · 2014 · Chemico-Biological Interactions
  4. Inflammation, Nitro-Oxidative Stress, Impaired Autophagy, and Insulin Resistance as a Mechanistic Convergence Between Arterial Stiffness and Alzheimer’s Disease
    Jhana O. Hendrickx, Wim Martinet, Debby Van Dam, Guido R.Y. De Meyer · 2021 · Frontiers in Molecular Biosciences
  5. Alzheimer's disease – the ‘microbial hypothesis’ from a clinical and neuroimaging perspective
    Lutz Frölich · 2020 · Psychiatry Research Neuroimaging
  6. Antiepileptic drug therapy and recommendations for withdrawal in patients with seizures and epilepsy due to neurocysticercosis
    Javier Arturo Bustos, Hector Hugo Garcia, Óscar H. Del Brutto · 2016 · Expert Review of Neurotherapeutics
  7. Research progress of gut microbiota and frailty syndrome
    Xiao Qin Wang, Min Wu · 2021 · Open Medicine
  8. Gut Microbiota as a Hidden Player in the Pathogenesis of Alzheimer’s Disease
    Hyunjung Choi, Dongjoon Lee, Inhee Mook‐Jung · 2022 · Journal of Alzheimer s Disease
  9. Communal interaction of glycation and gut microbes in diabetes mellitus, Alzheimer's disease, and Parkinson's disease pathogenesis
    Rahul Shivaji Patil, Rashmi Santosh Tupe · 2023 · Medicinal Research Reviews
  10. Association Between the Gut Microbiota and Alzheimer’s Disease: An Update on Signaling Pathways and Translational Therapeutics
    Rutweek Kulkarni, Sneha Kumari, Rishika Dhapola, Prajjwal Sharma, Sunil Kumar Singh, Bikash Medhi, Dibbanti HariKrishnaReddy · 2024 · Molecular Neurobiology
  11. Diet Patterns, the Gut Microbiome, and Alzheimer’s Disease
    Andrea McGrattan, Christopher James Stewart, Aedín Cassidy, Jayne V. Woodside, Claire T. McEvoy · 2022 · Journal of Alzheimer s Disease
  12. Glycation in Alzheimer’s Disease and Type 2 Diabetes: The Prospect of Dual Drug Approaches for Therapeutic Interventions
    Sama Ayoub, Maryam Arabi, Yousef A. Al-Najjar, Ibrahim Laswi, Tiago F. Outeiro, Ali Châari · 2025 · Molecular Neurobiology
  13. The Role of the Gut Microbiota and Microbial Metabolites in the Pathogenesis of Alzheimer’s Disease
    Yi Wang · 2022 · CNS & Neurological Disorders - Drug Targets
  14. Over-expression of TSPO in the hippocampal CA1 area alleviates cognitive dysfunction caused by lipopolysaccharide in mice
    Hui Zhang, Li Ma, Yanling Yin, Lian-qiang Dong, Gangge Cheng, Yaqun Ma, Yunfeng Li, Bainan Xu · 2016 · Brain Research
  15. Advances in molecular mechanisms and therapeutic strategies for central nervous system diseases based on gut microbiota imbalance
    Wei Tao, Yanren Zhang, Bingbin Wang, Saiqun Nie, Fang Li, Jian Xiao, Yanqing Wu · 2024 · Journal of Advanced Research
  16. Intermittent cytomegalovirus infection alters neurobiological metabolism and induces cognitive deficits in mice
    Mark A. A. Harrison, Sara L. Morris, Grace A. Rudman, Daniel J. Rittenhouse, Chandler H. Monk, Siva S. V. P. Sakamuri, MaryJane Jones, Md Mehedi Hasan, Mst Shamima Khatun, Hanyun Wang et al. · 2024 · Brain Behavior and Immunity
  17. Treadmill exercise can regulate the redox balance in the livers of APP/PS1 mice and reduce LPS accumulation in their brains through the gut-liver-kupffer cell axis
    Shunling Yuan, Yirong Wang, Jialun Yang, Yingzhe Tang, Weijia Wu, Xiangyuan Meng, Ye Jian, Yong Lei, Yang Liu, Chenhao Tang et al. · 2024 · Aging
  18. Lipopolysaccharide exposure during late embryogenesis triggers and drives Alzheimer‐like behavioral and neuropathological changes in CD‐1 mice
    Fang Wang, Zhe‐Zhe Zhang, Lei Cao, Qi‐Gang Yang, Qing‐Fang Lu, Gui‐Hai Chen · 2020 · Brain and Behavior
  19. Aberrant Cerebral Iron Trafficking Co-morbid With Chronic Inflammation: Molecular Mechanisms and Pharmacologic Intervention
    Shaina L. Rosenblum, Daniel J. Kosman · 2022 · Frontiers in Neurology
  20. Hippocampal sclerosis: The missing link of cysticercosis epileptogenesis?
    Óscar H. Del Brutto, Jerome Engel, Dawn S. Eliashiv, Noriko Salamon, Héctor H. García · 2014 · Epilepsia
  21. Differential Effect of Repeated Lipopolysaccharide Treatment and Aging on Hippocampal Function and Biomarkers of Hippocampal Senescence
    Jolie Barter, Ashok Kumar, Asha Rani, Luis M. Colón-Pérez, Marcelo Febo, Thomas C. Foster · 2020 · Molecular Neurobiology
  22. Peripheral administration of d-cycloserine rescues memory consolidation following bacterial endotoxin exposure
    Dinko Kranjac, Kyle M. Koster, Marielle S. Kahn, Micah J. Eimerbrink, Brent M. Womble, Brenton G. Cooper, Michael J. Chumley, Gary W. Boehm · 2013 · Behavioural Brain Research
  23. Unveiling the multifaceted pathogenesis and therapeutic drugs of Alzheimer's disease: A comprehensive review
    Liting Peng, Zhiming Zhang, Qi Li, Zhenjiang Song, Canqun Yan, Hongyan Ling · 2024 · Heliyon
  24. Gut Microorganisms and Neurological Disease Perspectives
    Nairita Ahsan Faruqui, Durdana Hossain Prium, Sadrina Afrin Mowna, Md. Asad Ullah, Yusha Araf, Bishajit Sarkar, Umme Salma Zohora, Mohammad Shahedur Rahman · 2021 · Future Neurology
  25. Human milk oligosaccharide 2′-fucosyllactose alleviates cognitive impairment via the vagal afferent pathway in Alzheimer's disease mice
    Mengzhen Jia, Xiaorui Wang, Fangjie Ning, Wenxiu Wang, Xinyu Hu, Kexin Geng, Junqing Wen, Shan Wu, Bin Wang, Zhigang Liu · 2025 · Food & Function
  26. Remifentanil suppresses increase in interleukin-6 mRNA in the brain by inhibiting cyclic AMP synthesis
    Shigeru Maeda, Tsugunobu Andoh, Rieko Onishi, Yumiko Tomoyasu, Hitoshi Higuchi, Takuya Miyawaki · 2018 · Journal of Anesthesia
  27. Advances in proteomic phenotyping of microglia in neurodegeneration
    Sydney N Sunna, Christine A Bowen, Christina C. Ramelow, Juliet V. Santiago, Prateek Kumar, Srikant Rangaraju · 2023 · PROTEOMICS
  28. Impairment of lithium chloride-induced conditioned gaping responses (anticipatory nausea) following immune system stimulation with lipopolysaccharide (LPS) occurs in both LPS tolerant and LPS non-tolerant rats
    Melissa Y.T. Chan, Shelley K. Cross-Mellor, Martin Kavaliers, Klaus‐Peter Ossenkopp · 2012 · Brain Behavior and Immunity
  29. Cocaine counteracts LPS-induced hypolocomotion and triggers locomotor sensitization expression
    Lucas Silva Tortorelli, Douglas Senna Engelke, Paula Santana Lunardi, Tadeu Mello e Souza, Jair Guilherme Santos-Junior, Carlos‐Alberto Gonçalves · 2015 · Behavioural Brain Research
  30. EEG Patterns in Patients With Calcified Neurocysticercosis With or Without Hippocampal Atrophy
    Naoum P. Issa, Mark J. Sedler, Víctor J. Del Brutto, Elizabeth Darsan, Lucía Milla, Jessica Montes, Mauricio Zambrano, Óscar H. Del Brutto · 2018 · Journal of Clinical Neurophysiology
  31. Targeting Toll-like Receptor 4/Nuclear Factor-κB and Nrf2/Heme Oxygenase-1 Crosstalk via Trimetazidine Alleviates Lipopolysaccharide-Induced Depressive-like Behaviors in Mice
    Sarah S. Mohamed, Nora O. Abdel Rasheed, Weam W. Ibrahim, Nesma A. Shiha · 2024 · Journal of Neuroimmune Pharmacology
  32. The synergistic interplay between vitamin A, dietary fiber, and the microbiota-gut-brain axis: a potential mechanism for preventing Alzheimer’s disease
    Shadt Skawratananond, Grace E. McCrea, Paul E. Lie, Matthew B Buxton, Sean P. Daly, Nicholas A. Vojtkofsky, Shane C Smith, Charlie Zhang, Matthew Hernandez, Ashly Hindle et al. · 2025 · American Journal of Physiology-Gastrointestinal and Liver Physiology
  33. Preventive Effect of Saccharomyces boulardii on Memory Impairment Induced by Lipopolysaccharide in Rats
    Fatemeh Babaei, Mohammadreza Mirzababaei, Leila Dargahi, Zahra Shahsavari, Marjan Nassiri‐Asl, Saeed Karima · 2022 · ACS Chemical Neuroscience
  34. TSPO ligand etifoxine attenuates LPS-induced cognitive dysfunction in mice
    Hui Zhang, Li Ma, Wen-zhi Guo, Lin-bo Jiao, Hongyu Zhao, Yaqun Ma, Xuemei Hao · 2020 · Brain Research Bulletin
  35. Unravelling the Alzheimer's pathogenesis: Molecular and cellular pathways to neurodegeneration and therapeutic targets.
    Payal Chauhan, Karan Wadhwa, Govind Singh · 2025 · Pathology, Research and Practice
  36. A Mediterranean-style diet protects against cognitive and behavioral deficits, adiposity, and Alzheimer's disease-related markers, compared to a macronutrient-matched typical American diet in C57BL/6J mice
    Paige N Braden-Kuhle, Vivienne A. Lacy, Kelly N Brice, Morgan E Bertrand, Hatice Buse Uras, Catherine Shoffner, Bridgette E Fischer, Ashish Rana, Jada L. Willis, Gary W. Boehm et al. · 2025 · Journal of Alzheimer s Disease
  37. Microglial and neuronal fates following inhibition of CSF-1R in synucleinopathy mouse model
    Michiyo Iba, Yeon‐Joo Lee, Liam Horan-Portelance, Katherine Chang, Marcell P. Szabo, Robert A. Rissman, Sungyong You, Eliezer Masliah, Changyoun Kim · 2024 · Brain Behavior and Immunity
  38. Epilepsy, interictal EEG abnormalities and hippocampal atrophy in patients with calcified neurocysticercosis: a population study in an endemic milieu
    Óscar H. Del Brutto, Robertino M. Mera, Shasha Wu, Bettsy Y. Recalde, Naoum P. Issa · 2021 · Epileptic Disorders
  39. Importance of Gut Microbiota Dysbiosis and Circadian Disruption–Associated Biomarkers in Emergence of Alzheimer’s Disease
    Simranjit Kaur, Deepali Kumari, Manoj P. Dandekar · 2025 · Molecular Neurobiology
  40. Possible Prophylactic Effects of Sulforaphane on LPS-Induced Recognition Memory Impairment Mediated by Regulating Oxidative Stress and Neuroinflammatory Proteins in the Prefrontal Cortex Region of the Brain
    Noor Ahmed Alzahrani, Khulud Abdullah Bahaidrah, Rasha Abdulrashed Mansouri, Rahaf Saeed Aldhahri, Gamal Said Abd El-Aziz, Badrah Saeed Ali Alghamdi · 2024 · Biomedicines
  41. The α5-GABAAR inverse agonist MRK-016 upregulates hippocampal BDNF expression and prevents cognitive deficits in LPS-treated mice, despite elevations in hippocampal Aβ
    Micah J. Eimerbrink, Robert Pendry, Samantha L. Hodges, J.D. Wiles, Julia L. Peterman, Jordon D. White, Hailey B. Hayes, Michael J. Chumley, Gary W. Boehm · 2018 · Behavioural Brain Research
  42. A role of human microbiota in the development of neurodegenerative diseases
    I.V. Epishina, Elena V. Budanova · 2022 · S S Korsakov Journal of Neurology and Psychiatry
  43. Gut Microbiota Dysbiosis and Neuroinflammation in Alzheimer’s Disease: a Systematic Review of Mechanistic Insights
    Sofia Katsigianni, Effrosyni Koutsouraki · 2026 · Molecular Neurobiology
  44. Alterations of the gut microbiota in patients with immunoglobulin light chain amyloidosis
    Jipeng Yan, Jin Zhao, Xiaoxuan Ning, Yunlong Qin, Yan Xing, Yuwei Wang, Qing Jia, Boyong Huang, Rui Ma, Changhui Lei et al. · 2022 · Frontiers in Immunology
  45. Characterization of Spatial Learning and Sickness Responses in Aging Rats Following Recurrent Lipopolysaccharide Administration
    Barbara J. Kupferschmid, Pamela Johnson Rowsey, Michael Riviera · 2019 · Biological Research For Nursing
  46. Exploring the Synergistic Action of Medium-Chain Triglycerides and Omega-3 Fatty Acids to Enhance Cellular Uptake and Anti-Inflammatory Responses
    Camila Kaminskas Fernandes Isern, Yao Chen, Roni Touboul, Benjamin Frank, Saidi Hu, Chuchun L. Chang · 2025 · Nutrients
  47. Hippocampal Aβ expression, but not phosphorylated tau, predicts cognitive deficits following repeated peripheral poly I:C administration
    Jordon D. White, Micah J. Eimerbrink, Hailey B. Hayes, Amy Hardy, Erin A. Van Enkevort, Julia L. Peterman, Michael J. Chumley, Gary W. Boehm · 2016 · Behavioural Brain Research
  48. The complex of gut microbial metabolites and sex hormones in Alzheimer’s disease
    Aisa Bahar, Meisam Khazaei, Hamed Tahmasebi · 2026 · Seminars in Immunopathology
  49. Acute and Chronic Lipopolysaccharide-Induced Stress Changes Expression of Proinflammatory Cytokine Genes in the Rat Brain Region-Specifically and Affects Learning and Memory
    М. И. Зайченко, Pavel Philenko, V. V. Sidorina, Grigory A. Grigoryan · 2023 · Biochemistry (Moscow)
  50. The roles of functional bacterial amyloids in neurological physiology and pathophysiology: Pros and cons for neurodegeneration
    Hossein Halimi, Behrooz Ahmadi, Nastaran Asri, Mohammad Rostami‐Nejad, Hamidreza Houri · 2025 · Microbial Pathogenesis
  51. Intraventricular murine Aβ infusion elicits hippocampal inflammation and disrupts the consolidation, but not retrieval, of conditioned fear in C57BL6/J mice.
    J. D. White, Catherine M. Urbano, J. O. Taylor, Julia L. Peterman, M. Cooksey, M. Eimerbrink, M. Eriksson, B. Cooper, M. Chumley, G. Boehm · 2020 · Behavioural Brain Research
  52. Amyloid, Crohn’s disease, and Alzheimer’s disease - are they linked?
    Anna Duda-Madej, Jakub Stecko, Natalia Szymańska, Agnieszka Miętkiewicz, Marta Szandruk-Bender · 2024 · Frontiers in Cellular and Infection Microbiology
  53. Dynamic interplay of frontoparietal cholinergic innervation and cortical reorganization in the regulation of attentional capacities in aging
    Brittney Yegla, Surbhi Joshi, Jacob Strupp, Vinay Parikh · 2021 · Neurobiology of Aging
  54. BET protein inhibitor JQ1 reduces inflammation and hippocampal amyloid-β level without altering Tau phosphorylation in LPS-challenged adult wild-type mice
    Marta Matuszewska, Magdalena Cieślik, Dorota Sulejczak, Anna Wilkaniec, Grzegorz Arkadiusz Czapski · 2026 · Brain Research
  55. Systemic inflammation, delirium and clinical progression in mild-moderate Alzheimer disease
    Adam H. Dyer, Helena Dolphin, Laura Morrison, Tara Kenny, Padraic G. Fallon, Colm M. Cunningham, Antoinette O’Connor, BRIAN A. LAWLOR, Cliona O’Farrelly, Nollaig M. Bourke et al. · 2026 · EBioMedicine
  56. The effects of derivatives of pantothenic acid on free-radical processes and the corticosterone level in the hippocampus and neocortex of rats after interoceptive stress
    M. Yu. Stepanichev, Mikhail V. Onufriev, А. К. Пискунов, Yu. V. Moiseeva, Н. А. Лазарева, А. Г. Мойсеенок, P. V. Gusev, Natalia V. Gulyaeva · 2013 · Neurochemical Journal
  57. Зв’язок між мікробіомом кишечника та розвитком нейродегенеративних захворювань (огляд)
    Володимир Павлович Широбоков, Галина Семенівна Димент · 2024 · Visnik Nacional noi academii nauk Ukrai ni
  58. Saccharomyces boulardii Ameliorates LPS-Induced Amyloidogenesis in Rats
    Ghazaleh Mohammadi, Fatemeh Babaei, Faezeh Golpour, Fatemeh Sadat Rashidi, Shiva Ghafghazi, Leila Dargahi, Marjan Nassiri‐Asl · 2024 · Probiotics and Antimicrobial Proteins
  59. Effects of an Enriched Environment on Learning and Memory in the Morris Water Maze in Rats with Acute and Chronic Proinflammatory Stress
    М. И. Зайченко, V. V. Sidorina, G. A. Grigoryan · 2025 · Neuroscience and Behavioral Physiology
  60. Acute and chronic lipopolysaccharide-induced stress changes expression of proinflammatory cytokine genes in the rat brain region-specifically and affects learning and memory
    М. И. Зайченко, Pavel Philenko, V. V. Sidorina, G. A. Grigoryan · 2023 · Biochemistry (Moscow)
  61. The microbiome: what a neurologist needs to know
    Anna B Dehghanizai, Christopher James Stewart, Rhys Huw Thomas · 2025 · Practical Neurology
  62. THE EFFECT OF HIGH-FAT, WESTERN DIET VS. PLANT-BASED, MEDITERRANEAN DIET ON ALZHEIMER’S PATHOLOGY IN MICE
    Claire Munster · 2020
  63. Memory deficits in males and females long after subchronic immune challenge
    Daria Tchessalova, Natalie Celia Tronson · 2018 · bioRxiv (Cold Spring Harbor Laboratory)
  64. Alleviation of central accumulation of amyloid-beta and prevention of cognitive dysfunction following peripheral inflammation
    Marielle Kahn Weintraub · 2014
  65. EFFECTS OF IMATINIB METHANESULFONATE ON INFLAMMATION-INDUCED AMYLOID-BETA PRODUCTION
    Courtney M. Bisson · 2015
  66. The Effects of the Omega Three Fatty Acid, DHA, on Raw 264.7 Macrophage Cells
    Alex Sanders · 2016
  67. Long-Lasting Memory Impairments after Subchronic Immune Challenge
    Daria Tchessalova · 2019 · Deep Blue (University of Michigan)
  68. Modulation of Gut Microbiota through Mediterranean Diet as a New Insight for the Alzheimer's Disease Therapy
    Alessa Fahira, Hansel Tengara Widjaja, Nathaniel Aditya · 2019 · Journal of Asian Medical Students Association
  69. Bacterial Endotoxins and Neurological Disorders: From Exposure to Therapeutic Interventions
    Yusra Habib Khan, Aroosa Liaqat, Tauqeer Hussain Mallhi, Arooj Abid, Nasser Hadal Alotaibi, Amjad Khan · 2021 · Emerging contaminants and associated treatment technologies
  70. The effect of reminder focused positive psychiatry suicide safety (RFPP-S) on COVID-19 related PTSD with PGD
    N. Ahmadi, Alan M. Steinberg, Robert S. Pynoos · 2021 · Brain Behavior and Immunity
  71. References
    2018 · Elsevier eBooks
  72. Study on the Mechanism of Intestinal Microbiota in Alzheimer’s Disease
    土玲 车 · 2022 · Advances in Microbiology
  73. Les effets positifs et négatifs du microbiote sur le développement de la démence et le rôle de la transplantation fécale
    Kyriacos Evangelou, M. Halkas, A. Theodorou, Sofia Rozani, Chrysovalanto Louka, P. Angeli · 2024 · NPG. Neurologie, psychiatrie, gériatrie/NPG
  74. A Neuroinflammatory View of Alzheimer’s Disease
    Hymie Anisman, Shawn P. Hayley, Alexander Kusnecov · 2024 · Elsevier eBooks
  75. References
    2024 · Elsevier eBooks
  76. The influence of enriched environment on learning and memory in the Morris water maze in rats with acute and chronic pro-inflammatory stress
    М. И. Зайченко, V. V. Sidorina, G. A. Grigoryan · 2024 · Журнал высшей нервной деятельности им И П Павлова
  77. Cognitive dysfunction resulting in telomere degradation: the potential of probiotics as a supplement
    Jancy M. Sekar, Venkataraman Prabhu, Prasanth Subramanian, Mohanraj Nehru, Arunan Subbiah · 2025 · Elsevier eBooks