Stimulation of postsynapse adrenergic α2A receptor improves attention/cognition performance in an animal model of attention deficit hyperactivity disorder
Abstract
A 5-trial inhibitory avoidance test using spontaneously hypertensive rat (SHR) pups has been used as an animal model of attention deficit hyperactivity disorder (ADHD). However, the roles of noradrenergic systems, which are involved in the pathophysiology of ADHD, have not been investigated in this model. In the present study, the effects of adrenergic α2 receptor stimulation, which has been an effective treatment for ADHD, on attention/cognition performance were investigated in this model. Moreover, neuronal mechanisms mediated through adrenergic α2 receptors were investigated. We evaluated the effects of both clonidine, a non-selective adrenergic α2 receptor agonist, and guanfacine, a selective adrenergic α2A receptor agonist, using a 5-trial inhibitory avoidance test with SHR pups. Juvenile SHR exhibited a shorter transfer latency, compared with juvenile Wistar Kyoto (WKY) rats. Both clonidine and guanfacine significantly prolonged the transfer latency of juvenile SHR. The effects of clonidine and guanfacine were significantly blocked by pretreatment with an adrenergic α2A receptor antagonist. In contrast, the effect of clonidine was not attenuated by pretreatment with an adrenergic α2B receptor antagonist, or an adrenergic α2C receptor antagonist, while it was attenuated by a non-selective adrenergic α2 receptor antagonist. Furthermore, the effects of neither clonidine nor guanfacine were blocked by pretreatment with a selective noradrenergic neurotoxin. These results sug…
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Systemic administration of guanfacine improves attentional performance in a rat model of ADHD, Spontaneously Hypertensive rats.
“Systemic administration of guanfacine also improves attentional performance in a rat model of ADHD, Spontaneously Hypertensive rats”
From Guanfacine’s mechanism of action in treating prefrontal cortical disorders: Successful translation across species (2020) · cites this paper as Kawaura et al., 2014
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References 35 · Cited by 29
- Authors
- Kawaura, K., Karasawa, J.-I., Chaki, S., & Hikichi, H.
- Affiliations
- Taisho Pharmaceutical (Japan) (JP)
- Corresponding author
- Hikichi, Hirohiko
- ORCID
- Chaki, Shigeyuki
- Venue
- Behavioural Brain Research
- Publisher
- Elsevier BV
- Published
- 2014-08
- Volume
- 270
- Pages
- 349-356
- ISSN
- 0166-4328 (ISSN-L)
- OpenAlex
- W1995384231
- Cited by
- 29
- References
- 35
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 4 · 2021: 1 · 2020: 3 · 2019: 3 · 2018: 3 · 2017: 2 · 2016: 4 · 2015: 2 · 2014: 1
- FWCI
- 2.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioural Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- attention deficit hyperactivity disorder, clonidine, guanfacine, spontaneously hypertensive rats, passive avoidance, noradrenergic system, receptor selectivity, young rats
- MeSH terms
- Adrenergic alpha-Agonists, Animals, Attention, Attention Deficit Disorder with Hyperactivity, Avoidance Learning, Clonidine, Cognition, Disease Models, Animal, Inhibition, Psychological, Male, Neuropsychological Tests, Rats, Inbred SHR, Rats, Inbred WKY, Guanfacine, Treatment Outcome, Rats, Adrenergic alpha-2 Receptor Agonists
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