Antidepressant administration modulates stress-induced DNA methylation and DNA methyltransferase expression in rat prefrontal cortex and hippocampus

Sales, Amanda J.; Joca, Sâmia R.L.

doi:10.1016/j.bbr.2018.01.022

Antidepressant administration modulates stress-induced DNA methylation and DNA methyltransferase expression in rat prefrontal cortex and hippocampus

HIGHLIGHTSFootshock exposure increased DNA methylation in dHPC and PFC.Footshock exposure increased DNMT levels in dHPC and PFC.Imipramine treatment attenuated LH behavior and DNA methylation changes induced by footshocks. ABSTRACT Stress and antidepressant treatment can modulate DNA methylation …