Resveratrol glycoside mediates microglial endoplasmic reticulum stress to mitigate LPS-induced sepsis-associated cognitive dysfunction

Yin, Yi; Lv, Guoguang; Zhang, Wang; Yuan, Jing; Yang, Yakun; Wang, Yushui; Liu, Shuai; Wang, Shan; Yan, Bin; Bo, Hai; Ye, Chaoqun

doi:10.1016/j.bbr.2023.114326

Resveratrol glycoside mediates microglial endoplasmic reticulum stress to mitigate LPS-induced sepsis-associated cognitive dysfunction

BACKGROUND As a common complication of sepsis, sepsis-associated encephalopathy (SAE) is characterized by diffuse brain dysfunction and neurological damage and closely associated with long-term cognitive dysfunction. The dysregulated host response triggered by neurotoxicity of microglia is an imp…