Sumoylation increases HIF-1α stability and its transcriptional activity

Bae, Seong-Hui, Jeong, Joo-Won, Park, Jeong Ae, Kim, Se-Hee, Bae, Moon-Kyoung, Choi, Soo-Joon, Kim, Kyu-Won·2004·Biochemical and Biophysical Research Communications

Cited by (231)

Items 101–200 of 231

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    Zheng Xu, Ho‐Yin Chan, Wai Ling Macrina Lam, Kwok Ho Lam, Levina Suk Mi Lam, Tzi Bun Ng, Shannon Wing Ngor Au · 2009 · Antioxidants and Redox Signaling
  2. Overexpression of SKI Oncoprotein Leads to p53 Degradation through Regulation of MDM2 Protein Sumoylation
    Boxiao Ding, Yin Sun, Jiaoti Huang · 2012 · Journal of Biological Chemistry
  3. Hypoxia-inducible factors: Crosstalk between their protein stability and protein degradation
    Wei Wei, Xiao Dan Yu · 2007 · Cancer Letters
  4. Hypoxia Triggers SENP1 (Sentrin-Specific Protease 1) Modulation of KLF15 (Kruppel-Like Factor 15) and Transcriptional Regulation of Arg2 (Arginase 2) in Pulmonary Endothelium
    Deepesh Pandey, Yohei Nomura, Max C. Rossberg, Daijiro Hori, Anil Bhatta, Gizem Keceli, Thorsten Martin Leucker, Lakshmi Santhanam, Larissa A. Shimoda, Dan E. Berkowitz et al. · 2018 · Arteriosclerosis Thrombosis and Vascular Biology
  5. Interleukin-6 (IL-6) triggers the malignancy of hemangioma cells via activation of HIF-1α/VEGFA signals
    Xiaoyang Fu, Shuiting Zhai, Yuan Ji · 2018 · European Journal of Pharmacology
  6. Sumoylation of Hypoxia-Inducible Factor-1α Ameliorates Failure of Brain Stem Cardiovascular Regulation in Experimental Brain Death
    Julie Y.H. Chan, Ching‐Yi Tsai, Carol Hsin‐Yi Wu, Faith C. H. Li, Kuang‐Yu Dai, Enya Y. H. Sun, Samuel H.H. Chan, Alice Y. Chang · 2011 · PLoS ONE
  7. SUMOylation Fine-Tunes Endothelial HEY1 in the Regulation of Angiogenesis
    Ruizhe Ren, Sha Ding, Kefan Ma, Yuan‐Qing Jiang, Yiran Wang, Junbo Chen, Yunyun Wang, Yaohui Kou, Fan Xiao, Xiaolong Zhu et al. · 2024 · Circulation Research
  8. Emerging role of SUMOylation in placental pathology
    Dora Baczyk, Sascha Drewlo, John C. Kingdom · 2013 · Placenta
  9. Hypoxia and hypoxia-inducible factors in chronic kidney disease
    Shinji Tanaka, Tetsuhiro Tanaka, Masaomi Nangaku · 2016 · Renal Replacement Therapy
  10. Mutual antagonism between aryl hydrocarbon receptor and hypoxia-inducible factor-1α (AhR/HIF-1α) signaling: Impact on the aging process
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  11. Chapter 7 Small Ubiquitin‐Like Modifiers in Cellular Malignancy and Metastasis
    Keun Il Kim, Sung Hee Baek · 2009 · International review of cytology
  12. Mitochondrial dysfunction-induced high hCG associated with development of fetal growth restriction and pre-eclampsia with fetal growth restriction
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  13. The Roles of SUMO in Metabolic Regulation
    E. Kamynina, P. Stover · 2017 · Advances in Experimental Medicine and Biology
  14. Sumoylation of hypoxia inducible factor-1α and its significance in cancer
    Jie Li, Ying Xu, Huike Jiao, Wei Wang, Zhu Mei, Guoqiang Chen · 2014 · Science China Life Sciences
  15. SUMOylation Attenuates Sensitivity toward Hypoxia- or Desferroxamine-Induced Injury by Modulating Adaptive Responses in Salivary Epithelial Cells
    Ha‐Van Nguyen, Jo-Lin Chen, Jenny Zhong, Kwang‐Jin Kim, Edward D. Crandall, Zea Borok, Yuan Chen, David Kong Ann · 2006 · American Journal Of Pathology
  16. Differential in-gel electrophoresis (DIGE) analysis of human bone marrow osteoprogenitor cell contact guidance
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  17. Emerging roles of SUMO modification in arthritis
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  18. Hypoxia‐inducible factors – regulation, role and comparative aspects in tumourigenesis
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  19. SENP-1 enhances hypoxia-induced proliferation of rat pulmonary artery smooth muscle cells by regulating hypoxia-inducible factor-1α
    Fang Zhou, Aiguo Dai, Yong‐Liang Jiang, Xiaowu Tan, Xiufeng Zhang · 2016 · Molecular Medicine Reports
  20. Acetylation‐mediated Siah2 stabilization enhances PHD3 degradation in Helicobacter pylori‐infected gastric epithelial cancer cells
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  21. SUMO Teams up with Ubiquitin to Manage Hypoxia
    Helle D. Ulrich · 2007 · Cell
  22. Bacterially produced human HIF-1α is competent for heterodimerization and specific DNA-binding
    Georgia Chachami, Efrosyni Paraskeva, Eleni Georgatsou, Sofia Bonanou, George Simos · 2005 · Biochemical and Biophysical Research Communications
  23. NER-factor DDB2 regulates HIF1α and hypoxia-response genes in HNSCC
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  24. RSUME inhibits VHL and regulates its tumor suppressor function
    Juan Gerez, Lucas Tedesco, Juán José Bonfiglio, Mariana Fuertes, Marta Barontini, Susana Silberstein, Yonghe Wu, Ulrich Renner, Marcelo Páez-Pereda, F Holsboer et al. · 2014 · Oncogene
  25. SUMO, hypoxia and the regulation of metabolism
    Terence A. Agbor, Cormac T. Taylor · 2008 · Biochemical Society Transactions
  26. SENP3-FIS1 axis promotes mitophagy and cell survival under hypoxia
    Alice Zhao, Laura Maple, Juwei Jiang, Katie N. Myers, Callum G. Jones, Hannah Gagg, Connor L McGarrity-Cottrell, Ola Rominiyi, Spencer James Collis, Greg Wells et al. · 2024 · Cell Death and Disease
  27. Methyltransferase SMYD3 impairs hypoxia tolerance by augmenting hypoxia signaling independent of its enzymatic activity
    Zixuan Wang, Xiaoyun Chen, Sijia Fan, Chunchun Zhu, Hongyan Deng, Jinhua Tang, Xueyi Sun, Shuke Jia, Qian Liao, Wuhan Xiao et al. · 2022 · Journal of Biological Chemistry
  28. The emerging roles of SUMOylation in pulmonary diseases
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  29. HIF-1α SUMOylation affects the stability and transcriptional activity of HIF-1α in human lens epithelial cells
    Xiao Lian Han, Xinling Wang, Li Qin, Xiaoxuan Dong, Jin-Song Zhang, Qi-Chang Yan · 2015 · Graefe s Archive for Clinical and Experimental Ophthalmology
  30. JNK Contributes to Hif-1α Regulation in Hypoxic Neurons
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  31. Suppression of HIF-1α by Valproic Acid Sustains Self-Renewal of Mouse Embryonic Stem Cells under Hypoxia In Vitro
    HJ Lee, Kyu‐Won Kim · 2012 · Biomolecules & Therapeutics
  32. Dynamic regulation of HIF1Α stability by SUMO2/3 and SENP3 in the human placenta
    Jayonta Bhattacharjee, Sruthi Alahari, Julien Sallais, Andrea Tagliaferro, Martin Post, Isabella Caniggia · 2016 · Placenta
  33. Transient ischemia induces massive nuclear accumulation of SUMO2/3-conjugated proteins in spinal cord neurons
    Zhuoran Wang, R Wang, Huaxin Sheng, Siyuan P. Sheng, Wulf Paschen, Wei Yang · 2012 · Spinal Cord
  34. Host cell sumoylation level influences papillomavirus E2 protein stability
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  35. Ginkgolic acid improves bleomycin‐induced pulmonary fibrosis by inhibiting SMAD4 SUMOylation
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  36. The role of hypoxia inducible factor-1 in cell metabolism – a possible target in cancer therapy
    Rachida S. Bel Aiba, Elitsa Y. Dimova, Agnes Görlach, Thomas Kietzmann · 2006 · Expert Opinion on Therapeutic Targets
  37. The regulation of Hypoxia-Inducible Factor-1 (HIF-1alpha) expression by Protein Disulfide Isomerase (PDI)
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  38. Merlin sumoylation is required for its tumor suppressor activity
    Qi Qi, X Liu, Daniel Jay Brat, Kai-Ning Ye · 2013 · Oncogene
  39. SUMO conjugation and cardiovascular development
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  40. The Effect of HIF-1α siRNA on Growth and Chemosensitivity of Mia-paca Cell Line
    Lily P H Yang, Won Kyung Kang · 2008 · Yonsei Medical Journal
  41. The expression of hypoxia-inducible factor-1α gene is not affected by low-oxygen conditions in yellow perch (Perca flavescens) juveniles
    Karolina Kwasek, Simona Rimoldi, Anna Giulia Cattaneo, Timothy Parker, Konrad R Dabrowski, Genciana Terova · 2017 · Fish Physiology and Biochemistry
  42. Increased SUMO-activating enzyme subunit 1 promotes glycolysis and fibrotic phenotype of diabetic nephropathy
    Reziwanguli Wusiman, Shayila Haimiti, Hanikezi Abuduaini, Miaoyan Yang, Yitian Wang, Meijun Gu, Ali Sailike, Lei Gao · 2025 · Biochemical Pharmacology
  43. SENP2-mediated SERCA2a deSUMOylation increases calcium overload in cardiomyocytes to aggravate myocardial ischemia/reperfusion injury
    Yuanyuan Luo, Shuaishuai Zhou, Tao Xu, Wanling Wu, Pingping Shang, Shuai Wang, Defeng Pan, Dongye Li · 2023 · Chinese Medical Journal
  44. Down-regulation of SENP1 Expression Increases Apoptosis of Burkitt Lymphoma Cells
    Binbin Huang, Qing-mei Gao, Wei Liang, Bing Xiu, Wenjun Zhang, Aibin Liang · 2012 · Asian Pacific Journal of Cancer Prevention
  45. RNA-binding proteins in degenerative joint diseases: A systematic review
    Min Xiang, Ling Liu, Tingrui Wu, Bo Wei, Huan Liu · 2023 · Ageing Research Reviews
  46. Perspective in Chronic Kidney Disease: Targeting Hypoxia-Inducible Factor (HIF) as Potential Therapeutic Approach
    Aaishwarya B. Deshmukh, Jayvadan K. Patel, Ashish R. Prajapati, Shreya Shah · 2012 · Renal Failure
  47. PKC-δ inhibitors sustain self-renewal of mouse embryonic stem cells under hypoxiain vitro
    HJ Lee, Chul‐Ho Jeong, Jong‐Ho Cha, Kyu-Won Kim · 2010 · Experimental & Molecular Medicine
  48. SYT-SSX1 (Synovial Sarcoma Translocated) Regulates PIASy Ligase Activity to Cause Overexpression of NCOA3 Protein
    Yin Sun, Juanita Perera, Brian P. Rubin, Jiaoti Huang · 2011 · Journal of Biological Chemistry
  49. SUMOylation mediates the disassembly of the Smad4 nuclear export complex via RanGAP1 in KELOIDS
    Xiaohu Lin, Qianqian Pang, Jie Hu, Jiaqi Sun, Siya Dai, Yijia Yu, Jinghong Xu · 2023 · Journal of Cellular and Molecular Medicine
  50. SUMOylation indirectly suppresses activity of the HIF-1α pathway in intestinal epithelial cells
    Mykyta I. Malkov, Darragh Flood, Cormac T. Taylor · 2023 · Journal of Biological Chemistry
  51. MITF regulates the subcellular location of HIF1α through SUMOylation to promote the invasion and metastasis of daughter cells derived from polyploid giant cancer cells
    Minying Zheng, Shifeng Tian, Xinyue Zhou, Man Yan, Ming‐Ming Zhou, Yongjun Yu, Yue Zhang, Xiaorui Wang, Na Li, Li Ren et al. · 2024 · Oncology Reports
  52. USP38 promotes deubiquitination of K11-linked polyubiquitination of HIF1α at Lys769 to enhance hypoxia signaling
    Rui Wang, Xiaolian Cai, Xiong Li, Jun Li, Xing Liu, Jing Wang, Wuhan Xiao · 2023 · Journal of Biological Chemistry
  53. Tumor Hypoxia and Targeted Gene Therapy
    Olga Greco, Simon D. Scott · 2007 · International review of cytology
  54. ING1b negatively regulates HIF1α protein levels in adipose-derived stromal cells by a SUMOylation-dependent mechanism
    Nicolas Bigot, Claire Guérillon, S Loisel, Nicolas Bertheuil, Luc Sensebé, Karin Tarte, Rémy Pedeux · 2015 · Cell Death and Disease
  55. Ubiquitination is absolutely required for the degradation of hypoxia-inducible factor - 1 alpha protein in hypoxic conditions
    Ronghai Wang, Ping Zhang, Jinhang Li, Hongzai Guan, Guangjun Shi · 2016 · Biochemical and Biophysical Research Communications
  56. Deciphering the SUMO code in the kidney
    Zhen Lu Yang, Yuming Zhang, Shiren Sun · 2018 · Journal of Cellular and Molecular Medicine
  57. Lessons from Comparison of Hypoxia Signaling in Plants and Mammals
    Catherine M. Doorly, Emmanuelle Graciet · 2021 · Plants
  58. Renal insufficiency and chronic kidney disease – Promotor or consequence of pathological post-translational modifications
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  59. Heme oxygenase-1 plays a pro-life role in experimental brain stem death via nitric oxide synthase I/protein kinase G signaling at rostral ventrolateral medulla
    Kuang‐Yu Dai, Samuel H.H. Chan, Alice Y. Chang · 2010 · Journal of Biomedical Science
  60. Roles of Ubiquitination and SUMOylation in the Regulation of Angiogenesis
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  61. Hypoxia-inducible factor-1α as prognostic marker
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  62. Spring viremia of carp virus infection induces hypoxia response in zebrafish by stabilizing hif1α
    Zixuan Wang, Chunchun Zhu, Xueyi Sun, Hongyan Deng, Wen Liu, Shuke Jia, Yao Bai, Wuhan Xiao, Xing Liu · 2024 · Journal of Virology
  63. MYLIP attenuates hypoxia tolerance by inducing K27-linked polyubiquitination and subsequent proteasomal degradation of HIF-α
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  64. Hypoxia and Reactive Oxygen Species
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  65. A closer look at the role of deubiquitinating enzymes in the Hypoxia Inducible Factor pathway
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  66. Zebrafish usp3 loss promotes hypoxic tolerance by disrupting deubiquitination of K63-polyubiquitinated hif-1αa
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  67. Evolution of a novel regulatory mechanism of hypoxia inducible factor in hypoxia-tolerant electric fishes
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  68. Unravelling the molecular interplay: SUMOylation, PML nuclear bodies and vascular cell activity in health and disease
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  70. Tumour Hypoxia and the Hypoxia-Inducible Transcription Factors: Key Players in Cancer Progression and Metastasis
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