MicroRNA expression profiles in head and neck cancer cell lines
Abstract
Non-coding RNA molecules such as microRNAs (miRNAs) may play an important role in human carcinogenesis. Their expression has been profiled in many human cancers but there are few published studies in head and neck cancer. In this study, the relative expression of 261 mature miRNA genes was determined in nine head and neck cancer cell lines using an oligonucleotide array platform. Thirty-three miRNAs in the array were found to be highly expressed and 22 showed low levels of expression in all cell lines. Notable was the high expression of miR-21 and miR-205. Expression of several miRNAs was validated using Northern blot analysis. Potential targets of validated miRNAs included tumor suppressor genes, kinesin family member 1B isoform alpha (KIF1B), and hypermethylated in cancer 2 (HIC2), and pleomorphic adenoma gene 1 (PLAG1). This study provides the largest genomewide survey of mature miRNA transcripts in head and neck cancer cell lines.
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miR-21 expression is increased in glioblastoma, head and neck carcinomas, ovarian cancer, B-cell lymphoma, hepatocellular, and cervical carcinoma.
“Further miRNA profiling in tumor samples and cancer cell lines show increased miR-21 expression in glioblastoma (Chan et al., 2005; Ciafre et al., 2005), head and neck carcinomas (Tran et al., 2007), ovarian cancer (Iorio et al., 2007), B-cell lymphoma (Lawrie et al., 2007), hepatocellular (Meng et al., 2007), and cervical carcinoma (Lui et al., 2007).”
From Modulation of K-Ras-Dependent Lung Tumorigenesis by MicroRNA-21 (2010) · cites this paper as Tran et al., 2007
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References 33 · Cited by 275
- Authors
- Tran, N., McLean, T., Zhang, X., Zhao, C. J., Thomson, J. M., O’Brien, C., & Rose, B.
- Affiliations
- The University of Sydney (AU)
- Royal Prince Alfred Hospital (AU)
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Tran, Nham
- Venue
- Biochemical and Biophysical Research Communications
- Publisher
- Elsevier BV
- Published
- 2007-06
- Volume
- 358
- Issue
- 1
- Pages
- 12-17
- ISSN
- 0006-291X (ISSN-L)
- OpenAlex
- W2017714432
- Cited by
- 275
- References
- 33
- Citations by year
- 2025: 3 · 2024: 5 · 2023: 6 · 2022: 1 · 2021: 9 · 2020: 11 · 2019: 5 · 2018: 10 · 2017: 14 · 2016: 9 · 2015: 16 · 2014: 21 · 2013: 22 · 2012: 22
- FWCI
- 11.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochemical and Biophysical Research Communications (publishedVersion)
- PubMed (publishedVersion)
- UTS ePRESS (University of Technology Sydney) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Health Sciences › Medicine › Otorhinolaryngology › Head and Neck Cancer Studies
- Keywords
- microRNA expression, head and neck cancer, cancer cell lines, miR-21, miR-205, miRNA target genes, tumor suppressor, KIF1B, PLAG1, non-coding RNA, carcinogenesis
- MeSH terms
- DNA-Binding Proteins, Head and Neck Neoplasms, Humans, Nerve Tissue Proteins, Biomarkers, Tumor, Gene Expression Regulation, Neoplastic, Kinesins, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling, MicroRNAs, Cell Line, Tumor
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