TRAF6 ubiquitin ligase is essential for RANKL signaling and osteoclast differentiation

Lamothe, Betty, Webster, William K., Gopinathan, Ambily, Besse, Arnaud, Campos, Alejandro D., Darnay, Bryant G.·2007·Biochemical and Biophysical Research Communications

Cited by (134)

Items 101–134 of 134

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  2. Anti-inflammatory, but not osteoprotective, effect of the TRAF6/CD40 inhibitor 6877002 in rodent models of local and systemic osteolysis
    Silvia Marino, Nicole Hannemann, Ryan T. Bishop, F. Zeng, Giovana Carrasco, Sandrine Meurisse, Boya Li, Antonia Sophocleous, Anna Sparatore, Tobias Bäuerle et al. · 2021 · Biochemical Pharmacology
  3. Morusin Inhibits RANKL-induced Osteoclastogenesis and Ovariectomized Osteoporosis
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  4. Tumor necrosis factor receptor-associated factor 6 (TRAF6) inhibition modulates bone loss and matrix metalloproteinase expression levels in collagen-induced rheumatoid arthritis rat
    Jiangtao Guo, Xuqing Cao, Xiaoli Ma, Chunfang Hao, Lili Wu, Mingzhu Zhang, Yashan Yang, Jingtian Zhao, Kunting Chen, Zhe Yin · 2020 · Annals of Palliative Medicine
  5. Synthesis and evaluation of 2-NMPA derivatives as potential agents for prevention of osteoporosis in vitro and in vivo
    Zhihao Chen, Devaneyan Joseph, Mina Ding, Swapnil Pandurang Bhujbal, Robin Prakash Sirvin Rajan, Eunae Kim, Sang-Wook Park, Sunwoo Lee, Tae‐Hoon Lee · 2023 · European Journal of Medicinal Chemistry
  6. Extracellular Signal-Regulated Kinases Play Essential but Contrasting Roles in Osteoclast Differentiation
    Chaekyun Kim · 2023 · International Journal of Molecular Sciences
  7. Sequestosome 1/p62: a multi-domain protein with multi-faceted functions
    Xiaoyan Liu, József Gál, Haining Zhu · 2012 · Frontiers in Biology
  8. Ubiquitin specific peptidase 13 protects against inflammation-associated joint injury in collagen-induced rheumatoid arthritis mice by targeting TRAF6
    Haili Wang, Xinyi Sun, Kai Cui, Yan Wang, Yuman Sun · 2025 · International Immunopharmacology
  9. Why are the phenotypes of TRAF6 knock-in and TRAF6 knock-out mice so different?
    Tsvetana Petrova, Kyle Bennett, Sambit K. Nanda, Sam Strickson, Cheryl L. Scudamore, Alan R. Prescott, Philip Cohen · 2022 · PLoS ONE
  10. Caffeic Acid Inhibited Receptor Activator of Nuclear Factor kappaB Ligand (RANKL)-Tumor Necrosis Factor (TNF) alpha-TNF Receptor Associated Factor (TRAF) 6 induced Osteoclastogenesis Pathway
    Ferry Sandra, Toshio Kukita, Tatsushi Muta, Tadahiko Iijima · 2013 · The Indonesian Biomedical Journal
  11. A ubiquitin-specific, proximity-based labeling approach for the identification of ubiquitin ligase substrates
    Urbi Mukhopadyay, Sophie Levantovsky, Sarah Gharbi, Frank Stein, Christian Behrends, Sagar Bhogaraju · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  12. DYSREGULATION OF BONE METABOLISM DURING TYPE 2 DIABETES MELLITUS: ROLE OF TOLL-LIKE RECEPTOR-4 AND AUTOPHAGY
    Elizabeth Rendina-Ruedy · 2015 · SHAREOK (University of Oklahoma; Oklahoma State University; Central Oklahoma University)
  13. The Expression Levels of Transforming Growth Factor β1 and Tumor Necrosis Factor Receptor Associated Factor 6 in Allergic Rhinitis Patients and Their Potential Relationship with Epithelial - Mesenchymal Transition: A Pilot Prospective Observational Study
    Kai Wang, Gao Qin, Yelong Bai, Rong Yu, Qing Luo · 2024 · Journal of Asthma and Allergy
  14. Spica Prunella extract inhibits phosphorylation of JNK, ERK and IκBα signals during osteoclastogenesis
    Wan‐Kyu Ko, Jun-Young Cho, Ho‐Jin Moon, Min‐Seo Jung, Na-Rae Yang, Su-Jeong Heo, Sun Ha Kim, Jin‐Moo Lee, Yu‐Shik Hwang, Hojae Bae et al. · 2013 · Food Science and Biotechnology
  15. Osteoclast Signal Transduction Pathways: The RANKL/RANK System
    Zhenqiang Yao, Brendan F. Boyce · 2019 · Elsevier eBooks
  16. Targeting TRAF6 for Cancer Therapeutical Development
    John Kenneth Morrow · 2012 · Digital Commons-TMC (Texas Medical Center)
  17. Signaling mechanisms in regenerative myogenesis.
    Sajedah M. Hindi · 2014
  18. IDENTIFICATION OF SUMOYLATED PROTEINS AND INVESTIGATION OF PROTEIN UBIQUITINATION IN THE NF-κB PATHWAY
    Xiaoyan Liu · 2012 · UKnowledge (University of Kentucky)
  19. TRAF6 signaling in skeletal muscle atrophy and regeneration
    Pradyut K. Paul · 2011
  20. The Effects of Pueraria lobata on Osteoclast Differentiation and Bone Resorption
    Jong Min Baek, Kang Hugh Yoon, Sung‐Jun Ahn, Sun‐Hyang Park, Yoon‐Hee Cheon, Ju‐Young Kim, Jaemin Oh · 2014 · Korean Journal of Physical Anthropology
  21. Extrapancreatic actions of incretin-based therapies on bone in diabetes mellitus
    Sity Aishah Mansur · 2015 · UTHM Institutional Repository (Universiti Tun Hussein Onn Malaysia)
  22. Receptor Activator of NF-κB (RANK) Signaling
    Hiroshi Takayanagi · 2008 · Elsevier eBooks
  23. Atrophie, croissance et fonction musculaire : l'impact des leucocytes et de la triade RANK/RANKL/OPG
    Nicolas A. Dumont · 2013 · Corpus Université Laval (Université Laval)
  24. Role of NFκB in Bone Remodeling in Health and Cancer
    Aymen I. Idris · 2019 · Elsevier eBooks
  25. Silencing Itch in human PBMCs promotes differentiation of monocytes into osteoclasts
    Oliver J. Read, David James Harrison · 2022 · Research Square
  26. Silencing Itch in human peripheral blood monocytes promotes their differentiation into osteoclasts
    Oliver J. Read, David James Harrison · 2022 · Molecular Biology Reports
  27. Regulation of NF-κB Signaling by Regulatory Ubiquitination: Specific Pathways and A20
    Arnab De · 2015 · Springer theses
  28. Ekspresi BMP2 dan TRAF6 pada Jaringan Periodontal setelah Pemberian Ekstrak Kopi Robusta selama Pergerakan Gigi Ortodonti
    Herniyati Herniyati, Leliana Sandra Deviade Putri, Hestieyonini Hadnyanawati, Happy Harmono · 2023 · Pustaka Kesehatan
  29. Inhibitory Effects of Polygonati Odorati Rhizoma on Osteoclast Differentiation and Bone Resorption
    Byung Duk Joo, Won Jeong Shin, Sejeong Kim, Eun Ji Kim, Seo Yeon Park, Hyun Jun Lee, Hyuk‐Sang Jung, Eun‐Young Kim, Youngjoo Sohn · 2025 · Korean Journal of Acupuncture
  30. Regulation of NFATc3 stability by SUMO and E3 ubiquitin-ligases Trim39 and Trim17
    Meenakshi Basu-Shrivastava · 2020 · theses.fr (ABES)
  31. Strontium-substituted hydroxyapatite nanoparticles as dual-function regulators of osteoblast mineralization and RANKL-induced osteoclastogenesis
    Shiao‐Wen Tsai, Li Cheng, Shu-ting Lee, Pai‐An Hwang, Fu‐Yin Hsu · 2026 · Journal of Materials Science Materials in Medicine
  32. Quantitative Modeling of TLR Signaling Reveals Missing Negative Feedback Guiding Identification of TANK-IKKε Checkpoint
    Nathan P. Manes, Fengkai Zhang, Bin Lin, Jing Sun, Sergio A. Hassan, Anthony A. Armstrong, Yuting Shao, Jessica M. Calzola, Pauline R. Kaplan-Stafford, Rachel A. Gottschalk et al. · 2026 · SSRN Electronic Journal
  33. A peroxiredoxin 1–reactive oxygen species feedback loop modulates nuclear factor kappa B activity in osteoclastogenesis
    Hyerim Lee, Sheunghun Lee, You-Jee Jang, Kyubin Lee, Seon Young Hwang, Goo Taeg Oh, Jae-Il Park, Sun-Ju Yi, Kyunghwan Kim · 2026 · Molecular Biomedicine
  34. Small-molecule disruption of the TRAF6–Ubc13 protein–protein interaction: targeting noncanonical ubiquitin signaling in inflammation and cancer
    Saleh Alkhedhairi · 2026 · Biochemical Pharmacology