TRAF6 ubiquitin ligase is essential for RANKL signaling and osteoclast differentiation
Lamothe, Betty, Webster, William K., Gopinathan, Ambily, Besse, Arnaud, Campos, Alejandro D., Darnay, Bryant G.·2007·Biochemical and Biophysical Research Communications
Cited by (134)
Items 101–134 of 134
- Tangeretin suppresses RANKL-induced osteoclastogenesis and alleviates postmenopausal osteoporosis by inhibiting Notch signalingTengfei Wu, Fang Wang, Changqing Ai, Li Li, Fan Wu · 2025 · Regenerative Therapy
- Anti-inflammatory, but not osteoprotective, effect of the TRAF6/CD40 inhibitor 6877002 in rodent models of local and systemic osteolysisSilvia Marino, Nicole Hannemann, Ryan T. Bishop, F. Zeng, Giovana Carrasco, Sandrine Meurisse, Boya Li, Antonia Sophocleous, Anna Sparatore, Tobias Bäuerle et al. · 2021 · Biochemical Pharmacology
- Morusin Inhibits RANKL-induced Osteoclastogenesis and Ovariectomized OsteoporosisCong Guo Jin, Jiewen Zheng, Qichang Yang, Yewei Jia, Haibo Li, Xuewen Liu, Yangjun Xu, Zhuolin Chen, Lei He · 2023 · Combinatorial Chemistry & High Throughput Screening
- Tumor necrosis factor receptor-associated factor 6 (TRAF6) inhibition modulates bone loss and matrix metalloproteinase expression levels in collagen-induced rheumatoid arthritis ratJiangtao Guo, Xuqing Cao, Xiaoli Ma, Chunfang Hao, Lili Wu, Mingzhu Zhang, Yashan Yang, Jingtian Zhao, Kunting Chen, Zhe Yin · 2020 · Annals of Palliative Medicine
- Synthesis and evaluation of 2-NMPA derivatives as potential agents for prevention of osteoporosis in vitro and in vivoZhihao Chen, Devaneyan Joseph, Mina Ding, Swapnil Pandurang Bhujbal, Robin Prakash Sirvin Rajan, Eunae Kim, Sang-Wook Park, Sunwoo Lee, Tae‐Hoon Lee · 2023 · European Journal of Medicinal Chemistry
- Extracellular Signal-Regulated Kinases Play Essential but Contrasting Roles in Osteoclast DifferentiationChaekyun Kim · 2023 · International Journal of Molecular Sciences
- Sequestosome 1/p62: a multi-domain protein with multi-faceted functionsXiaoyan Liu, József Gál, Haining Zhu · 2012 · Frontiers in Biology
- Ubiquitin specific peptidase 13 protects against inflammation-associated joint injury in collagen-induced rheumatoid arthritis mice by targeting TRAF6Haili Wang, Xinyi Sun, Kai Cui, Yan Wang, Yuman Sun · 2025 · International Immunopharmacology
- Why are the phenotypes of TRAF6 knock-in and TRAF6 knock-out mice so different?Tsvetana Petrova, Kyle Bennett, Sambit K. Nanda, Sam Strickson, Cheryl L. Scudamore, Alan R. Prescott, Philip Cohen · 2022 · PLoS ONE
- Caffeic Acid Inhibited Receptor Activator of Nuclear Factor kappaB Ligand (RANKL)-Tumor Necrosis Factor (TNF) alpha-TNF Receptor Associated Factor (TRAF) 6 induced Osteoclastogenesis PathwayFerry Sandra, Toshio Kukita, Tatsushi Muta, Tadahiko Iijima · 2013 · The Indonesian Biomedical Journal
- A ubiquitin-specific, proximity-based labeling approach for the identification of ubiquitin ligase substratesUrbi Mukhopadyay, Sophie Levantovsky, Sarah Gharbi, Frank Stein, Christian Behrends, Sagar Bhogaraju · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
- DYSREGULATION OF BONE METABOLISM DURING TYPE 2 DIABETES MELLITUS: ROLE OF TOLL-LIKE RECEPTOR-4 AND AUTOPHAGYElizabeth Rendina-Ruedy · 2015 · SHAREOK (University of Oklahoma; Oklahoma State University; Central Oklahoma University)
- The Expression Levels of Transforming Growth Factor β1 and Tumor Necrosis Factor Receptor Associated Factor 6 in Allergic Rhinitis Patients and Their Potential Relationship with Epithelial - Mesenchymal Transition: A Pilot Prospective Observational StudyKai Wang, Gao Qin, Yelong Bai, Rong Yu, Qing Luo · 2024 · Journal of Asthma and Allergy
- Spica Prunella extract inhibits phosphorylation of JNK, ERK and IκBα signals during osteoclastogenesisWan‐Kyu Ko, Jun-Young Cho, Ho‐Jin Moon, Min‐Seo Jung, Na-Rae Yang, Su-Jeong Heo, Sun Ha Kim, Jin‐Moo Lee, Yu‐Shik Hwang, Hojae Bae et al. · 2013 · Food Science and Biotechnology
- Osteoclast Signal Transduction Pathways: The RANKL/RANK SystemZhenqiang Yao, Brendan F. Boyce · 2019 · Elsevier eBooks
- Targeting TRAF6 for Cancer Therapeutical DevelopmentJohn Kenneth Morrow · 2012 · Digital Commons-TMC (Texas Medical Center)
- Signaling mechanisms in regenerative myogenesis.Sajedah M. Hindi · 2014
- IDENTIFICATION OF SUMOYLATED PROTEINS AND INVESTIGATION OF PROTEIN UBIQUITINATION IN THE NF-κB PATHWAYXiaoyan Liu · 2012 · UKnowledge (University of Kentucky)
- TRAF6 signaling in skeletal muscle atrophy and regenerationPradyut K. Paul · 2011
- The Effects of Pueraria lobata on Osteoclast Differentiation and Bone ResorptionJong Min Baek, Kang Hugh Yoon, Sung‐Jun Ahn, Sun‐Hyang Park, Yoon‐Hee Cheon, Ju‐Young Kim, Jaemin Oh · 2014 · Korean Journal of Physical Anthropology
- Extrapancreatic actions of incretin-based therapies on bone in diabetes mellitusSity Aishah Mansur · 2015 · UTHM Institutional Repository (Universiti Tun Hussein Onn Malaysia)
- Receptor Activator of NF-κB (RANK) SignalingHiroshi Takayanagi · 2008 · Elsevier eBooks
- Atrophie, croissance et fonction musculaire : l'impact des leucocytes et de la triade RANK/RANKL/OPGNicolas A. Dumont · 2013 · Corpus Université Laval (Université Laval)
- Role of NFκB in Bone Remodeling in Health and CancerAymen I. Idris · 2019 · Elsevier eBooks
- Silencing Itch in human PBMCs promotes differentiation of monocytes into osteoclastsOliver J. Read, David James Harrison · 2022 · Research Square
- Silencing Itch in human peripheral blood monocytes promotes their differentiation into osteoclastsOliver J. Read, David James Harrison · 2022 · Molecular Biology Reports
- Regulation of NF-κB Signaling by Regulatory Ubiquitination: Specific Pathways and A20Arnab De · 2015 · Springer theses
- Ekspresi BMP2 dan TRAF6 pada Jaringan Periodontal setelah Pemberian Ekstrak Kopi Robusta selama Pergerakan Gigi OrtodontiHerniyati Herniyati, Leliana Sandra Deviade Putri, Hestieyonini Hadnyanawati, Happy Harmono · 2023 · Pustaka Kesehatan
- Inhibitory Effects of Polygonati Odorati Rhizoma on Osteoclast Differentiation and Bone ResorptionByung Duk Joo, Won Jeong Shin, Sejeong Kim, Eun Ji Kim, Seo Yeon Park, Hyun Jun Lee, Hyuk‐Sang Jung, Eun‐Young Kim, Youngjoo Sohn · 2025 · Korean Journal of Acupuncture
- Regulation of NFATc3 stability by SUMO and E3 ubiquitin-ligases Trim39 and Trim17Meenakshi Basu-Shrivastava · 2020 · theses.fr (ABES)
- Strontium-substituted hydroxyapatite nanoparticles as dual-function regulators of osteoblast mineralization and RANKL-induced osteoclastogenesisShiao‐Wen Tsai, Li Cheng, Shu-ting Lee, Pai‐An Hwang, Fu‐Yin Hsu · 2026 · Journal of Materials Science Materials in Medicine
- Quantitative Modeling of TLR Signaling Reveals Missing Negative Feedback Guiding Identification of TANK-IKKε CheckpointNathan P. Manes, Fengkai Zhang, Bin Lin, Jing Sun, Sergio A. Hassan, Anthony A. Armstrong, Yuting Shao, Jessica M. Calzola, Pauline R. Kaplan-Stafford, Rachel A. Gottschalk et al. · 2026 · SSRN Electronic Journal
- A peroxiredoxin 1–reactive oxygen species feedback loop modulates nuclear factor kappa B activity in osteoclastogenesisHyerim Lee, Sheunghun Lee, You-Jee Jang, Kyubin Lee, Seon Young Hwang, Goo Taeg Oh, Jae-Il Park, Sun-Ju Yi, Kyunghwan Kim · 2026 · Molecular Biomedicine
- Small-molecule disruption of the TRAF6–Ubc13 protein–protein interaction: targeting noncanonical ubiquitin signaling in inflammation and cancerSaleh Alkhedhairi · 2026 · Biochemical Pharmacology