A mutation of Keap1 found in breast cancer impairs its ability to repress Nrf2 activity
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- The Nrf2 transcription factor contributes to resistance to cisplatin in bladder cancerAnnette L. Hayden, James Douglas, Matthew Sommerlad, Lawrence Peter Andrews, Katherine Gould, Syed A. Hussain, Gareth J. Thomas, Graham Packham, Simon J. Crabb · 2014 · Urologic Oncology Seminars and Original Investigations
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- Glucose-6-phosphate dehydrogenase and transketolase modulate breast cancer cell metabolic reprogramming and correlate with poor patient outcomeAdrián Benito, Ibrahim H. Polat, Verónique Noé, Carlos J. Ciudad, Silvia Marín, Marta Cascante · 2017 · Oncotarget
- Xenobiotic-Activated Receptors: From Transcription to Drug Metabolism to DiseaseQiang Ma · 2008 · Chemical Research in Toxicology
- Clinical Implications of KEAP1-NFE2L2 Mutations in NSCLCJessica A. Hellyer, Sukhmani Kaur Padda, Maximilian Diehn, Heather A. Wakelee · 2020 · Journal of Thoracic Oncology
- Post‐transcriptional regulation of Nrf2‐mRNA by the mRNA‐binding proteins HuR and AUF1Jesse R. Poganik, Marcus J. C. Long, Michael T. Disare, Xuyu Liu, Sung‐Hee Chang, Timothy Hla, Yimon Aye · 2019 · The FASEB Journal
- Correlation of Nrf2, HO-1, and MRP3 in Gallbladder Cancer and Their Relationships to Clinicopathologic Features and SurvivalJiansheng Wang, Mingxin Zhang, Lingmin Zhang, Hui Cai, Suna Zhou, Jia Zhang, Yang Wang · 2010 · Journal of Surgical Research
- Role of Nrf2 Signaling Cascade in Breast Cancer: Strategies and TreatmentHitesh Kumar, Rachna M. Kumar, Devanjali Bhattacharjee, Preethi Somanna, Vikas Kumar Jain · 2022 · Frontiers in Pharmacology
- Trigonelline inhibits Nrf2 via EGFR signalling pathway and augments efficacy of Cisplatin and Etoposide in NSCLC cellsChandrani Fouzder, Alpana Mukhuty, Sandip Mukherjee, Chandan Malick, Rakesh Kundu · 2020 · Toxicology in Vitro
- KEAP1-Dependent Synthetic Lethality Induced by AKT and TXNRD1 Inhibitors in Lung CancerBingbing Dai, Suk‐Young Yoo, Geoffrey A. Bartholomeusz, Ryan A. Graham, Mourad Majidi, Shaoyu Yan, Jieru Meng, Lin Ji, Kevin R. Coombes, John Dorrance Minna et al. · 2013 · Cancer Research
- Regulation of cell signaling pathways by dietary agents for cancer prevention and treatmentManoj Kumar Pandey, Subash C. Gupta, Ali Nabavizadeh, Bharat Bhushan Aggarwal · 2017 · Seminars in Cancer Biology
- xCT inhibition sensitizes tumors to γ-radiation via glutathione reductionLara Cobler, Hui Zhang, Poojan Suri, Catherine Park, Luika Timmerman · 2018 · Oncotarget
- Aggressive mammary carcinoma progression in Nrf2 knockout mice treated with 7,12-dimethylbenz[a]anthraceneLisa Becks, Misty Prince, Hannah C. Burson, Christopher Christophe, Mason Broadway, Ken Itoh, Masayuki P. Yamamoto, James Michael Mathis, Elysse A. Orchard, Runhua Shi et al. · 2010 · BMC Cancer
- Nrf2: bane or blessing in cancer?Mingjun Xiang, Akhileshwar Namani, ShiJun Wu, XiaoLi Wang · 2014 · Journal of Cancer Research and Clinical Oncology
- The Role of Nrf2 in Migration and Invasion of Human Glioma Cell U251Hao Pan, Handong Wang, Lin Zhu, Lei Mao, Liang Qiao, Xingfen Su · 2011 · World Neurosurgery
- The see-saw of Keap1-Nrf2 pathway in cancerPoorti Pandey, Alok Kumar Singh, Mritunjai Singh, Mallika Tewari, Hari Shankar Shukla, Indrajeet Singh Gambhir · 2017 · Critical Reviews in Oncology/Hematology
- Functional Aspects of Redox Control During NeuroinflammationSergio Rosales‐Corral, Russel Joseph Reiter, Dun‐Xian Tan, Genaro G. Ortiz, Gabriela del Carmen López-Armas · 2009 · Antioxidants and Redox Signaling
- Non-enzymatic post-translational protein modifications and proteostasis network deregulation in carcinogenesisIoannis P. Trougakos, Fabiola Sesti, Eleni N. Tsakiri, Vassilis G. Gorgoulis · 2013 · Journal of Proteomics
- Epigenetic versus Genetic Deregulation of the KEAP1/NRF2 Axis in Solid Tumors: Focus on Methylation and Noncoding RNAsFederico Pio Fabrizio, Angelo Sparaneo, Domenico Trombetta, Lucia Anna Muscarella · 2018 · Oxidative Medicine and Cellular Longevity
- Role of Reductive versus Oxidative Stress in Tumor Progression and Anticancer Drug ResistanceKyung‐Soo Chun, Do‐Hee Kim, Young‐Joon Surh · 2021 · Cells
- A possible gene silencing mechanism: Hypermethylation of the Keap1 promoter abrogates binding of the transcription factor Sp1 in lung cancer cellsDuo Guo, Bo Wu, Jihong Yan, Xiaoshuang Li, Haimei Sun, Deshan Zhou · 2012 · Biochemical and Biophysical Research Communications
- Nrf2 Signaling in Renal Cell Carcinoma: A Potential Candidate for the Development of Novel Therapeutic StrategiesValentina Schiavoni, Monica Emanuelli, Giulio Milanese, Andrea Benedetto Galosi, Veronica Pompei, Eleonora Salvolini, Roberto Campagna · 2024 · International Journal of Molecular Sciences
- Effects of diclofenac on the expression of Nrf2 and its downstream target genes in mosquito fish (Gambusia affinis)Shuang Bao, Xiangping Nie, Ruikang Ou, Chao Wang, Peijia Ku, Kaibin Li · 2017 · Aquatic Toxicology
- Inhibition of the NRF2/KEAP1 Axis: A Promising Therapeutic Strategy to Alter Redox Balance of Cancer CellsEmiliano Panieri, Luciano Saso · 2021 · Antioxidants and Redox Signaling
- Nrf2 transcriptional derepression from Keap1 by dietary polyphenolsHenry K. Bayele, Edward S. Debnam, Surjit Kaila Srai · 2015 · Biochemical and Biophysical Research Communications
- NRF2 inhibition represses ErbB2 signaling in ovarian carcinoma cells: Implications for tumor growth retardation and docetaxel sensitivityManandhar, Sarala, Choi, Bo-hyun, Jung, Kyeong-Ah, Ryoo, In-geun, Song, Mingu, Kang, Su Jin, Choi, Han-Gon, Kim, Jung-Ae, Park, Pil-Hoon, Kwak, Mi-Kyoung · 2012 · Free Radical Biology and Medicine
- Significance of NRF2 in physiological and pathological conditions an comprehensive reviewMichalina Kryszczuk, Oksana Kowalczuk · 2022 · Archives of Biochemistry and Biophysics
- Knockdown of NF-E2-related factor 2 inhibits the proliferation and growth of U251MG human glioma cells in a mouse xenograft modelXiangjun Ji, SUI-HUA CHEN, Lin Zhu, Hao Pan, Yuan Zhou, Wei Li, Wanchun You, Chao-Chao Gao, Jianhong Zhu, Kuan Jiang et al. · 2013 · Oncology Reports
- Implications of aging and the endoplasmic reticulum unfolded protein response on the molecular modality of breast cancerRinki Minakshi, Safikur Rahman, Arif Tasleem Jan, Archana Ayyagari, Jihoe Kim · 2017 · Experimental & Molecular Medicine
- Anticancer Drug Metabolism: Chemotherapy Resistance and New Therapeutic ApproachesHanane Akhdar, Claire Legendre, Caroline Aninat, Fabrice More · 2012 · InTech eBooks
- Multifaceted Roles of the KEAP1–NRF2 System in Cancer and Inflammatory Disease MilieuHarit Panda, Huaichun Wen, Mikiko Suzuki, Masayuki P. Yamamoto · 2022 · Antioxidants
- The ‘N-factors’ in pancreatic cancer: functional relevance of NF-κB, NFAT and Nrf2 in pancreatic cancerAlexander Arlt, H. Schäfer, Holger Kalthoff · 2012 · Oncogenesis
- Frequent Tumor Burden Monitoring of Esophageal Squamous Cell Carcinoma With Circulating Tumor DNA Using Individually Designed Digital Polymerase Chain ReactionTakeshi Iwaya, Fumitaka Endo, Mizunori Yaegashi, Noriyuki Sasaki, Ryosuke Fujisawa, H. Hiraki, Y. Akiyama, A. Sasaki, Y. Suzuki, M. Masuda et al. · 2020 · Gastroenterology
- Hypermethylation of the Keap1 gene inactivates its function, promotes Nrf2 nuclear accumulation, and is involved in arsenite-induced human keratinocyte transformationDapeng Wang, Yuan Ma, Xu Yang, Xiguo Xu, Yingying Zhao, Zhen Hua Zhu, Xiaojuan Wang, Hanyi Deng, Chunchun Li, Fenfang Gao et al. · 2015 · Free Radical Biology and Medicine
- Resistance of neuroblastoma GI-ME-N cell line to glutathione depletion involves Nrf2 and heme oxygenase-1Anna Lisa Furfaro, José Raúl Zumba Macay, Barbara Marengo, Mariapaola Nitti, Alessia Parodi, Daniela Fenoglio, Umberto Maria Marinari, Maria Adelaide Pronzato, Cinzia Domenicotti, Nicola Traverso · 2011 · Free Radical Biology and Medicine
- Dual role of heme iron in cancer; promotor of carcinogenesis and an inducer of tumour suppressionSujani Madhurika Kodagoda Gamage, Katherine Ting‐Wei Lee, Lakal Dissabandara, Alfred King-yin Lam, Vinod Gopalan · 2021 · Experimental and Molecular Pathology
- Oncogenic transformation of mesenchymal stem cells decreases Nrf2 expression favoring in vivo tumor growth and poorer survivalJuan Manuel Funes, Stephen R Henderson, Rachel Kaufman, James M. Flanagan, Mathew P. Robson, Barbara R. Pedley, Salvador Moncada, Chris Boshoff · 2014 · Molecular Cancer
- Promoter demethylation of nuclear factor-erythroid 2-related factor 2 gene in drug-resistant colon cancer cellsXiaoqian Zhao, Yifei Zhang, YI-FANG XIA, Zhongmei Zhou, Ying-Qing Cao · 2015 · Oncology Letters
- RETRACTED ARTICLE: Downregulation of RKIP promotes radioresistance of nasopharyngeal carcinoma by activating NRF2/NQO1 axis via downregulating miR-450b-5pWei Huang, Guang-Qing Shi, Zhong Yong, Jian Li, Juan Qiu, Yan Wei Cao, Yongfeng Zhao, Yuan Li · 2020 · Cell Death and Disease · Retracted
- β-Sitosterol targets ASS1 for Nrf2 ubiquitin-dependent degradation, inducing ROS-mediated apoptosis via the PTEN/PI3K/AKT signaling pathway in ovarian cancerHaoyu Wang, Jingchun Liu, Zihui Zhang, Jiaxin Peng, Zhi Wang, Lian Yang, Xinqi Wang, Siyuan Hu, Hong Li · 2024 · Free Radical Biology and Medicine
- Effects of different extracts of curcumin on TPC1 papillary thyroid cancer cell lineAngelica Perna, Antonio De Luca, Laura Adelfi, Tammaro Pasquale, Bruno Varriale, Teresa Esposito · 2018 · BMC Complementary and Alternative Medicine
- The current status and future prospects for therapeutic targeting of KEAP1-NRF2 and β-TrCP-NRF2 interactions in cancer chemoresistanceRohini Srivastava, Raquel Fernández-Ginés, José Antonio Encinar, Antonio Cuadrado, Geoffrey Wells · 2022 · Free Radical Biology and Medicine
- ERK and PI3K signaling cascades induce Nrf2 activation and regulate cell viability partly through Nrf2 in human glioblastoma cellsZixiang Cong, Handong Wang, Jiawei Wang, Yuan Zhou, Hao Pan, Ding-Ding Zhang, Lin Zhu · 2013 · Oncology Reports
- Genetic inactivation of Nrf2 prevents clonal expansion of initiated cells in a nutritional model of rat hepatocarcinogenesisClaudia Orrù, Marta Szydlowska, Keiko Taguchi, Patrizia Zavattari, Andrea Perra, Masayuki P. Yamamoto, Amedeo Columbano · 2018 · Journal of Hepatology
- Dithiolethiones: A Privileged Pharmacophore for Anticancer Therapy and ChemopreventionMohd. Imran Ansari, Mohd M. Khan, Mohammad Saquib, Shahnaaz Khatoon, Mohd Kamil Hussain · 2018 · Future Medicinal Chemistry
- The nuclear factor erythroid 2-related factor 2/p53 axis in breast cancerHadi Fakheri, Mir Amirhossein Sajadi, Ahmad Afrashteh, Wenbiao Ma, Lei Xia, Mohammad Valilo · 2023 · Biochemia Medica
- Rexinoid inhibits Nrf2-mediated transcription through retinoid X receptor alphaJiaguo Wu, Hongyan Wang, Xiuwen Tang · 2014 · Biochemical and Biophysical Research Communications
- Unique Pattern of Component Gene Disruption in the NRF2 Inhibitor KEAP1/CUL3/RBX1 E3-Ubiquitin Ligase Complex in Serous Ovarian CancerVictor D. Martínez, Emily A. Vucic, Kelsie L. Thu, Larissa A. Pikor, Roland Hubaux, Wan L. Lam · 2014 · BioMed Research International
- Potential Protective and Therapeutic Roles of the Nrf2 Pathway in Ocular Diseases: An UpdateMing-xuan Wang, Jing Zhao, Hong Zhang, Ke Li, Lingzhi Niu, Yuanping Wang, Yajuan Zheng · 2020 · Oxidative Medicine and Cellular Longevity
- Importance of the Keap1-Nrf2 pathway in NSCLC: Is it a possible biomarker? (Review)Raúl Barrera Rodríguez · 2018 · Biomedical Reports
- Soft Cysteine Signaling Network: The Functional Significance of Cysteine in Protein Function and the Soft Acids/Bases Thiol Chemistry That Facilitates Cysteine ModificationRyan S. Wible, Thomas R. Sutter · 2017 · Chemical Research in Toxicology
- Cancer chemoprevention via activation of proteostatic modulesAimilia D. Sklirou, Eleni‐Dimitra Papanagnou, Nikolas Fokialakis, Ioannis P. Trougakos · 2017 · Cancer Letters
- Nrf2 expression in endometrial serous carcinomas and its precancers.Ning Chen, Xiaofang Yi, Nisreen Abushahin, Shujie Pang, Donna Zhang, Beihua Kong, Wenxin Zheng · 2010 · PubMed Central
- 2-Deoxy-D-glucose and 6-aminonicotinamide-mediated Nrf2 down regulation leads to radiosensitization of malignant cells via abrogation of GSH-mediated defensePradeep Sharma, Rajeev Kumar Varshney · 2012 · Free Radical Research
- Methylation Density Pattern of KEAP1 Gene in Lung Cancer Cell Lines Detected by Quantitative Methylation Specific PCR and PyrosequencingFederico Pio Fabrizio, Angelo Sparaneo, Flavia Centra, Domenico Trombetta, Clelia Tiziana Storlazzi, Paolo Graziano, Evaristo Maiello, Vito Michele Fazio, Lucia Anna Muscarella · 2019 · International Journal of Molecular Sciences
- Correlation of Nrf2 and HIF-1α in glioblastoma and their relationships to clinicopathologic features and survivalXiangjun Ji, Handong Wang, Jianhong Zhu, Yong Tang, Yuan Zhou, Lin Zhu, Chao-Chao Gao, Wei Li, Wanchun You, Bo Yu et al. · 2013 · Neurological Research
- Mitochondrial bioenergetics and drug-induced toxicity in a panel of mouse embryonic fibroblasts with mitochondrial DNA single nucleotide polymorphismsCláudia V. Pereira, Paulo Jorge Oliveira, Yvonne Will, Sashi Nadanaciva · 2012 · Toxicology and Applied Pharmacology
- Nrf2 expression is associated with poor outcome in osteosarcomaJae Young Park, Youn Wha Kim, Yong-Koo Park · 2012 · Pathology
- Regulation of Cell Proliferation and Nrf2-Mediated Antioxidant Defense: Conservation of Keap1 Cysteines and Nrf2 Binding Site in the Context of the Evolution of KLHL FamilyGregory A. Shilovsky, Daria V. Dibrova · 2023 · Life
- NRF2 level is negatively correlated with TGF-β1-induced lung cancer motility and migration via NOX4-ROS signalingDa-Young Ryu, Jinhee Lee, Mi‐Kyoung Kwak · 2020 · Archives of Pharmacal Research
- NRF2: Master regulator of cellular homeostasis and therapeutic vulnerability in cancerWei-Tai Chen, Nicholas W. McKee, Damaris Kuhnell, Matthew B. Dodson · 2026 · Redox Biology
- Mechanisms Underlying Chemopreventive Effects of Flavonoids via Multiple Signaling Nodes within Nrf2-ARE and AhR-XRE Gene Regulatory NetworksHan Xiao, Feng-Lin Lu, Derek Stewart, Yiguo Zhang · 2013 · Current Chemical Biology
- Cullin-3 protein expression levels correlate with breast cancer progressionKelly K. Haagenson, Larry R. Tait, Juan Wang, Malathy P.V. Shekhar, Lisa Polin, Wei Chen, Gen Sheng Wu · 2012 · Cancer Biology & Therapy
- Is redox signaling a feasible target for overcoming multidrug resistance in cancer chemotherapy?Manuela Polimeni, Elena Gazzano · 2014 · Frontiers in Pharmacology
- Effect of stable inhibition of NRF2 on doxorubicin sensitivity in human ovarian carcinoma OV90 cellsSarala Manandhar, Sangwhan Lee, Mi‐Kyoung Kwak · 2010 · Archives of Pharmacal Research
- Oncogenic mutations in KEAP1 disturbing inhibitory Nrf2‐Keap1 interaction: Activation of antioxidative pathway in papillary thyroid carcinomaDebora Lúcia Seguro Danilovic, Evandro Sobroza de Mello, Eliana Frazzatto, Alda Wakamatsu, Alexander A.L. Jorge, Ana O. Hoff, Suemi Marui · 2018 · Head & Neck
- Evaluation of the Epigenetic Demethylation of NRF2, a Master Transcription Factor for Antioxidant Enzymes, in Colorectal CancerZahra Taheri, Hamid Asadzadeh Aghdaei, Shiva Irani, Mohammad Hossein Modarressi, Zahra Noormohammadi · 2020 · Reports of Biochemistry and Molecular Biology
- AURKA emerges as a vulnerable target for KEAP1-deficient non-small cell lung cancer by activation of asparagine synthesisBing Deng, Fang Liu, Nana Chen, Xinhao Li, Jie Lei, Ning Chen, Jingjing Wu, Xuan Wang, Jie Lu, Mouxiang Fang et al. · 2024 · Cell Death and Disease
- Association of single-nucleotide polymorphisms of the KEAP1 gene with the risk of various human diseases and its functional impact using in silico analysisDhamodharan Umapathy, Ponjayanthi Balashanmugam, Dornadula Sireesh, Elango Bhakkiyalakshmi, Kunka Mohanram Ramkumar · 2018 · Pharmacological Research
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- Base excision repair accessory factors in senescence avoidance and resistance to treatmentsElise Vickridge, Camila Cristina Fraga Faraco, Alain Nepveu · 2022 · Cancer Drug Resistance
- Unique and overlapping roles of NRF2 and NRF1 in transcriptional regulationHiroki Sekine, Hozumi Motohashi · 2023 · Journal of Clinical Biochemistry and Nutrition
- Expression of Keap1 and Nrf2 in diffuse large B‑cell lymphoma and its clinical significanceXuemei Yi, Yajun Zhao, Xue Li, Jing Zhang, Yujie Qiao, Qianqian Jin, Hongling Li · 2018 · Experimental and Therapeutic Medicine
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- CACUL1/CAC1 Regulates the Antioxidant Response by Stabilizing Nrf2Yu Kigoshi, Tomomi Fukuda, Tomoyuki Endo, Nami Hayasaka, Shun‐ichiro Iemura, Tohru Natsume, Fuminori Tsuruta, Tomoki Chiba · 2015 · Scientific Reports
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- Expression of Nuclear Factor Erythroid 2 Protein in Malignant Cutaneous TumorsChang Yong Choi, Jin Young Kim, Seo Yeong Wee, Jang Hyun Lee, Doo Hyun Nam, Chul Han Kim, Moon Kyun Cho, Yoon Jin Lee, Hae Seon Nam, Sang-Han Lee et al. · 2014 · Archives of Plastic Surgery
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