Tau regulates the subcellular localization of calmodulin
Abstract
Lack of tau expression in neuronal cells results in a change in the expression of few genes. However, little is known about how tau regulates gene expression. Here we show that the presence of tau could alter the subcellular localization of calmodulin, a protein that could be located at the cytoplasm or in the nucleus. Nuclear calmodulin binds to co-transcription factors, regulating the expression of genes like calbindin. In this work, we have found that in neurons containing tau, a higher proportion of calmodulin is present in the cytoplasm compared with neurons lacking tau and that an increase in cytoplasmic calmodulin correlates with a higher expression of calbindin.
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Genetic deletion studies indicate that endogenous tau participates in neuronal processes including cytoskeletal regulation, mitochondrial dynamics, synaptic plasticity, network activity, and DNA/RNA stability.
“Genetic deletion studies indicate that endogenous tau participates in a range of neuronal processes, including cytoskeletal regulation, mitochondrial dynamics, synaptic plasticity, network activity [10–22], and stability of DNA and RNA stability [23].”
From Tau Ablation Rewires Brain Cell Programs in Health and Restores Function in Disease (2026) · cites this paper as [15]
The citation to this paper is attached to DNA and RNA stability. The Results (§3.1, p. 5) examine calmodulin localization in tau-deficient neurons, and the Discussion (§4, p. 5) addresses calbindin expression; neither addresses DNA or RNA stability. Searches for DNA/RNA stability and genomic integrity found no relevant passage in our copy. (LLM, conf=0.72)
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Research works printed but not linked: 4
- [8][8] D. Lai, M. Wan, J. Wu, P. Preston-Hurlburt, R. Kushwaha, T. Grundstrom, A.N. Imbalzano, T. Chi, Induction of TLR4-target genes entails calcium/calmodulindependent regulation of chromatin remodeling, Proc. Natl. Acad. Sci. USA 106 (2009) 1169-1174. -
- [10][10] P.G. Mermelstein, K. Deisseroth, N. Dasgupta, A.L. Isaksen, R.W. Tsien, Calmodulin priming: nuclear translocation of a calmodulin complex and the memory of prior neuronal activity, Proc. Natl. Acad. Sci. USA 98 (2001) 1534215347. -
- [13][13] M. Novak, R. Jakes, P.C. Edwards, C. Milstein, C.M. Wischik, Difference between the tau protein of Alzheimer paired helical filament core and normal tau revealed by epitope analysis of monoclonal antibodies 423 and 7.51, Proc. Natl. Acad. Sci. USA 88 (1991) 5837-5841. -
- [19][19] L. Serrano, J. de la Torre, R.B. Maccioni, J. Avila, Involvement of the carboxylterminal domain of tubulin in the regulation of its assembly, Proc. Natl. Acad. Sci. USA 81 (1984) 5989-5993.
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Tau Ablation Rewires Brain Cell Programs in Health and Restores Function in Disease
Chimal-Juárez, E., Patel, H., Jury-Garfe, N., Dabin, L. C., Vidal, R., Kim, J., & Lasagna-Reeves, C. A. (2026) · bioRxiv · doi:10.64898/2026.05.12.724684
- Authors
- Barreda, E. G. D., & Avila, J.
- Affiliations
- Consejo Superior de Investigaciones Científicas (ES)
- Venue
- Biochemical and Biophysical Research Communications
- Publisher
- Elsevier BV
- Published
- 2011-05
- Volume
- 408
- Issue
- 3
- Pages
- 500-504
- ISSN
- 0006-291X (ISSN-L)
- OpenAlex
- W2076842055
- Cited by
- 15
- References
- 0
- Citations by year
- 2026: 1 · 2021: 3 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 2 · 2016: 1 · 2015: 1 · 2013: 2 · 2012: 2
- FWCI
- 0.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochemical and Biophysical Research Communications (publishedVersion)
- PubMed (publishedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
- Funders
- Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas
- Comunidad de Madrid
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › S100 Proteins and Annexins
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Calpain Protease Function and Regulation
- Keywords
- tau protein, calmodulin, subcellular localization, calbindin, gene expression regulation, neurons
- MeSH terms
- Animals, Calmodulin, Cells, Cultured, Gene Expression Regulation, Hippocampus, Humans, Mice, Mutant Strains, Neurons, tau Proteins, Cell Line, Tumor, Mice, Calbindins, S100 Calcium Binding Protein G
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