K-Ras(G12D)-selective inhibitory peptides generated by random peptide T7 phage display technology

Sakamoto, Kotaro, Kamada, Yusuke, Sameshima, Tomoya, Yaguchi, Masahiro, Niida, Ayumu, Sasaki, Shigekazu, Miwa, Masanori, Ohkubo, Shoichi +4 more·2017·Biochemical and Biophysical Research Communications

Cited by (126)

Items 101–126 of 126

  1. Targeting der kleinen GTPasen über ihre regulatorischen Proteine
    Janine L. Gray, F. von Delft, Paul E. Brennan · 2019 · Angewandte Chemie
  2. Identifying peptides that specifically bind to MDA-MB-468 breast cancer cells*
    Xiaoli Dai, Qing Zhang, Huili Zhang, Hongtao Xu · 2019 · Oncology and Translational Medicine
  3. KRAS: The Art of Understanding a Complex Gene
    Walter V. Velasco, Marco A. Ramos-Castaneda, Michael J. Clowers, Shanshan Deng, Seyed Javad Moghaddam · 2020 · Elsevier eBooks
  4. Mechanistic Insight on Ras Inhibition Strategies in Cancer Therapy
    Jeiran Pashapour Anoosheh, Abolfazl Barzegar, Mohammad Saeid Hejazi, Nikoo Hasheminejad, Hamid Reza Heidari, Elnaz Mehdizadeh Aghdam · 2021 · Pharmaceutical Sciences
  5. Emerging Peptide Drug Modalities for Intracellular Target Space
    Tomi K. Sawyer · 2022 · AAPS advances in the pharmaceutical sciences series
  6. The dynamicity of mutant KRAS β2 strand modulates its downstream activation and predicts anticancer KRAS inhibition
    Jeiran Pashapour Anoosheh, Abolfazl Barzegar, Mohammad Saeid Hejazi, Elnaz Mehdizadeh Aghdam · 2022 · Life Sciences
  7. Development of the vasoactive intestinal peptide receptor 2 (VIPR2) antagonist peptide for the treatment of schizophrenia
    Yukio Ago, Satoshi Asano, Kotaro Sakamoto · 2023 · Folia Pharmacologica Japonica
  8. Targeting Rat Sarcoma Viral Oncogene Homolog for Treatment of Gastrointestinal Cancers
    Hannah Ruth Robinson, Sarah Lindsey Davis, Christopher Hanyoung Lieu · 2023 · Advances in Oncology
  9. A Review of the in Silico Design and Development Approaches of Ras-Specific Anticancer Therapeutics
    Parinaz Motiei, Hamid Reza Heidari, Mohammad Saeid Hejazi, Ommoleila Molavi, Elnaz Mehdizadeh Aghdam · 2023 · International Journal of Peptide Research and Therapeutics
  10. A Suite of Biochemical and Cell-Based Assays for the Characterization of KRAS Inhibitors and Degraders
    Medhanie Kidane, Rene M. Hoffman, Jennifer K. Wolfe-Demarco, Ting-Yu Huang, Chi-Ling Teng, Luis M. Gonzalez Lira, Jennifer Lin‐Jones, Gabriel Pallares, Jane E. Lamerdin, Nicole B. Servant et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  11. NMR structural studies of G-quadruplexes nucleic acids from KRAS and their interaction with ligands.
    Julien Marquevielle · 2019
  12. Mirror-image mRNA display uncovers isoform-selective D-peptide macrocycles targeting a cryptic KRAS pocket
    Matthew J. Mitcheltree, Nicole Boo, Nicolas C. Boyer, Zachary Z. Brown, Xiaomei Chai, Ruchia Duggal, Michael Garrigou, Robert P. Hayes, Jennifer M. Johnston, Hubert B. Josien et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  13. RAS and KRAS Inhibitors in Cancer Therapeutic Mechanisms and Resistance: Scoping Review with ☸SAIMSARA
    SAIMSARA · 2026 · SAIMSARA Journal
  14. Targeting the Undruggable: Deep Learning-Driven Design of Peptide Therapeutics in Cancer
    Ha Thi Ngoc Nguyen, Bao Hong Ngoc Le, Nhung Thi Hong Van, Trinh Thi Tuyet Tran, Tuan Minh Nguyen · 2026 · Pharmaceuticals
  15. Peptide-protein interactions in drug discovery
    Huazhang Ying, Yipin Lei, Yihai Luo, Jianyang Zeng, César de la Fuente‐Núñez · 2026 · Cell Biomaterials
  16. BindingDB Entry 50019814: Annual review of KRAS inhibitors in 2022.
    BindingDB · 2024 · UC San Diego
  17. BindingDB Entry 50016805: Accelerated Identification of Cell Active KRAS Inhibitory Macrocyclic Peptides using Mixture Libraries and Automated Ligand Identification System (ALIS) Technology.
    BindingDB · 2023 · UC San Diego
  18. BindingDB Entry 50014692: Discovery of a Bicyclic Peptidyl Pan-Ras Inhibitor.
    BindingDB · 2022 · UC San Diego
  19. BindingDB Entry 50015977: Cyclic Peptide Screening Methods for Preclinical Drug Discovery.
    BindingDB · 2023 · UC San Diego
  20. BindingDB Entry 50000202: Investigation of the structural requirements of K-Ras(G12D) selective inhibitory peptide KRpep-2d using alanine scans and cysteine bridging.
    BindingDB · 2019 · UC San Diego
  21. BindingDB Entry 50015318: Identification of MRTX1133, a Noncovalent, Potent, and Selective KRAS
    BindingDB · 2023 · UC San Diego
  22. BindingDB Entry 50023484: Peptide inhibitors targeting Ras and Ras-associated protein-protein interactions.
    BindingDB · 2026 · UC San Diego
  23. BindingDB Entry 50015546: Targeting a Novel KRAS Binding Site: Application of One-Component Stapling of Small (5-6-mer) Peptides.
    BindingDB · 2023 · UC San Diego
  24. BindingDB Entry 50000602: Crystal Structure of a Human K-Ras G12D Mutant in Complex with GDP and the Cyclic Inhibitory Peptide KRpep-2d.
    BindingDB · 2019 · UC San Diego
  25. BindingDB Entry 50012931: De-risking Drug Discovery of Intracellular Targeting Peptides: Screening Strategies to Eliminate False-Positive Hits.
    BindingDB · 2022 · UC San Diego
  26. BindingDB Entry 50021293: Cyclic Peptide Keap1-Nrf2 Protein-Protein Interaction Inhibitors: Design, Synthesis, and In Vivo Treatment of Acute Lung Injury.
    BindingDB · 2025 · UC San Diego