K-Ras(G12D)-selective inhibitory peptides generated by random peptide T7 phage display technology
Sakamoto, Kotaro, Kamada, Yusuke, Sameshima, Tomoya, Yaguchi, Masahiro, Niida, Ayumu, Sasaki, Shigekazu, Miwa, Masanori, Ohkubo, Shoichi +4 more·2017·Biochemical and Biophysical Research Communications
Cited by (126)
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- KRAS: The Art of Understanding a Complex GeneWalter V. Velasco, Marco A. Ramos-Castaneda, Michael J. Clowers, Shanshan Deng, Seyed Javad Moghaddam · 2020 · Elsevier eBooks
- Mechanistic Insight on Ras Inhibition Strategies in Cancer TherapyJeiran Pashapour Anoosheh, Abolfazl Barzegar, Mohammad Saeid Hejazi, Nikoo Hasheminejad, Hamid Reza Heidari, Elnaz Mehdizadeh Aghdam · 2021 · Pharmaceutical Sciences
- Emerging Peptide Drug Modalities for Intracellular Target SpaceTomi K. Sawyer · 2022 · AAPS advances in the pharmaceutical sciences series
- The dynamicity of mutant KRAS β2 strand modulates its downstream activation and predicts anticancer KRAS inhibitionJeiran Pashapour Anoosheh, Abolfazl Barzegar, Mohammad Saeid Hejazi, Elnaz Mehdizadeh Aghdam · 2022 · Life Sciences
- Development of the vasoactive intestinal peptide receptor 2 (VIPR2) antagonist peptide for the treatment of schizophreniaYukio Ago, Satoshi Asano, Kotaro Sakamoto · 2023 · Folia Pharmacologica Japonica
- Targeting Rat Sarcoma Viral Oncogene Homolog for Treatment of Gastrointestinal CancersHannah Ruth Robinson, Sarah Lindsey Davis, Christopher Hanyoung Lieu · 2023 · Advances in Oncology
- A Review of the in Silico Design and Development Approaches of Ras-Specific Anticancer TherapeuticsParinaz Motiei, Hamid Reza Heidari, Mohammad Saeid Hejazi, Ommoleila Molavi, Elnaz Mehdizadeh Aghdam · 2023 · International Journal of Peptide Research and Therapeutics
- A Suite of Biochemical and Cell-Based Assays for the Characterization of KRAS Inhibitors and DegradersMedhanie Kidane, Rene M. Hoffman, Jennifer K. Wolfe-Demarco, Ting-Yu Huang, Chi-Ling Teng, Luis M. Gonzalez Lira, Jennifer Lin‐Jones, Gabriel Pallares, Jane E. Lamerdin, Nicole B. Servant et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- NMR structural studies of G-quadruplexes nucleic acids from KRAS and their interaction with ligands.Julien Marquevielle · 2019
- Mirror-image mRNA display uncovers isoform-selective D-peptide macrocycles targeting a cryptic KRAS pocketMatthew J. Mitcheltree, Nicole Boo, Nicolas C. Boyer, Zachary Z. Brown, Xiaomei Chai, Ruchia Duggal, Michael Garrigou, Robert P. Hayes, Jennifer M. Johnston, Hubert B. Josien et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- RAS and KRAS Inhibitors in Cancer Therapeutic Mechanisms and Resistance: Scoping Review with ☸SAIMSARASAIMSARA · 2026 · SAIMSARA Journal
- Targeting the Undruggable: Deep Learning-Driven Design of Peptide Therapeutics in CancerHa Thi Ngoc Nguyen, Bao Hong Ngoc Le, Nhung Thi Hong Van, Trinh Thi Tuyet Tran, Tuan Minh Nguyen · 2026 · Pharmaceuticals
- Peptide-protein interactions in drug discoveryHuazhang Ying, Yipin Lei, Yihai Luo, Jianyang Zeng, César de la Fuente‐Núñez · 2026 · Cell Biomaterials
- BindingDB Entry 50019814: Annual review of KRAS inhibitors in 2022.BindingDB · 2024 · UC San Diego
- BindingDB Entry 50016805: Accelerated Identification of Cell Active KRAS Inhibitory Macrocyclic Peptides using Mixture Libraries and Automated Ligand Identification System (ALIS) Technology.BindingDB · 2023 · UC San Diego
- BindingDB Entry 50014692: Discovery of a Bicyclic Peptidyl Pan-Ras Inhibitor.BindingDB · 2022 · UC San Diego
- BindingDB Entry 50015977: Cyclic Peptide Screening Methods for Preclinical Drug Discovery.BindingDB · 2023 · UC San Diego
- BindingDB Entry 50000202: Investigation of the structural requirements of K-Ras(G12D) selective inhibitory peptide KRpep-2d using alanine scans and cysteine bridging.BindingDB · 2019 · UC San Diego
- BindingDB Entry 50015318: Identification of MRTX1133, a Noncovalent, Potent, and Selective KRASBindingDB · 2023 · UC San Diego
- BindingDB Entry 50023484: Peptide inhibitors targeting Ras and Ras-associated protein-protein interactions.BindingDB · 2026 · UC San Diego
- BindingDB Entry 50015546: Targeting a Novel KRAS Binding Site: Application of One-Component Stapling of Small (5-6-mer) Peptides.BindingDB · 2023 · UC San Diego
- BindingDB Entry 50000602: Crystal Structure of a Human K-Ras G12D Mutant in Complex with GDP and the Cyclic Inhibitory Peptide KRpep-2d.BindingDB · 2019 · UC San Diego
- BindingDB Entry 50012931: De-risking Drug Discovery of Intracellular Targeting Peptides: Screening Strategies to Eliminate False-Positive Hits.BindingDB · 2022 · UC San Diego
- BindingDB Entry 50021293: Cyclic Peptide Keap1-Nrf2 Protein-Protein Interaction Inhibitors: Design, Synthesis, and In Vivo Treatment of Acute Lung Injury.BindingDB · 2025 · UC San Diego