HMGCS2 promotes autophagic degradation of the amyloid-β precursor protein through ketone body-mediated mechanisms

Hu, Li-Tian; Zhu, Bing-Lin; Lai, Yu-Jie; Long, Yan; Zha, Jing-Si; Hu, Xiao-Tong; Zhang, John H.; Chen, Guo-Jun

doi:10.1016/j.bbrc.2017.03.069

HMGCS2 promotes autophagic degradation of the amyloid-β precursor protein through ketone body-mediated mechanisms

HMGCS2 (mitochondrial 3-hydroxy-3-methylglutaryl-COA synthase 2) is a control enzyme in ketogenesis. The mitochondrial localization and interaction with APP (β-amyloid precursor protein) suggest that HMGCS2 may play a role in the pathophysiology of AD (Alzheimer's disease). Here we report that ov…