Catechins Activate Muscle Stem Cells by Myf5 Induction and Stimulate Muscle Regeneration
Abstract
Muscle weakness is one of the most common symptoms in aged individuals and increases risk of mortality. Thus, maintenance of muscle mass is important for inhibiting aging. In this study, we investigated the effect of catechins, polyphenol compounds in green tea, on muscle regeneration. We found that (-)-epicatechin gallate (ECG) and (-)-epigallocatechin-3-gallate (EGCG) activate satellite cells by induction of Myf5 transcription factors. For satellite cell activation, Akt kinase was significantly induced after ECG treatment and ECG-induced satellite cell activation was blocked in the presence of Akt inhibitor. ECG also promotes myogenic differentiation through the induction of myogenic markers, including Myogenin and Muscle creatine kinase (MCK), in satellite and C2C12 myoblast cells. Finally, EGCG administration to mice significantly increased muscle fiber size for regeneration. Taken together, the results suggest that catechins stimulate muscle stem cell activation and differentiation for muscle regeneration.
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Epicatechin gallate promotes myogenic differentiation in C2C12 cells.
“Epicatechin gallate also promotes myogenic differentiation in C2C12 cells [90].”
From Nutraceuticals in the Prevention and Treatment of the Muscle Atrophy (2021) · cites this paper as [90]
Intraperitoneal administration of epicatechin gallate to C57BL/6 mice stimulates muscle satellite cell activation and differentiation, which is necessary for muscle regeneration.
“Intraperitoneally administration of epicatechin gallate to C57BL/6 mice stimulates muscle satellite cell activation and differentiation, which is necessary for muscle regeneration.”
From Nutraceuticals in the Prevention and Treatment of the Muscle Atrophy (2021) · cites this paper as [90]
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References 26 · Cited by 49
- Authors
- Kim, A. R., Kim, K. M., Byun, M. R., Hwang, J.-H., Park, J. I., Oh, H. T., Kim, H. K., Jeong, M. G., Hwang, E. S., & Hong, J.-H.
- Affiliations
- Korea University (KR)
- Ewha Womans University (KR)
- Corresponding author
- Hong, Jeong-Ho
- Venue
- Biochemical and Biophysical Research Communications
- Publisher
- Elsevier BV
- Published
- 2017-07
- Volume
- 489
- Issue
- 2
- Pages
- 142-148
- ISSN
- 0006-291X (ISSN-L)
- OpenAlex
- W2617853379
- Cited by
- 49
- References
- 26
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 3 · 2023: 6 · 2022: 6 · 2021: 9 · 2020: 8 · 2019: 5 · 2018: 2 · 2017: 1 · 2013: 1
- FWCI
- 1.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochemical and Biophysical Research Communications (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Korea University
- Ministry of Education (2014R1A2A2A01006547, 2015R1A5A1009024)
- National Research Foundation of Korea
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Pathology and Forensic Medicine › Tea Polyphenols and Effects
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Keywords
- catechins, epicatechin gallate, epigallocatechin gallate, green tea polyphenols, satellite cells, muscle stem cells, Myf5, Akt kinase, myogenesis, muscle regeneration, muscle aging, muscle fiber size, myoblasts
- MeSH terms
- Animals, Catechin, Cell Differentiation, Cells, Cultured, Dose-Response Relationship, Drug, Male, Mice, Inbred C57BL, Molecular Conformation, Muscles, Regeneration, Structure-Activity Relationship, Satellite Cells, Skeletal Muscle, Mice, Myogenic Regulatory Factor 5
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