Identification of an argpyrimidine-modified protein in human red blood cells from schizophrenic patients: A possible biomarker for diseases involving carbonyl stress
Abstract
Argpyrimidine (ARP) is an advanced glycation end product thought to be generated from a reaction between methylglyoxal and arginine residues in proteins. In this study, we observed marked accumulation of an approximately 56 kD protein, reactive to anti-ARP antibodies, in the red blood cells (RBCs) of some patients with refractory schizophrenia. This ARP-modified protein was purified from the blood of schizophrenic patients and identified as selenium binding protein 1 (SBP1) by LC-MS/MS. This is the first report of ARP-modified proteins accumulating in RBCs of patients with diseases involving carbonyl stress. We also observed high accumulation of ARP-modified SBP1 in the RBCs of patients with chronic kidney disease. Therefore, this modified protein may be a novel marker of carbonyl stress.
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Pentosidine levels in red blood cell lysates did not differ between schizophrenia patients and controls (n = 23 per group), measured by WB.
“| Schizophrenia | Red blood cell lysates | Control subjects vs. schizophrenia patients (n = 23 per group) | WB | No differences in pentosidine levels | [236] |”
From Protein oxidation - Formation mechanisms, detection and relevance as biomarkers in human diseases (2021) · cites this paper as [236]
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References 27 · Cited by 20
- Authors
- Ishida, Y. I., Kayama, T., Kibune, Y., Nishimoto, S., Koike, S., Suzuki, T., Horiuchi, Y., Miyashita, M., Itokawa, M., Arai, M., & Ogasawara, Y.
- Affiliations
- Meiji Pharmaceutical University (JP)
- Tokyo Metropolitan Institute of Medical Science (JP)
- Corresponding author
- Ogasawara, Y.
- Venue
- Biochemical and Biophysical Research Communications
- Publisher
- Elsevier BV
- Published
- 2017-11
- Volume
- 493
- Issue
- 1
- Pages
- 573-577
- ISSN
- 0006-291X (ISSN-L)
- OpenAlex
- W2750763701
- Cited by
- 20
- References
- 27
- Citations by year
- 2023: 4 · 2022: 3 · 2021: 5 · 2020: 3 · 2019: 3 · 2018: 2
- FWCI
- 1.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Biochemical and Biophysical Research Communications (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (16K08383, 17K15525)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer-related gene regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- argpyrimidine, advanced glycation end products, methylglyoxal, protein carbonylation, carbonyl stress, SELENBP1, erythrocytes, refractory schizophrenia, chronic kidney disease, biomarkers
- MeSH terms
- Erythrocytes, Female, Humans, Japan, Male, Ornithine, Pyrimidines, Schizophrenia, Sensitivity and Specificity, Reproducibility of Results, Biomarkers, Prevalence, Risk Assessment, Protein Carbonylation, Selenium-Binding Proteins
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