2.8-Å crystal structure of Escherichia coli YidC revealing all core regions, including flexible C2 loop

Tanaka, Yoshiki; Izumioka, Akiya; Abdul Hamid, Aisyah; Fujii, Akira; Haruyama, Takamitsu; Furukawa, Arata; Tsukazaki, Tomoya

doi:10.1016/j.bbrc.2018.09.043

2.8-Å crystal structure of Escherichia coli YidC revealing all core regions, including flexible C2 loop

YidC/Alb3/Oxa1 family proteins are involved in the insertion and assembly of membrane proteins. The core five transmembrane regions of YidC, which are conserved in the protein family, form a positively charged cavity open to the cytoplasmic side. The cavity plays an important role in membrane pro…