Neutralizing serum amyloid a protects against sinusoidal endothelial cell damage and platelet aggregation during acetaminophen-induced liver injury

You, Kai; Wang, Yan; Chen, Xiaoxia; Yang, Zhen; Chen, Yan; Tan, Shenglin; Tao, Jiawang; Getachew, Anteneh; Pan, Tingcai; Xu, Yingying; Zhuang, Yuanqi; Yang, Fan; Lin, Xianhua; Li, Yinxiong

doi:10.1016/j.bbrc.2022.11.079

Neutralizing serum amyloid a protects against sinusoidal endothelial cell damage and platelet aggregation during acetaminophen-induced liver injury

Serum amyloid A (SAA) is an acute response protein that mainly produced by hepatocytes, and it can promote endothelial dysfunction via a pro-inflammatory and pro-thrombotic effect in atherosclerosis and renal disease. Overdose of Acetaminophen (APAP) will cause hepatotoxicity accompany with hepat…