White adipose tissue dysfunction in obesity and aging
Open accessAbstract
Both obesity and aging are associated with the development of metabolic diseases such as type 2 diabetes and cardiovascular disease. Chronic low-grade inflammation of adipose tissue is one of the mechanisms implicated in the progression of these diseases. Obesity and aging trigger adipose tissue alterations that ultimately lead to a pro-inflammatory phenotype of the adipose tissue-resident immune cells. Obesity and aging also share other features such as a higher visceral vs. subcutaneous adipose tissue ratio and a decreased lifespan. Here, we review the common characteristics of obesity and aging and the alterations in white adipose tissue and resident immune cells. We focus on the adipose tissue metabolic derangements in obesity and aging such as inflammation and adipose tissue remodeling.
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This gradual aging-related reduction in SM mass contributes towards an overall decline in SM strength, function, and regenerative capacity, and is a key contributor to aging-related frailty.
“This gradual aging-related reduction in SM mass (trending towards a state of sarcopenia) contributes towards an overall decline in SM strength, function, and regenerative capacity, and is a key contributor to aging-related frailty with important implications for global health and economics [29,30,31,32].”
From Optimised Skeletal Muscle Mass as a Key Strategy for Obesity Management (2025) · cites this paper as [31]
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References 193 · Cited by 250
- Authors
- Reyes-Farias, M., Fos-Domenech, J., Serra, D., Herrero, L., & Sánchez-Infantes, D.
- Affiliations
- Instituto de Salud Carlos III (ES)
- Corresponding author
- Herrero, Laura
- Venue
- Biochemical Pharmacology
- Publisher
- Elsevier BV
- Published
- 2021-10
- Volume
- 192
- Pages
- 114723
- ISSN
- 0006-2952 (ISSN-L)
- OpenAlex
- W3190760415
- Cited by
- 250
- References
- 193
- Citations by year
- 2026: 49 · 2025: 57 · 2024: 77 · 2023: 38 · 2022: 26 · 2021: 3
- FWCI
- 5.55
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Biochemical Pharmacology (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) (submittedVersion, cc-by)
- Funders
- Ministerio de Economía y Competitividad (SAF2017-83813-C3-1-R)
- Instituto de Salud Carlos III (PI17/01455)
- European Regional Development Fund
- Ministerio de Asuntos Económicos y Transformación Digital
- Centro de Investigación Biomédica en Red-Fisiopatología de la Obesidad y Nutrición (CB06/03/0001)
- Generalitat de Catalunya (2017SGR278)
- Fundació la Marató de TV3 (201627-30)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- white adipose tissue, obesity, aging, adipose tissue inflammation, low-grade inflammation, visceral adipose tissue, subcutaneous adipose tissue, adipose tissue remodeling, type 2 diabetes, cardiovascular disease, lifespan
- MeSH terms
- Aging, Animals, Humans, Obesity, Intra-Abdominal Fat, Body Fat Distribution, Adipose Tissue, White, Adipocytes, White
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