Obstructive sleep apnea: role in the risk and severity of diabetes
Open accessAbstract
Obstructive sleep apnea (OSA) is a treatable sleep disorder that is pervasive among overweight and obese individuals. Current evidence supports a robust association between OSA and insulin resistance, glucose intolerance and the risk of type 2 diabetes, independent of obesity. Up to 83% of patients with type 2 diabetes suffer from unrecognized OSA and increasing severity of OSA is independently associated with poorer glucose control. Evidence from animal and human models that mimic OSA supports a potential causal role for OSA in altered glucose metabolism. Robust prospective and randomized clinical trials are still needed to test the hypothesis that effective treatment of OSA may prevent the development of type 2 diabetes and its complications, or reduce its severity. Type 2 diabetes is occurring at alarming rates worldwide and despite available treatment options, the economic and public health burden of this epidemic remains enormous. OSA might represent a novel, modifiable risk factor for the development of prediabetes and type 2 diabetes.
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Obstructive sleep apnea seems to be highly prevalent among patients with type 2 diabetes, with estimates ranging from 58 to 86%.
“Indeed, obstructive sleep apnea seems to be highly prevalent among patients with type 2 diabetes, with estimates ranging from 58 to 86% [20].”
From Association between sleep deficiency and cardiometabolic disease: implications for health disparities (2016) · cites this paper as [20]
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References 94 · Cited by 121
- Authors
- Pamidi, S., Aronsohn, R. S., & Tasali, E.
- Affiliations
- University of Chicago (US)
- Corresponding author
- Pamidi, Sushmita
- Venue
- Best Practice & Research Clinical Endocrinology & Metabolism
- Publisher
- Elsevier BV
- Published
- 2010-10
- Volume
- 24
- Issue
- 5
- Pages
- 703-715
- ISSN
- 1521-690X (ISSN-L)
- PMC
- PMC2994098
- OpenAlex
- W1967195443
- Cited by
- 121
- References
- 94
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 7 · 2023: 4 · 2022: 4 · 2021: 5 · 2020: 5 · 2019: 5 · 2018: 7 · 2017: 8 · 2016: 10 · 2015: 8 · 2014: 9 · 2013: 15 · 2012: 14
- FWCI
- 1.25
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Best Practice & Research Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (P01-AG11412., P01AG011412)
- National Heart, Lung, and Blood Institute (RC1HL100046, R01HL086459)
- National Center for Research Resources (P41RR013642)
- Topics
- Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- obstructive sleep apnea, type 2 diabetes, insulin resistance, impaired glucose tolerance, prediabetes, glucose metabolism, obesity, diabetes prevention, diabetes complications, economic burden of diabetes
- MeSH terms
- Animals, Diabetes Mellitus, Type 2, Glucose, Humans, Insulin Resistance, Prediabetic State, Risk Factors, Severity of Illness Index, Glucose Intolerance, Sleep Apnea, Obstructive
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