The DOI matches its Crossref record; 68 of the 70 references it cites were found in a registry or an index.
Screening for congenital hypothyroidism: A worldwide view of strategies
Abstract
Detection by newborn screening (NBS) and treatment of babies with congenital hypothyroidism (CH) has largely eliminated the intellectual disability caused by this disorder. Lowering of the screening TSH cutoff and changes in birth demographics have been associated with an approximate doubling of the incidence of CH, from 1:3500 to 1:1714. The additional cases detected by lowering of the TSH cutoff tend to have milder hypothyroidism, with imaging often demonstrating a eutopic, "gland in-situ", and some cases turn out to have transient CH. Based on our search for current screening programs, approximately 71 percent of babies worldwide are not born in an area with an established NBS program, despite the existence of screening for over five decades in developed countries. Thus, the majority of babies with CH worldwide are not detected and treated early, such that the economic burden of retardation owing to CH remains a significant public health challenge.
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In the citing paper
“Delayed treatment in congenital hypothyroidism can lead to permanent brain damage.”
From Risks of suboptimal and excessive thyroid hormone replacement across ages (2023) · cites this paper as [19]
In the citing paper
“Therefore, children still develop cretinism [19].”
From Risks of suboptimal and excessive thyroid hormone replacement across ages (2023) · cites this paper as [19]
In the citing paper
“However, despite the available dried blood spots technology since the early 1970s, approximately 70% of the world’s population does not have access to it.”
From Risks of suboptimal and excessive thyroid hormone replacement across ages (2023) · cites this paper as [19]
In the citing paper
“Despite the benefits of neonatal screening, 70% of infants worldwide are born in areas that do not have access to neonatal screening (6).”
In the citing paper
“In addition, many of these infants are born in areas of endemic iodine deficiency, placing them at increased risk of TH deficiency.”
Citations
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Hadžimuratović, E., Branković, S., Hadžimuratović, A., Hasanbegović, S., Pašić, I. S., Jesenković, D. A., Hadžimuratović, A., Opanković, E., & Agić, A. (2022) · Journal of Health Sciences · doi:10.17532/jhsci.2022.1638
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“This fact is probably associated with an increase in the survival of preterm newborns,(4,7) environmental(11) and ethnic factors,(7) as well as the reduction in the cutoff values of thyroid-stimulating hormone (TSH) on filter-paper blood-spot (b-TSH) in NS programs.(4,12) Initially, higher b-TSH cutoff values were ado…”
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Phillips, J. G., Fabian, S. B., Adkins, E. W., & Kiell, E. P. (2023) · Journal of the American Academy of Audiology · doi:10.1055/a-2165-0789
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Калинина, Е. А., Солнцева, А. В., & Зубова, Т. В. (2023) · Рецепт · doi:10.34883/pi.2023.26.5.016
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Elliyanti, A. (2024) · IntechOpen eBooks · doi:10.5772/intechopen.1005228
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Neonatal Screenings for Congenital Hypothyroidism
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Role of neonatal screening in the diagnosis of congenital hypothyroidism in newborns
Zaryankina, A. I., Sergeichik, L. S., Kozik, E. A., & Tselekhovich, O. P. (2025) · Health and Ecology Issues · doi:10.51523/2708-6011.2024-21-4-17
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Permanent Congenital Hypothyroidism in Very Low Birth Weight Infants: A Single Center’s Experience
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Bakjaji, S., Anglin, K., Clotts, T., Dorsten, B., Jones, K., Young, C., Zoofan, S., Abdel-Hadi, M., Damilano, C. P., & Obrynba, K. S. (2025) · Pediatric Quality and Safety · doi:10.1097/pq9.0000000000000844
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Thyroid Peroxidase Gene Mutations Associated with Thyroid Disorders
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Kostné prejavy porúch štítnej žľazy
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New molecular insights in pathogenesis of congenital hypothyroidism
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Tamizaje neonatal, diagnóstico y tratamiento del hipotiroidismo congénito: revisión sistemática
Barragán-Rodríguez, G. L., Ibarra-Guevara, J. Z., Sacón-Meunier, K. J., & Castellano-Castellano, F. G. (2026) · Cuaderno de odontología. Revista científica. · doi:10.62574/tix1bav4
Metadata
- Authors
- Ford, G., & LaFranchi, S. H.
- Affiliations
- Oregon Health & Science University (US)
- Corresponding author
- LaFranchi, Stephen H.
- Venue
- Best Practice & Research Clinical Endocrinology & Metabolism
- Publisher
- Elsevier BV
- Published
- 2014-03
- Volume
- 28
- Issue
- 2
- Pages
- 175-187
- ISSN
- 1521-690X (ISSN-L)
- OpenAlex
- W2040203752
- Cited by
- 274
- References
- 70
- Citations by year
- 2026: 12 · 2025: 25 · 2024: 19 · 2023: 31 · 2022: 28 · 2021: 43 · 2020: 30 · 2019: 14 · 2018: 22 · 2017: 19 · 2016: 15 · 2015: 11 · 2014: 4
- FWCI
- 1.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Best Practice & Research Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Metabolism and Genetic Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genomics and Rare Diseases
- Keywords
- congenital hypothyroidism, newborn screening, screening incidence, intellectual disability, transient hypothyroidism, screening coverage, thyroid imaging
- MeSH terms
- Cost-Benefit Analysis, Congenital Hypothyroidism, Developing Countries, Humans, Infant, Infant, Newborn, Intellectual Disability, Thyrotropin, Thyroxine, Incidence, Neonatal Screening
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