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Characterization and comparison of ATF and TFF in stirred bioreactors for continuous mammalian cell culture processes

Karst, Daniel J., Serra, Elisa, Villiger, Thomas K., Soos, Miroslav, Morbidelli, Massimo·2016·Biochemical Engineering Journal

DOI 10.1016/j.bej.2016.02.003

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Authors: Karst, D. J., Serra, E., Villiger, T. K., Soos, M., & Morbidelli, M.
Affiliations: ETH Zurich (CH)
Corresponding author: Morbidelli, Massimo
ORCID: Villiger, Thomas K.
Morbidelli, Massimo
Venue: Biochemical Engineering Journal
Publisher: Elsevier BV
Published: 2016-06
Volume: 110
Pages: 17-26
ISSN: 1369-703X (ISSN-L)
DOI: 10.1016/j.bej.2016.02.003
OpenAlex: W2258522366
Cited by: 151
References: 52
Citations by year: 2026: 6 · 2025: 5 · 2024: 14 · 2023: 11 · 2022: 13 · 2021: 20 · 2020: 22 · 2019: 19 · 2018: 25 · 2017: 10 · 2016: 3
FWCI: 9.88
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biochemical Engineering Journal (publishedVersion)
Virtual Community of Pathological Anatomy (University of Castilla La Mancha) (submittedVersion)
Funders: SNF (206021_150744/1)
University Research grant of UCT
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Viral Infectious Diseases and Gene Expression in Insects
Physical Sciences › Chemical Engineering › Fluid Flow and Transfer Processes › Fluid Dynamics and Mixing
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein purification and stability
Keywords: cross-flow filtration, cell retention, stirred tank reactor, mammalian cell culture, CHO cells, bioreactor hydrodynamics, oxygen transfer, scale-up

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Characterization and comparison of ATF and TFF in stirred bioreactors for continuous mammalian cell culture processes

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