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Cited by 83Wound Healing and TreatmentsTissue Engineering and Regenerative MedicineElectrospun Nanofibers in Biomedical Applications

Copper ion/gallic acid MOFs-laden adhesive pomelo peel sponge effectively treats biofilm-infected skin wounds and improves healing quality

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Yang, Jianqiu, Huang, Zhenzhen, Tan, Jiang, Pan, Jingye, Chen, Shixuan, Wan, Wenbing·2024·Bioactive Materials
DOI 10.1016/j.bioactmat.2023.10.005PMC PMC10589730
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Abstract

Bacterial infection and scar formation remain primary challenges in wound healing. To address these issues, we developed a decellularized pomelo peel (DPP) functionalized with an adhesive PVA-TSPBA hydrogel and antibacterial gallic acid/copper MOFs. The hybrid wound dressing demonstrates favorable biocompatibility. It does not impede the proliferation of fibroblasts or immune cells and can stimulate fibroblast migration, endothelial angiogenesis, and M2 macrophage polarization. Additionally, the dressing can scavenge reactive oxygen species (ROS) and provide antioxidant effects. Furthermore, DPP+MOF@Gel effectively inhibits the viability of S. aureus and E. coli in vitro and in vivo. The histological observations revealed enhanced granulation tissue formation, re-epithelialization, and angiogenesis in the DPP+MOF@Gel group compared to other groups. The local immune response also shifted from a pro-inflammatory to a pro-regenerative status with DPP+MOF@Gel treatment. The skin incision stitching experiment further exhibits DPP+MOF@Gel could reduce scar formation during wound healing. Taken together, the hybrid DPP+MOF@Gel holds great promise for treating bacteria-infected skin wounds and inhibiting scar formation during wound healing.

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  • Copper-containing biomaterials promote healing of infected wounds, including MRSA and Escherichia coli biofilm.

    “Additionally, copper-containing biomaterials, mostly wound dressings, have shown significant potential in promoting the healing of infected wounds [68,87,91,92,93,94,95,96,97,98], including those infected with MRSA [99] and Escherichia coli biofilm [100].”

    From The Journey of Copper-Impregnated Dressings in Wound Healing: From a Medical Hypothesis to Clinical Practice (2025) · cites this paper as [91]

    The Results and discussion section reports faster healing of S. aureus-infected wounds treated with the copper-containing dressing. The Methods section tests E. coli only for in vitro antibacterial activity; the biofilm-infected wound model uses S. aureus, not E. coli. Thus this paper does not support the E. coli-biofilm wound-healing example attributed to it. (LLM, conf=0.88)

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Cited by

Sorted by citations

Authors
Yang, J., Huang, Z., Tan, J., Pan, J., Chen, S., & Wan, W.
Affiliations
  • Second Affiliated Hospital of Nanchang University (CN)
  • Wenzhou Institute, University of Chinese Academy of Sciences (CN)
  • First Affiliated Hospital of Wenzhou Medical University (CN)
Corresponding author
  • Pan, Jingye
  • Chen, Shixuan
  • Wan, Wenbing
ORCID
Venue
Bioactive Materials
Publisher
Elsevier BV
Published
2024-02
Volume
32
Pages
260-276
ISSN
  • 2097-1192 (ISSN-L)
  • 2452-199X
DOI
10.1016/j.bioactmat.2023.10.005
PMC
PMC10589730
OpenAlex
W4387627552
Cited by
83
References
1
Citations by year
2026: 14 · 2025: 38 · 2024: 29 · 2023: 2
FWCI
9.14
Type
journal article
Language
en
Open access
Licence
Locations
  • Bioactive Materials (publishedVersion, cc-by-nc-nd)
  • SSRN Electronic Journal (acceptedVersion)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
  • National Natural Science Foundation of China (82102334, 82272204, 82360446)
  • Science and Technology Plan Project of Wenzhou Municipality (2023C03084, ZY2022026)
Topics
  • Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
  • Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
  • Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
Keywords
wound dressings, antibacterial hydrogel, scar formation, wound healing, reactive oxygen species scavenging, M2 macrophage polarization, angiogenesis, fibroblast migration, Staphylococcus aureus, Escherichia coli, re-epithelialization, granulation tissue

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