VISA—A pass to innate immunity
Abstract
Virus-induced signaling adaptor (VISA) is essential for host innate immune responses against double-stranded RNA viral infection and viral replication. It is an adaptor that activates the transcription factors nuclear factor kappaB (NF-kappaB) and interferon regulatory factor 3 (IRF3) that regulate the expression of type I interferons. The localization of VISA to the outer membrane of mitochondria and the cellular consequences of its activation implicate this protein in the cellular etiology of neurodegenerative disorders.
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An efficient antiviral adaptive response is thought to be of the Th1 type.
“As reviewed above, an efficient antiviral adaptive response is thought to be of the Th1 type (225).”
From The airway epithelium: soldier in the fight against respiratory viruses (2011) · cites this paper as [225]
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References 20 · Cited by 18
- Authors
- Qi, B., Huang, Y., Rowe, D., & Halliday, G.
- Affiliations
- Harbin Medical University (CN)
- UNSW Sydney (AU)
- The University of Sydney (AU)
- Corresponding author
- Halliday, Glenda
- Venue
- The International Journal of Biochemistry & Cell Biology
- Publisher
- Elsevier BV
- Published
- 2007
- Volume
- 39
- Issue
- 2
- Pages
- 287-291
- ISSN
- 1357-2725 (ISSN-L)
- OpenAlex
- W1983326322
- Cited by
- 18
- References
- 20
- Citations by year
- 2026: 1 · 2019: 1 · 2018: 1 · 2015: 1 · 2014: 3 · 2013: 1 · 2012: 2
- FWCI
- 0.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The International Journal of Biochemistry & Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- Visa, innate immunity, double-stranded RNA virus, NF-κB, IRF3, type I interferon, mitochondrial outer membrane, neurodegenerative diseases, antiviral signaling
- MeSH terms
- Animals, Humans, Immunity, Innate, Interferon Type I, Mitochondria, RNA, Double-Stranded, Virus Replication, Viruses, Signal Transduction, NF-kappa B, Adaptor Proteins, Signal Transducing, Interferon Regulatory Factor-3, Interferon Regulatory Factor-7
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