Dorsomorphin and LDN-193189 inhibit BMP-mediated Smad, p38 and Akt signalling in C2C12 cells

Boergermann, J.H.; Kopf, J.; Yu, P.B.; Knaus, P.

doi:10.1016/j.biocel.2010.07.018

Dorsomorphin and LDN-193189 inhibit BMP-mediated Smad, p38 and Akt signalling in C2C12 cells

Bone morphogenetic proteins (BMPs) are key regulators of cell fate decisions during embryogenesis and tissue homeostasis. BMPs signal through a coordinated assembly of two types of transmembrane serine/ threonine kinase receptors to induce Smad1/5/8 plus non-Smad pathways, such as MAPK and Akt. T…