PIM kinases: From survival factors to regulators of cell motility
Open accessAbstract
PIM kinases are oncogenic serine/threonine kinases, the expression and activities of which are tightly regulated in normal tissues, but upregulated in many types of human malignancies, including both hematological and solid cancers. Since high PIM expression levels have been connected to cancer progression and poor patient survival, PIM kinases have become attractive targets for drug development. Many downstream targets have also been identified, through which PIM kinases promote cell survival, proliferation and metabolism. More recently, PIM kinases have been implicated in regulation of cell motility, which also plays an important role in tumor growth and cancer progression. This review summarizes effects of PIM kinases and their substrates especially on cancer cell migration, invasion and metastatic growth, based on data from cell-based assays, animal experiments and patients.
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PIM kinases are oncogenic serine/threonine kinases overexpressed in many cancers.
“Proviral Integration site for Moloney murine leukemia virus (PIM) kinases are oncogenic serine/threonine kinases overexpressed in many cancers11”
From Endothelial Pim3 kinase protects the vascular barrier during lung metastasis (2024) · cites this paper as [11]
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References 205 · Cited by 69
- Authors
- Santio, N. M., & Koskinen, P. J.
- Affiliations
- University of Turku (FI)
- Corresponding author
- Koskinen, Päivi J.
- Venue
- The International Journal of Biochemistry & Cell Biology
- Publisher
- Elsevier BV
- Published
- 2017-12
- Volume
- 93
- Pages
- 74-85
- ISSN
- 1357-2725 (ISSN-L)
- OpenAlex
- W2765322593
- Cited by
- 69
- References
- 205
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 10 · 2023: 12 · 2022: 10 · 2021: 8 · 2020: 10 · 2019: 7 · 2018: 4
- FWCI
- 0.92
- Type
- journal article
- Language
- en
- Open access
- green
- www.utupub.fi
- Locations
- The International Journal of Biochemistry & Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- UTUPub (University of Turku) (submittedVersion)
- Funders
- Academy of Finland (287040)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Cancer Mechanisms and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
- Keywords
- PIM kinases, tumor cell migration, tumor invasion, metastasis, cell motility, cell survival, cell proliferation, cancer metabolism, cancer drug targets, hematologic malignancies, solid tumors
- MeSH terms
- Animals, Cell Movement, Humans, Neoplasm Invasiveness, Neoplasm Metastasis, Neoplasms, Cell Proliferation, Proto-Oncogene Proteins c-pim-1
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