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Cited by 28Mesenchymal stem cell researchGlioma Diagnosis and TreatmentCancer Cells and Metastasis

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The impact of Mesenchymal Stem Cells and their secretome as a treatment for gliomas

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Gomes, E.D., Vieira de Castro, J., Costa, B.M., Salgado, A.J.·2018·Biochimie
DOI 10.1016/j.biochi.2018.07.008
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Abstract

In recent years, we have witnessed a significant increase in the amount of studies using Mesenchymal Stem Cells (MSCs) for cancer therapy, mostly as vectors for drug or gene delivery strategies. This is because of their intrinsic capacity of homing into tumor niches. However, the interactions between MSCs themselves and tumor cells is not fully understood, with contradictory results frequently being observed regarding their effects on cancer cell invasion and proliferation. This poses an important question of safety in respect to the application of these cells. The source of the MSC population used, as well as the type of cancer cells under study might strongly influence this interaction. Moreover, differences in isolation protocols, culture media compositions, time of culture and conditioned media collection, or even timing and mode of MSCs administration to in vivo models of cancer may also affect the interaction MSC-tumor cells. In this review, we drive our focus into malignant brain tumors, particularly gliomas, one of the deadliest forms of cancer. Moreover, we look with some detail into different studies using MSCs as a treatment for brain tumors and compare them, highlighting the main deviations and similarities among them.

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  • Many authors have reported the effect of the secretome of MSCs on tumor cell proliferation and invasion in vitro and in vivo.

    “many authors have been reported the effect of the secretome of MSCs in tumor cell proliferation and invasion in vitro and in vivo [104], [105], [106], [107].”

    From Mesenchymal stem cell secretome for regenerative medicine: Where do we stand? (2025) · cites this paper as [106]

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Metadata

Authors
Gomes, E. D., Vieira de Castro, J., Costa, B. M., & Salgado, A. J.
Affiliations
University of Minho (PT)
Corresponding author
Salgado, A.J.
ORCID
Venue
Biochimie
Publisher
Elsevier BV
Published
2018-12
Volume
155
Pages
59-66
ISSN
  • 0037-9042 (ISSN-L)
  • 0300-9084
DOI
10.1016/j.biochi.2018.07.008
OpenAlex
W2883866965
Cited by
28
References
3
Citations by year
2026: 1 · 2025: 3 · 2024: 4 · 2023: 2 · 2022: 4 · 2021: 8 · 2020: 3 · 2019: 3
FWCI
0.51
Type
journal article
Language
en
Open access
Licence
Locations
  • Biochimie (publishedVersion)
  • PubMed (publishedVersion)
  • RepositóriUM (Universidade do Minho) (submittedVersion, other-oa)
  • Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, other-oa)
Funders
  • Fundação para a Ciência e a Tecnologia (SFRH/BD/88121/2012, SFRH/BD/103075/2014, IF/00601/2012, IF/00111/2013, NORTE-01-0145-FEDER-000023, POCI-01-0145-FEDER-007038)
  • European Regional Development Fund
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
  • Health Sciences › Medicine › Oncology › Glioma Diagnosis and Treatment
  • Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Keywords
mesenchymal stem cells, glioma, secretome, cancer therapy, tumor invasion, tumor cell proliferation, brain tumors, stem cell safety, conditioned medium, tumor homing
MeSH terms
Animals, Brain Neoplasms, Glioma, Humans, Neoplasm Invasiveness, Gene Transfer Techniques, Mesenchymal Stem Cell Transplantation, Mesenchymal Stem Cells

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