Interplay between primary cilia, ubiquitin-proteasome system and autophagy
Open accessAbstract
Cilia are microtubule-based organelles located at the cell surface of many eukaryotic cell types. Cilia control different cellular functions ranging from motility (for motile cilia) to signal transduction pathways (for primary cilia). A variety of signaling pathways are coordinated by this organelle during development, cell migration and cell differentiation. Interestingly, aberrant ciliogenesis or altered cilium signaling has been associated with human diseases, notably in cancer. Disruption of cilia through mutation of genes encoding cilia proteins has been also linked to multiple human disorders referred as ciliopathies. Recent studies highlight the interplay between cilia and proteostasis. Here we review findings regarding the crosstalk between cilia and two proteolytic systems, the ubiquitin proteasome system and the autophagy-lysosomal system and discuss the potential implications in human disease including ciliopathies.
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Neuronal primary cilia are at the intersection of extracellular and intracellular signaling pathways that control the function of subcellular organelles like the proteasome, autophagosome, and microtubule-rich basal body.
“In addition, neuronal primary cilia are at the intersection of extracellular and intracellular signaling pathways that control the function of subcellular organelles like the proteasome, autophagosome, and microtubule-rich basal body [6, 57].”
From Abnormal accumulation of extracellular vesicles in hippocampal dystrophic axons and regulation by the primary cilia in Alzheimer's disease (2023) · cites this paper as [6]
Section 1 describes primary cilia as signaling hubs that respond to extracellular changes and identifies the microtubule-based axoneme and its basal body. Sections 3 and 4 describe ciliary crosstalk with proteasomal activity and autophagy. The review does not establish these relationships specifically in neuronal primary cilia, and it does not describe the basal body as an organelle whose function those signaling pathways control. (LLM, conf=0.87)
Experimental — accuracy not yet measuredPrimary cilia, which make use of mitotic spindle-like molecular machinery, may influence the regulation of the cell cycle machinery in neurons.
“Primary cilia, which make use of mitotic spindle-like molecular machinery, may influence the regulation of the cell cycle machinery in neurons [6, 57].”
From Abnormal accumulation of extracellular vesicles in hippocampal dystrophic axons and regulation by the primary cilia in Alzheimer's disease (2023) · cites this paper as [6]
Section 1, “Cilia: from structure to function” (page unavailable), says that primary cilia arise from a centrosomal centriole and that cilium formation and disassembly track the cell cycle. Section 3 identifies a centrosome-and-spindle-pole-associated protein required for cilia formation. These passages support a connection to cell-cycle and spindle-associated machinery, but do not establish that primary cilia influence regulation of cell-cycle machinery specifically in neurons. (LLM, conf=0.82)
Experimental — accuracy not yet measured
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References 55 · Cited by 35
- Authors
- Boukhalfa, A., Miceli, C., Ávalos, Y., Morel, E., & Dupont, N.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Universidad de Santiago de Chile (CL)
- Corresponding author
- Dupont, Nicolas
- Venue
- Biochimie
- Publisher
- Elsevier BV
- Published
- 2019-11
- Volume
- 166
- Pages
- 286-292
- ISSN
- 0037-9042 (ISSN-L)
- 0300-9084
- OpenAlex
- W2949347917
- Cited by
- 35
- References
- 55
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 3 · 2023: 7 · 2022: 4 · 2021: 11 · 2020: 5 · 2019: 1
- FWCI
- 0.70
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Biochimie (acceptedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion, cc-by-nc)
- Funders
- Agence Nationale de la Recherche
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Kidney Cyst Diseases
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cystic Fibrosis Research Advances
- Keywords
- primary cilia, ubiquitin-proteasome system, autophagy, proteostasis, ciliopathies, ciliogenesis, ciliary signaling, cancer
- MeSH terms
- Ciliopathies, Animals, Autophagy, Cilia, Humans, Lysosomes, Signal Transduction, Ubiquitin, Proteasome Endopeptidase Complex, Mice
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