The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
The motility of normal and cancer cells in response to the combined influence of the substrate rigidity and anisotropic microstructure
Open accessAbstract
Cell adhesion and migration are strongly influenced by extracellular matrix (ECM) architecture and rigidity, but little is known about the concomitant influence of such environmental signals to cell responses, especially when considering cells of similar origin and morphology, but exhibiting a normal or cancerous phenotype. Using micropatterned polydimethylsiloxane substrates (PDMS) with tunable stiffness (500 kPa, 750 kPa, 2000 kPa) and topography (lines, pillars or unpatterned), we systematically analyse the differential response of normal (3T3) and cancer (SaI/N) fibroblastic cells. Our results demonstrate that both cells exhibit differential morphology and motility responses to changes in substrate rigidity and microtopography. 3T3 polarisation and spreading are influenced by substrate microtopography and rigidity. The cells exhibit a persistent type of migration, which depends on the substrate anisotropy. In contrast, the dynamic of SaI/N spreading is strongly modified by the substrate topography but not by substrate rigidity. SaI/N morphology and migration seem to escape from extracellular cues: the cells exhibit uncorrelated migration trajectories and a large dispersion of their migration speed, which increases with substrate rigidity.
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Cites
Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion
Yeung, T., Georges, P. C., Flanagan, L. A., Marg, B., Ortiz, M., Funaki, M., Zahir, N., Ming, W., Weaver, V., & Janmey, P. A. (2005) · Cell Motility and the Cytoskeleton · doi:10.1002/cm.20041 · Cited by 2,325
Cell adaptation to a physiologically relevant ECM mimic with different viscoelastic properties
Ghosh, K., Pan, Z., Guan, E., Ge, S., Liu, Y., Nakamura, T., Ren, X.-D., Rafailovich, M., & Clark, R. A. F. (2007) · Biomaterials · doi:10.1016/j.biomaterials.2006.09.038 · Cited by 386
Cited by
Engineering Substrate Topography at the Micro‐ and Nanoscale to Control Cell Function
Bettinger, C. J., Langer, R., & Borenstein, J. T. (2009) · Angewandte Chemie International Edition · doi:10.1002/anie.200805179 · Cited by 1,258
Bacakova, L., Filova, E., Parizek, M., Ruml, T., & Svorcik, V. (2011) · Biotechnology Advances · doi:10.1016/j.biotechadv.2011.06.004 · Cited by 1,000
PDMS with designer functionalities—Properties, modifications strategies, and applications
Wolf, M. P., Salieb-Beugelaar, G. B., & Hunziker, P. (2018) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2018.06.001 · Cited by 853
Yim, E. K. F., Darling, E. M., Kulangara, K., Guilak, F., & Leong, K. W. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2009.10.037 · Cited by 712
Engineering microscale topographies to control the cell–substrate interface
Nikkhah, M., Edalat, F., Manoucheri, S., & Khademhosseini, A. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.03.079 · Cited by 640
Metadata
- Authors
- Tzvetkova-Chevolleau, T., Stéphanou, A., Fuard, D., Ohayon, J., Schiavone, P., & Tracqui, P.
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2008-04
- Volume
- 29
- Issue
- 10
- Pages
- 1541-1551
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W1983744704
- Cited by
- 172
- References
- 2
- FWCI
- 5.65
- Type
- journal article
- Language
- en
- Open access
- green
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- Tzvetkova-Chevolleau, T., Stéphanou, A., Fuard, D., Ohayon, J., Schiavone, P., & Tracqui, P. (2008). The motility of normal and cancer cells in response to the combined influence of the substrate rigidity and anisotropic microstructure. Biomaterials. https://doi.org/10.1016/j.biomaterials.2007.12.016
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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