The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Bone regeneration mediated by biomimetic mineralization of a nanofiber matrix
Open accessAbstract
Rapid bone regeneration within a three-dimensional defect without the use of bone grafts, exogenous growth factors, or cells remains a major challenge. We report here on the use of self-assembling peptide nanostructured gels to promote bone regeneration that have the capacity to mineralize in biomimetic fashion. The main molecular design was the use of phosphoserine residues in the sequence of a peptide amphiphile known to nucleate hydroxyapatite crystals on the surfaces of nanofibers. We tested the system in a rat femoral critical size defect by placing pre-assembled nanofiber gels in a 5 mm gap and analyzed bone formation with micro-computed tomography and histology. We found within 4 weeks significantly higher bone formation relative to controls lacking phosphorylated residues and comparable bone formation to that observed in animals treated with a clinically used allogenic bone matrix.
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Cites
Osteoclast differentiation and activation
Boyle, W. J., Simonet, W. S., & Lacey, D. L. (2003) · Nature · doi:10.1038/nature01658 · Cited by 6,670 · cited 1×
“Furthermore, this HA-containing nichemay also be stimulating osteoclast activity [51], which would subsequently stimulate osteoblasts to begin the formation of new bone [52].”
BackgroundGiannoudis, P. V., Dinopoulos, H., & Tsiridis, E. (2005) · Injury · doi:10.1016/j.injury.2005.07.029 · Cited by 2,078
Cited by
Supramolecular Chemistry and Self-Assembly in Organic Materials Design
Stupp, S. I., & Palmer, L. C. (2014) · Chemistry of Materials · doi:10.1021/cm403028b · Cited by 513
Self-citationAdvances in synthesis of calcium phosphate crystals with controlled size and shape
Lin, K., Wu, C., & Chang, J. (2014) · Acta Biomaterialia · doi:10.1016/j.actbio.2014.06.017 · Cited by 414
Design and applications of man-made biomimetic fibrillar hydrogels
Prince, E., & Kumacheva, E. (2019) · Nature Reviews Materials · doi:10.1038/s41578-018-0077-9 · Cited by 379
Cheetham, A. G., Chakroun, R. W., Ma, W., & Cui, H. (2017) · Chem. Soc. Rev. · doi:10.1039/c7cs00521k · Cited by 367
Pathway Selection in Peptide Amphiphile Assembly
Korevaar, P. A., Newcomb, C. J., Meijer, E. W., & Stupp, S. I. (2014) · Journal of the American Chemical Society · doi:10.1021/ja503882s · Cited by 265
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Metadata
- Authors
- Mata, A., Geng, Y., Henrikson, K. J., Aparicio, C., Stock, S. R., Satcher, R. L., & Stupp, S. I.
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2010-08
- Volume
- 31
- Issue
- 23
- Pages
- 6004-6012
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W2029491390
- Cited by
- 260
- References
- 2
- FWCI
- 13.29
- Type
- journal article
- Language
- en
- Open access
- green
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- Mata, A., Geng, Y., Henrikson, K. J., Aparicio, C., Stock, S. R., Satcher, R. L., & Stupp, S. I. (2010). Bone regeneration mediated by biomimetic mineralization of a nanofiber matrix. Biomaterials. https://doi.org/10.1016/j.biomaterials.2010.04.013
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