FRET-enabled biological characterization of polymeric micelles
Open accessAbstract
Translation of micelles from the laboratory to the clinic is limited by a poor understanding of their in vivo fate following administration. In this paper, we establish a robust approach to real-time monitoring of the in vivo stability of micelles using Förster Resonance Energy Transfer (FRET). This characterization method allows for exquisite insight into the fate of micellar constituents, affording the capabilities to rapidly and efficiently evaluate a library of synthetically derived micellar systems as new therapeutic platforms in vivo. FRET-enabled biological characterization further holds potential to tailor material systems being uniquely investigated across the delivery community towards the next generation of stable therapeutics for disease management.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
FRET occurs only if two conditions are respected: partial overlap between the emission spectrum of the donor and the excitation spectrum of the acceptor, and the two dyes must be in close proximity (1-10 nm).
“FRET occurs only if two conditions are respected.The first one is the partial overlap between the emission spectrum of the donor and the excitation spectrum of the acceptor, to produce enough energy for dipole-dipole coupling.The second one is that the two dyes must be in close proximity (distances in the range between 1-10 nm) [91,229].”
From Polymeric micelles in drug delivery: An insight of the techniques for their characterization and assessment in biorelevant conditions (2021) · cites this paper as [229]
In the paper's discussion of FRET (section labeled Abstract; page unavailable), Morton states that energy transfer occurs only when the dyes are close and identifies the Förster-distance range. The discussion of Figure 2A also identifies overlap between donor emission and acceptor absorption as making the dyes a good FRET pair. Our copy does not specify the claimed 1–10 nm distance range. (LLM, conf=0.87)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 27 · Cited by 88
Research works printed but not linked: 1
- [1]Zhao XY Poon Z Engler AC Bonner DK Hammond PT Biomacromolecules 2012 13 5 1315 1322 22376183 PMC3387562
- Authors
- Morton, S. W., Zhao, X., Quadir, M. A., & Hammond, P. T.
- Affiliations
- Koch Institute for Integrative Cancer Research At MIT (US)
- Institute for Soldier Nanotechnologies (US)
- Corresponding author
- Hammond, Paula T.
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2014-04
- Volume
- 35
- Issue
- 11
- Pages
- 3489-3496
- ISSN
- 0142-9612 (ISSN-L)
- PMC
- PMC4040354
- OpenAlex
- W2040733866
- Cited by
- 88
- References
- 27
- Citations by year
- 2026: 7 · 2025: 8 · 2024: 7 · 2023: 5 · 2022: 8 · 2021: 7 · 2020: 8 · 2019: 7 · 2018: 6 · 2017: 11 · 2016: 9 · 2015: 3 · 2014: 2
- FWCI
- 3.14
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biomaterials (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc-nd)
- Funders
- National Cancer Institute (P30-CA14051)
- internal David H. Koch Nanoparticle
- NIH Challenge (5 U54 CA151884-02)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Physical Sciences › Chemistry › Organic Chemistry › Surfactants and Colloidal Systems
- Keywords
- polymeric micelles, fluorescence resonance energy transfer, in vivo stability, real-time monitoring, drug delivery, therapeutics
- MeSH terms
- Animals, Female, Fluorescent Dyes, Light, Mice, Inbred BALB C, Mice, Nude, Micelles, Polymers, Scattering, Radiation, Tissue Distribution, Fluorescence Resonance Energy Transfer, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
