The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
The effects of graphene nanostructures on mesenchymal stem cells
Open accessAbstract
We report the effects of two-dimensional graphene nanostructures; graphene nano-onions (GNOs), graphene oxide nanoribbons (GONRs), and graphene oxide nanoplatelets (GONPs) on viability, and differentiation of human mesenchymal stem cells (MSCs). Cytotoxicity of GNOs, GONRs, and GONPs dispersed in distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(polyethylene glycol)] (DSPE-PEG), on adipose derived mesenchymal stem cells (adMSCs), and bone marrow-derived mesenchymal stem cells (bmMSCs) was assessed by AlamarBlue and Calcein AM viability assays at concentrations ranging from 5–300 μg/ml for 24 or 72 hours. Cytotoxicity of the 2D graphene nanostructures was found to be dose dependent, not time dependent, with concentrations less than 50 μg/ml showing no significant differences compared to untreated controls. Differentiation potential of adMSCs to adipocytes and osteoblasts, --characterized by Oil Red O staining and elution, alkaline phosphatase activity, calcium matrix deposition and Alizarin Red S staining-- did not change significantly when treated with the three graphene nanoparticles at a low (10 μg/ml) and high (50 μg/ml) concentration for 24 hours. Transmission electron microscopy (TEM) and confocal Raman spectroscopy indicated cellular uptake of only GNOs and GONPs. The results lay the foundation for the use of these nanoparticles at potentially safe doses as ex vivo labels for MSC-based imaging and therapy.
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One‐Dimensional Nanostructures: Synthesis, Characterization, and Applications
Xia, Y., Yang, P., Sun, Y., Wu, Y., Mayers, B., Gates, B., Yin, Y., Kim, F., & Yan, H. (2003) · Advanced Materials · doi:10.1002/adma.200390087 · Cited by 8,559
O'Brien, J., Wilson, I., Orton, T., & Pognan, F. (2000) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2000.01606.x · Cited by 3,446
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Singh, D. P., Herrera, C. E., Singh, B., Singh, S., Singh, R. K., & Kumar, R. (2018) · Materials Science and Engineering: C · doi:10.1016/j.msec.2018.01.004 · Cited by 313
Toxicology of graphene-based nanomaterials
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Self-citationEnhanced Osteogenesis by Reduced Graphene Oxide/Hydroxyapatite Nanocomposites
Lee, J. H., Shin, Y. C., Lee, S.-M., Jin, O. S., Kang, S. H., Hong, S. W., Jeong, C.-M., Huh, J. B., & Han, D.-W. (2015) · Scientific Reports · doi:10.1038/srep18833 · Cited by 258
Metadata
- Authors
- Talukdar, Y., Rashkow, J. T., Lalwani, G., Kanakia, S., & Sitharaman, B.
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2014-06
- Volume
- 35
- Issue
- 18
- Pages
- 4863-4877
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W2012565848
- Cited by
- 235
- References
- 2
- FWCI
- 13.24
- Type
- journal article
- Language
- en
- Open access
- green
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- Talukdar, Y., Rashkow, J. T., Lalwani, G., Kanakia, S., & Sitharaman, B. (2014). The effects of graphene nanostructures on mesenchymal stem cells. Biomaterials. https://doi.org/10.1016/j.biomaterials.2014.02.054
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