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In vivo tumor-targeted dual-modal fluorescence/CT imaging using a nanoprobe co-loaded with an aggregation-induced emission dye and gold nanoparticles
Open accessAbstract
As an intensely studied computed tomography (CT) contrast agent, gold nanoparticle has been suggested to be combined with fluorescence imaging modality to offset the low sensitivity of CT. However, the strong quenching of gold nanoparticle on fluorescent dyes requires complicated design and shielding to overcome. Herein, we report a unique nanoprobe (M-NPAPF-Au) co-loading an aggregation-induced emission (AIE) red dye and gold nanoparticles into DSPE-PEG2000 micelles for dual-modal fluorescence/CT imaging. The nanoprobe was prepared based on a facile method of “one-pot ultrasonic emulsification”. Surprisingly, in the micelles system, fluorescence dye (NPAPF) efficiently overcame the strong fluorescence quenching of shielding-free gold nanoparticles and retained the crucial AIE feature. In vivo studies demonstrated the nanoprobe had superior tumor-targeting ability, excellent fluorescence and CT imaging effects. The totality of present studies clearly indicates the significant potential application of M-NPAPF-Au as a dual-modal non-invasive fluorescence/X-ray CT nanoprobe for in vivo tumor-targeted imaging and diagnosis.
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Hong, Y., Lam, J. W. Y., & Tang, B. Z. (2011) · Chemical Society Reviews · doi:10.1039/c1cs15113d · Cited by 6,363
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Mei, J., Leung, N. L. C., Kwok, R. T. K., Lam, J. W. Y., & Tang, B. Z. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00263 · Cited by 8,270
Aggregation‐Induced Emission: Recent Advances in Materials and Biomedical Applications
Cai, X., & Liu, B. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.202000845 · Cited by 796
Unique Roles of Gold Nanoparticles in Drug Delivery, Targeting and Imaging Applications
Kong, F.-Y., Zhang, J.-W., Li, R.-F., Wang, Z.-X., Wang, W.-J., & Wang, W. (2017) · Molecules · doi:10.3390/molecules22091445 · Cited by 615
Self-citationPolymeric AIE-based nanoprobes for biomedical applications: recent advances and perspectives
Zhang, X., Wang, K., Liu, M., Zhang, X., Tao, L., Chen, Y., & Wei, Y. (2015) · Nanoscale · doi:10.1039/c5nr01444a · Cited by 508
Self-citationZhang, C., Yan, K., Fu, C., Peng, H., Hawker, C. J., & Whittaker, A. K. (2022) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00632 · Cited by 493
Metadata
- Authors
- Zhang, J., Li, C., Zhang, X., Huo, S., Jin, S., An, F.-F., Wang, X., Xue, X., Okeke, C. I., Duan, G., Guo, F., Zhang, X., Hao, J., Wang, P. C., Zhang, J., & Liang, X.-J.
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2015-02
- Volume
- 42
- Pages
- 103-111
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W1972112409
- Cited by
- 179
- References
- 1
- FWCI
- 8.19
- Type
- journal article
- Language
- en
- Open access
- green
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- Zhang, J., Li, C., Zhang, X., Huo, S., Jin, S., An, F.-F., Wang, X., Xue, X., Okeke, C. I., Duan, G., Guo, F., Zhang, X., Hao, J., Wang, P. C., Zhang, J., & Liang, X.-J. (2015). In vivo tumor-targeted dual-modal fluorescence/CT imaging using a nanoprobe co-loaded with an aggregation-induced emission dye and gold nanoparticles. Biomaterials. https://doi.org/10.1016/j.biomaterials.2014.11.053
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