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Catalase-loaded cisplatin-prodrug-constructed liposomes to overcome tumor hypoxia for enhanced chemo-radiotherapy of cancer
Abstract
Aiming at improved therapeutic efficacies, the combination of chemotherapy and radiotherapy (chemo-radiotherapy) has been widely studied and applied in clinic. However, the hostile characteristics of tumor microenvironment such as hypoxia often limit the efficacies in both types of cancer therapies. Herein, catalase (CAT), an antioxidant enzyme, is encapsulated inside liposomes constituted by cisplatin (IV)-prodrug-conjugated phospholipid, forming CAT@Pt (IV)-liposome for enhanced chemo-radiotherapy of cancer. After being loaded inside liposomes, CAT within CAT@Pt (IV)-liposome shows retained and well-protected enzyme activity, and is able to trigger decomposition of H 2 O 2 produced by tumor cells, so as to produce additional oxygen for hypoxia relief. As the result, treatment of CAT@Pt (IV)-liposome induces the highest level of DNA damage in cancer cells after X-ray radiation compared to the control groups. In vivo tumor treatment further demonstrates a remarkably improved therapeutic outcome in chemo-radiotherapy with such CAT@Pt (IV)-liposome nanoparticles. Hence, an exquisite type of liposome-based nanoparticles is developed in this work by integrating cisplatin-based chemotherapy and catalase-induced tumor hypoxia relief together for combined chemo-radiotherapy with great synergistic efficacy, promising for clinical translation in cancer treatment.
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“Specifically, in situ generation of oxygen using catalase as an enzyme is attractive because it is self-responsive to hydrogen peroxide (H2O2) and does not require pre-treatment with oxygen ( 3 O2).18,19,24”
From Catalase-Integrated Hyaluronic Acid as Nanocarriers for Enhanced Photodynamic Therapy in Solid Tumor (2019) · cites this paper as [19]
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Metadata
- Authors
- Zhang, R., Song, X., Liang, C., Yi, X., Song, G., Chao, Y., Yang, Y., Yang, K., Feng, L., & Liu, Z.
- Affiliations
- Soochow University (CN)
- Corresponding author
- Feng, Liangzhu
- Liu, Zhuang
- ORCID
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2017-09
- Volume
- 138
- Pages
- 13-21
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W2616024862
- Cited by
- 255
- References
- 45
- Citations by year
- 2026: 8 · 2025: 16 · 2024: 21 · 2023: 31 · 2022: 41 · 2021: 34 · 2020: 39 · 2019: 34 · 2018: 25 · 2017: 6
- FWCI
- 12.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biomaterials (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Science and Technology (MOST) of China (2016YFA0201200)
- National Natural Science Fundation of China (51525203)
- Collaborative Innovation Center of Suzhou Nano Science and Technology
- Priority Academic Program Development (PAPD) of Jiangsu Higher Education Institutions
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Physics and Astronomy › Radiation › Radiation Therapy and Dosimetry
- Keywords
- catalase, cisplatin prodrug, liposomes, tumor hypoxia, chemoradiotherapy, radiotherapy, hydrogen peroxide decomposition, DNA damage, tumor microenvironment, cancer therapy
- MeSH terms
- Tumor Hypoxia, Animals, Antineoplastic Agents, Antioxidants, Catalase, Cisplatin, DNA Damage, Female, Hydrogen Peroxide, Liposomes, Mice, Inbred BALB C, Neoplasms, Neoplasms, Experimental, Phospholipids, Prodrugs, Cell Line, Tumor, Mice, Nanoparticles, Chemoradiotherapy
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