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Magnetic-induced graphene quantum dots for imaging-guided photothermal therapy in the second near-infrared window

Liu, Hongji, Li, Changwei, Qian, Yong, Hu, Lin, Fang, Jun, Tong, Wei, Nie, Rongrong, Chen, Qianwang, Wang, Hui·2020·Biomaterials

Abstract

Graphene quantum dots (GQDs) are considered emerging nanomaterials for photothermal therapy (PTT) of cancer due to their good biocompatibility and rapid excretion. However, the optical absorbance of GQDs in shorter wavelengths (<1000 nm) limits their overall therapeutic efficacies as photothermal agent in the second near infrared window (1000-1700 nm, NIR-II). Herein, we report a type of GQDs with strong absorption (1070 nm) in NIR-II region that was synthesized via a one-step solvothermal treatment using phenol as single precursor by tuning the decomposition of hydrogen peroxide under a high magnetic field with an intensity of 9T. The obtained 9T-GQDs demonstrate uniform size distribution (3.6 nm), and tunable fluorescence (quantum yield, 16.67%) and high photothermal conversion efficacy (33.45%). In vitro and in vivo results indicate that 9T-GQDs could efficiently ablate tumor cells and inhibit the tumor growth under NIR-II irradiation. Moreover, the 9T-GQDs exhibited enhanced NIR imaging of tumor in living mice, suggesting the great probability of using 9T-GQDs for in vivo NIR imaging-guided PTT in the NIR-II window.

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Metadata

Authors
Liu, H., Li, C., Qian, Y., Hu, L., Fang, J., Tong, W., Nie, R., Chen, Q., & Wang, H.
Venue
Biomaterials
Publisher
Elsevier BV
Published
2020-02
Volume
232
Pages
119700
ISSN
0142-9612 (ISSN-L)
OpenAlex
W2996464793
Cited by
195
References
3
FWCI
8.38
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Magnetic-induced graphene quantum dots for imaging-guided photothermal therapy in the second near-infrared window. https://app.cochat.ai/papers/10.1016/j.biomaterials.2019.119700
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Liu, H., Li, C., Qian, Y., Hu, L., Fang, J., Tong, W., Nie, R., Chen, Q., & Wang, H. (2020). Magnetic-induced graphene quantum dots for imaging-guided photothermal therapy in the second near-infrared window. Biomaterials. https://doi.org/10.1016/j.biomaterials.2019.119700

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