Targeted silver nanoparticles for rheumatoid arthritis therapy via macrophage apoptosis and Re-polarization

Yang, Yihua; Guo, Lina; Wang, Zhe; Liu, Peng; Liu, Xuanjun; Ding, Jinsong; Zhou, Wenhu

doi:10.1016/j.biomaterials.2020.120390

Targeted silver nanoparticles for rheumatoid arthritis therapy via macrophage apoptosis and Re-polarization

Infiltration of inflammatory cells, especially the M1 macrophages that secrete various types of inflammation cytokines, play crucial roles in the pathogenesis of rheumatoid arthritis (RA). To relief synovial inﬂammation, M1 macrophages must be eliminated or switched to anti-inﬂammatory M2 phenoty…