Low-intensity focused ultrasound-augmented Cascade chemodynamic therapy via boosting ROS generation

Deng, Liming; Liu, Mingzhu; Sheng, Danli; Luo, Yuanli; Wang, Dong; Yu, Xian; Wang, Zhigang; Ran, Haitao; Li, Pan

doi:10.1016/j.biomaterials.2021.120710

Low-intensity focused ultrasound-augmented Cascade chemodynamic therapy via boosting ROS generation

Fenton reaction-mediated chemodynamic therapy (CDT), which destroys tumor cells by converting H2O2 into cytotoxic hydroxyl radical (OH) and singlet oxygen (1O2) species, is a promising field. However, Fenton-based CDT is severely impaired by the inappropriate tumor environment associated with und…