The influence of probiotics on bile acids in diseases and aging
Open accessAbstract
Recent evidence indicates the use of probiotics in the prevention and treatment of diseases. Probiotics are capable of changing the gut microbiota composition and bile acid synthesis to elicit health benefits such as cholesterol-lowering, weight reduction, and improving insulin sensitivity. The aging population is prone to develop diseases because of their decreased physiological and biological systems. Probiotics are one of the promising supplements that may potentially counteract these detrimental effects. This review will discuss the influence of probiotics on bile acids in different populations-the elderly, obese individuals, and those with hypercholesterolemia, type 2 diabetes, hypertension, and non-alcoholic fatty liver disease.
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Cholesterol reduction by probiotics seems to be mediated by different mechanisms.
“Cholesterol reduction by probiotics seems to be mediated by different mechanisms.31”
From <i>Lactiplantibacillus plantarum</i> strains KABP011, KABP012, and KABP013 modulate bile acids and cholesterol metabolism in humans (2024) · cites this paper as [31]
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References 80 · Cited by 73
- Authors
- Sivamaruthi, B. S., Fern, L. A., Rashidah Pg Hj Ismail, D. S. N., & Chaiyasut, C.
- Affiliations
- Chiang Mai University (TH)
- Universiti Brunei Darussalam (BN)
- Corresponding author
- Chaiyasut, Chaiyavat
- Venue
- Biomedicine & Pharmacotherapy
- Publisher
- Elsevier BV
- Published
- 2020-08
- Volume
- 128
- Pages
- 110310
- ISSN
- 0753-3322 (ISSN-L)
- OpenAlex
- W3033267330
- Cited by
- 73
- References
- 80
- Citations by year
- 2026: 7 · 2025: 16 · 2024: 15 · 2023: 13 · 2022: 8 · 2021: 11 · 2020: 3
- FWCI
- 0.74
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Biomedicine & Pharmacotherapy (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Chiang Mai University
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- probiotics, bile acids, gut microbiota, aging, obesity, hypercholesterolemia, type 2 diabetes, hypertension, non-alcoholic fatty liver disease, cholesterol lowering, insulin sensitivity, weight loss
- MeSH terms
- Gastrointestinal Microbiome, Age Factors, Aging, Amidohydrolases, Animals, Bile Acids and Salts, Diabetes Mellitus, Type 2, Humans, Hypercholesterolemia, Hypertension, Intestines, Obesity, Probiotics, Non-alcoholic Fatty Liver Disease
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