The DOI matches its Crossref record; 64 of the 64 references it cites were found in a registry or an index.
An update on β-sitosterol: A potential herbal nutraceutical for diabetic management
Open accessAbstract
Phytosterols are bioactive compounds that are naturally present in plant cell membranes with chemical structure similar to the mammalian cell- derived cholesterol. They are highly present in lipid-rich plant foods such as nuts, seed, legumes and olive oil. Among various phytosterols, β-sitosterol (SIT) is the major compound, found plentiful in plants. It has been evidenced in many in-vitro and in-vivo studies that SIT possesses various biological actions such as anxiolytic & sedative effects, analgesic, immunomodulatory, antimicrobial, anticancer, anti - inflammatory, lipid lowering effect, hepatoprotective, protective effect against NAFLD and respiratory diseases, wound healing effect, antioxidant and anti-diabetic activities. In this review, in order to compile the sources, characterization, biosynthesis, pharmacokinetics, antioxidant and anti-diabetic activities of SIT, classical and online-literature were studied which includes the electronic search (Sci Finder, Pubmed, Google Scholar, Scopus, and Web of Science etc) and books on photochemistry. The experimental studies on SIT gives a clear evidence that the potential phytosterol can be used as supplements to fight against life threatening diseases. High potential of this compound, classifies it as the notable drug of the future. Therefore, immense researches regarding its action at molecular level on life threatening diseases in humans are highly endorsed.
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Cites
Oxidative stress, aging, and diseases
Liguori, I., Russo, G., Curcio, F., Bulli, G., Aran, L., Della-Morte, D., Gargiulo, G., Testa, G., Cacciatore, F., Bonaduce, D., et al. (2018) · Clinical Interventions in Aging · doi:10.2147/cia.s158513 · Cited by 3,979
Type 2 diabetes mellitus, oxidative stress and inflammation: examining the links.
Oguntibeju, O. O. (2019) · Europe PMC (PubMed Central) · Cited by 758
Medicinal Natural Products: A Biosynthetic Approach
Kite, G., & Dewick, P. M. (1998) · Kew Bulletin · doi:10.2307/4114524 · Cited by 737
Plant sterol and stanol margarines and health
Law, M. (2000) · BMJ · doi:10.1136/bmj.320.7238.861 · Cited by 729
Medicinal natural products. A biosynthetic approach
Heinrich, M. (2002) · Journal of Ethnopharmacology · doi:10.1016/s0378-8741(02)00014-4 · Cited by 663
The Story of Beta-sitosterol- A Review
Saeidnia, S. (2014) · European Journal of Medicinal Plants · doi:10.9734/ejmp/2014/7764 · Cited by 357
Sterol content of foods of plant origin
WEIHRAUCH, J. L., & GARDNER, J. M. (1978) · Journal of the American Dietetic Association · doi:10.1016/s0002-8223(21)05668-6 · Cited by 351
Plant cholesterol biosynthetic pathway overlaps with phytosterol metabolism
Sonawane, P. D., Pollier, J., Panda, S., Szymanski, J., Massalha, H., Yona, M., Unger, T., Malitsky, S., Arendt, P., Pauwels, L., et al. (2016) · Nature Plants · doi:10.1038/nplants.2016.205 · Cited by 336
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Antioxidant Effects of Phytosterol and Its Components
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Metadata
- Authors
- Babu, S., & Jayaraman, S.
- Venue
- Biomedicine & Pharmacotherapy
- Publisher
- Elsevier BV
- Published
- 2020-11
- Volume
- 131
- Pages
- 110702
- ISSN
- 0753-3322 (ISSN-L)
- OpenAlex
- W3082210969
- Cited by
- 658
- References
- 64
- FWCI
- 35.35
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
