Cited by 157Seaweed-derived Bioactive CompoundsHeme Oxygenase-1 and Carbon MonoxideMicrobial Metabolism and Applications

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Phycocyanin: Anti-inflammatory effect and mechanism

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Liu, Runze, Qin, Song, Li, Wenjun·2022·Biomedicine & Pharmacotherapy

DOI 10.1016/j.biopha.2022.113362

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Abstract

As the host defense response to various injuries and pathogens in the body, inflammation can remove damaged cells and pathogens in the host organism and protect the body. However, excessive inflammation may cause damage to normal tissue cells while removing pathogens, which in turn cause numerous inflammatory diseases and adversely affect the human health. Phycocyanin is an active substance extracted from algae; it has outstanding antioxidant and anti-inflammatory activities, and can effectively inhibit various diseases caused by inflammation. This review systematically summarizes recent applications of phycocyanin against various inflammatory diseases in lung, liver, cardiovascular, and cerebrovascular systems. In addition, possible anti-inflammatory action pathways of phycocyanin are reviewed to canvass the anti-inflammatory mechanism. At last, based on the existing research, phycocyanobilin in phycocyanin is proposed as a bilirubin analog by inducing heme oxygenase 1 in vivo to suppress inflammation.

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Authors: Liu, R., Qin, S., & Li, W.
Affiliations: Chinese Academy of Sciences (CN)
Corresponding author: Li, Wenjun
ORCID: Liu, Runze
Qin, Song
Li, Wenjun
Venue: Biomedicine & Pharmacotherapy
Publisher: Elsevier BV
Published: 2022-09
Volume: 153
Pages: 113362
ISSN: 0753-3322 (ISSN-L)
DOI: 10.1016/j.biopha.2022.113362
OpenAlex: W4285384602
Cited by: 157
References: 83
Citations by year: 2026: 52 · 2025: 50 · 2024: 40 · 2023: 14 · 2022: 1
FWCI: 2.23
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by-nc-nd/4.0/ (vor)
Locations: Biomedicine & Pharmacotherapy (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Knowledge Repository of Yantai Institute of Coastal Zone Research, CAS (Yantai Institute of Coastal Zone Research) (submittedVersion)
Funders: National Key Research and Development Program of China (2021YFC2103900)
Topics: Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heme Oxygenase-1 and Carbon Monoxide
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Microbial Metabolism and Applications
Keywords: phycocyanin, anti-inflammatory activity, inflammatory diseases, antioxidant activity, phycocyanobilin, heme oxygenase-1, inflammatory mechanisms, lung inflammation, liver inflammation, cardiovascular inflammation, cerebrovascular inflammation
MeSH terms: Anti-Inflammatory Agents, Antioxidants, Bilirubin, Humans, Inflammation, Phycocyanin

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