Small extracellular vesicles as potential theranostic tools in central nervous system disorders
Open accessAbstract
Small extracellular vesicles(sEVs), a subset of extracellular vesicles with a bilateral membrane structure, contain biological cargoes, such as lipids, nucleic acids, and proteins. sEVs are crucial mediators of intercellular communications in the physiological and pathological processes of the central nervous system. Because of the special structure and complex pathogenesis of the brain, central nervous system disorders are characterized by high mortality and morbidity. Increasing evidence has focused on the potential of sEVs in clinical application for central nervous system disorders. sEVs are emerging as a promising diagnostic and therapeutic tool with high sensitivity, low immunogenicity, superior safety profile, and high transfer efficiency. This review highlighted the development of sEVs in central nervous system disorder clinical application. We also outlined the role of sEVs in central nervous system disorders and discussed the limitations of sEVs in clinical translation.
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Integration of EVs with nanotechnology has enormous potential to overcome the limitations encountered when utilizing either approach alone in theranostics for CNS diseases.
“From this point of view, the integration of EVs with nanotechnology has enormous potential to overcome the limitations encountered when utilizing either approach alone in theranostics for CNS diseases [49–51].”
From Extracellular vesicles as nanotheranostic platforms for targeted neurological disorder interventions (2024) · cites this paper as [49]
Understanding the dual roles of EVs in maintaining neuronal homeostasis and contributing to neurodegenerative processes is crucial for developing early diagnosis methods and targeted therapeutic strategies.
“Understanding the dual roles of EVs in maintaining neuronal homeostasis and contributing to neurodegenerative processes is crucial for developing early diagnosis methods and targeted therapeutic strategies [49].”
From Extracellular vesicles as nanotheranostic platforms for targeted neurological disorder interventions (2024) · cites this paper as [49]
Cites
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Extracellular vesicles as nanotheranostic platforms for targeted neurological disorder interventions
Choi, H. K., Chen, M., Goldston, L. L., & Lee, K.-B. (2024) · Nano Convergence · doi:10.1186/s40580-024-00426-5 · Cited by 26 · see citing works
- Authors
- Guo, M., Wang, L., Yin, Z., Chen, F., & Lei, P.
- Affiliations
- Capital Medical University (CN)
- Tianjin Medical University General Hospital (CN)
- Corresponding author
- Chen, Fanglian
- Lei, Ping
- Venue
- Biomedicine & Pharmacotherapy
- Publisher
- Elsevier BV
- Published
- 2023-11
- Volume
- 167
- Pages
- 115407
- ISSN
- 0753-3322 (ISSN-L)
- OpenAlex
- W4386534725
- Cited by
- 4
- References
- 4
- Citations by year
- 2025: 2 · 2024: 2
- FWCI
- 0.11
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Biomedicine & Pharmacotherapy (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- National Natural Science Foundation of China (82072166, 82102318)
- Tianjin Municipal Science and Technology Program (20YFZCSY00030)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Caveolin-1 and cellular processes
- Keywords
- small extracellular vesicles, central nervous system disorders, theranostics, intercellular communication, biomarkers, neurodegenerative diseases, clinical translation, vesicle cargo, neuroinflammation
- MeSH terms
- Extracellular Vesicles, Theranostic Nanomedicine, Animals, Central Nervous System Diseases, Humans
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