Valproic acid preconditioning of bone marrow mesenchymal stem cells promotes remyelination of the corpus callosum in a cuprizone-induced demyelination model

Noorzehi, Golaleh; Pasbakhsh, Parichehr; Taghizadeh, Fatemeh; Alikarami, Ameneh; Kashani, Iraj Ragerdi; Mojaverrostami, Sina

doi:10.1016/j.biopha.2025.118027

Valproic acid preconditioning of bone marrow mesenchymal stem cells promotes remyelination of the corpus callosum in a cuprizone-induced demyelination model

Multiple sclerosis (MS) is an inflammatory demyelinating disorder that currently has no exact treatment. However, stem cell therapy shows promise in treating neurodegenerative disorders. One of the main challenges with this treatment is the high apoptosis rate and low migration capacity of the tr…