The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Milnacipran: a comparative analysis of human monoamine uptake and transporter binding affinity
Abstract
Background Though selective serotonin reuptake inhibitors have revolutionized the field of psychiatry with demonstrated efficacy in affective and anxiety disorders with minimal side effects, norepinephrine-serotonin reuptake inhibitors may provide efficacy similar to tricyclic antidepressants without the adverse side effects associated with tricyclic antidepressants. Methods The affinity and selectivity of milnacipran, duloxetine, venlafaxine, citalopram, amitriptyline, and nortriptyline were determined for the human serotonin, norepinephrine, and dopamine transporters. Results Both milnacipran and duloxetine were potent inhibitors of serotonin and norepinephrine uptake. Unlike duloxetine and venlafaxine, milnacipran appears serotonin transporter selective in binding (ratio = 2.61) and norepinephrine transporter selective in uptake (ratio =.45). Conclusions Milnacipran's binding and uptake inhibition profile more closely resembles that of the tricyclic antidepressants than that of duloxetine. Whether these differences observed in vitro manifest themselves in vivo is not clear.
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“DLX and MLN are serotonin (5HT) and norepinephrine (NE) reuptake inhibitors.”
From Comparative Efficacy and Harms of Duloxetine, Milnacipran, and Pregabalin in Fibromyalgia Syndrome (2010) · cites this paper as [64]
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“DLX has a 5:1 5HT/NE ratio and MLN has a 3:1 NE/5HT ratio.”
From Comparative Efficacy and Harms of Duloxetine, Milnacipran, and Pregabalin in Fibromyalgia Syndrome (2010) · cites this paper as [64]
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Citations
Cites
Pharmacological profile of antidepressants and related compounds at human monoamine transporters
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Self-citationOwens, M. J., Knight, D. L., & Nemeroff, C. B. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01145-3 · Cited by 518
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Inhibition of Norepinephrine Uptake in Patients With Major Depression Treated With Paroxetine
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Self-citationPreclinical pharmacology of milnacipran
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Metadata
- Authors
- Vaishnavi, S. N., Nemeroff, C. B., Plott, S. J., Rao, S. G., Kranzler, J., & Owens, M. J.
- Affiliations
- Emory University (US)
- Corresponding author
- Owens, Michael J
- ORCID
- Nemeroff, Charles B
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2004-02
- Volume
- 55
- Issue
- 3
- Pages
- 320-322
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2113447800
- Cited by
- 178
- References
- 15
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 4 · 2023: 6 · 2022: 7 · 2021: 3 · 2020: 5 · 2019: 5 · 2018: 5 · 2017: 6 · 2016: 5 · 2015: 12 · 2014: 6 · 2013: 13 · 2012: 11
- FWCI
- 4.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- milnacipran, serotonin transporter, norepinephrine transporter, dopamine transporter, uptake inhibition, duloxetine, venlafaxine, citalopram, amitriptyline, nortriptyline, tricyclic antidepressants
- MeSH terms
- Duloxetine Hydrochloride, Venlafaxine Hydrochloride, Milnacipran, Antidepressive Agents, Mental Disorders, Carrier Proteins, Cyclohexanols, Cyclopropanes, Humans, Membrane Glycoproteins, Nerve Tissue Proteins, Neurons, Norepinephrine, Serotonin, Thiophenes, Citalopram, Selective Serotonin Reuptake Inhibitors, Adrenergic Uptake Inhibitors, Membrane Transport Proteins, Symporters, Norepinephrine Plasma Membrane Transport Proteins, Serotonin Plasma Membrane Transport Proteins
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