CoChat
Sign Up
Cited by 21Treatment of Major DepressionNeurotransmitter Receptor Influence on BehaviorTryptophan and brain disorders

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

Serotonin Transporter Residual Availability During Long-Term Antidepressant Therapy Does Not Differentiate Responder and Nonresponder Unipolar Patients

Cavanagh, Jonathan, Patterson, James, Pimlott, Sally, Dewar, Deborah, Eersels, Jos, Dempsey, Mary Frances, Wyper, David·2006·Biological Psychiatry
DOI 10.1016/j.biopsych.2005.06.029
Open this paper in CoChat — free account

Abstract

Background Serotonin transporters (SERT) are a major target for antidepressant medication, although there have been limited in vivo studies of SERT availability in patients being treated with antidepressants. It is not known whether SERT availability differs in treatment-responsive and -nonresponsive patients receiving long-term treatment. In this study, we used single photon emission computed tomography (SPECT) to compare SERT residual availability in unipolar responders and nonresponders during long-term antidepressant treatment. Dopamine transporter (DAT) availability was also assessed in the same patients to examine the relationship between the two transporter systems. Methods Twenty-four medicated unipolar patients were recruited, of whom 11 were responders and 13 were nonresponders. All patients underwent SPECT with [123I] beta-carbomethoxy-3-beta-(4 iodophenyl)tropane. Brain SERT was measured in the brain stem and diencephalon, and DAT was measured in the striatum. Residual availability was calculated as a ratio of specific to nonspecific uptake, with the occipital region used as the nonspecific reference region. Results There was no difference between responders and nonresponders in SERT availability. Dopamine transporter availability was similar in responders and nonresponders, and there was no association between SERT and DAT availability. Conclusions Serotonin transporter availability does not discriminate responders and nonresponders during long-term treatment with antidepressants.

Overview

Integrity signals

Registry

Crossref · 10.1016/j.biopsych.2005.06.029

Cites

3 of 3 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Flagged first, then by citations

Research works printed but not linked: 43

  1. Al-Tikriti, 1995, Characterization of the dopamine transporter in nonhuman primate brain, Nucl Med Biol, 22, 649, 10.1016/0969-8051(94)00140-F · DOI
  2. Baldwin, 1993, Evaluation of the monoamine uptake site ligand [123I]methyl 3 beta-(4-iodophenyl)-tropane-2 beta-carboxylate ([123I]beta-CIT) in non-human primates, Nucl Med Biol, 20, 597, 10.1016/0969-8051(93)90028-S · DOI
  3. Barnes, 2000, The use of Statistical Parametric Mapping (SPM96) as a decision aid in the differential diagnosis of dementia using 99mTc-HMPAO SPECT, Behav Neurol, 12, 77, 10.1155/2000/482606 · DOI
  4. Beique, 1998, Affinities of venlafaxine and various reuptake inhibitors for the serotonin and norepinephrine transporters, Eur J Pharmacol, 349, 129, 10.1016/S0014-2999(98)00241-6 · DOI
  5. Benmansour, 1999, Effects of chronic antidepressant treatments on serotonin transporter function, density, and mRNA level, J Neurosci, 19, 10494, 10.1523/JNEUROSCI.19-23-10494.1999 · DOI
  6. Benmansour, 2002, Serotonin clearance in vivo is altered to a greater extent by antidepressant-induced downregulation of the serotonin transporter than by acute blockade of this transporter, J Neurosci, 22, 6766, 10.1523/JNEUROSCI.22-15-06766.2002 · DOI
  7. Berding, 2003, [[123I]beta-CIT SPECT imaging of dopamine and serotonin transporters in Parkinson’s disease and multiple system atrophy], Nuklearmedizin, 42, 31, 10.1055/s-0038-1623903 · DOI
  8. Bois, 2004, Synthesis and monoamine transporter affinity of 3’-analogs of 2-beta-carbomethoxy-3-beta-(4’-iodophenyl)tropane (beta-CIT), Bioorg Med Chem Lett, 3, 2117, 10.1016/j.bmcl.2004.02.043 · DOI
  9. Brunswick, 2003, Greater availability of brain dopamine transporters in major depression shown by [99mTc]TRODAT-1 SPECT imaging, Am J Psychiatry, 160, 1836, 10.1176/appi.ajp.160.10.1836 · DOI · Paper page
  10. Brücke, 1993, SPECT imaging of dopamine and serotonin transporters with [123I]beta-CIT. Binding kinetics in the human brain, J Neural Transm Gen Sect, 94, 137, 10.1007/BF01245007 · DOI
  11. de Win, 2005, Validation of [123I]beta-CIT SPECT to assess serotonin transporters in vivo in humans, Neuropsychopharmacology, 30, 996, 10.1038/sj.npp.1300683 · DOI
  12. Farde, 1994, PET study of [11C]beta-CIT binding to monoamine transporters in the monkey and human brain, Synapse, 16, 93, 10.1002/syn.890160203 · DOI
  13. Fujita, 1996, Differential kinetics of [123I]beta-CIT binding to dopamine and serotonin transporters, Eur J Nucl Med, 23, 431, 10.1007/BF01247372 · DOI
  14. Haapaniemi, 2001, [123I]beta-CIT SPECT demonstrates decreased brain dopamine and serotonin transporter levels in untreated parkinsonian patients, Mov Disord, 16, 124, 10.1002/1531-8257(200101)16:1<124::AID-MDS1007>3.0.CO;2-R · DOI
  15. Hebert, 2001, Effects of chronic antidepressant treatments on 5-HT and NA transporters in rat brain, Neurochem Int, 38, 63, 10.1016/S0197-0186(00)00043-7 · DOI
  16. Hesse, 2003, Is correction for age necessary in neuroimaging studies of the central serotonin transporter system?, Eur J Nucl Med, 30, 427, 10.1007/s00259-002-1044-6 · DOI
  17. Hollon, 2005, Prevention of relapse following cognitive therapy vs medications in moderate to severe depression, Arch Gen Psychiatry, 62, 417, 10.1001/archpsyc.62.4.417 · DOI · Paper page
  18. Innis, 1991, Single photon emission computed tomography imaging of monoamine reuptake sites in primate brain with [123I]CIT, Eur J Pharmacol, 200, 369, 10.1016/0014-2999(91)90599-L · DOI
  19. Kakiuchi, 2001, Effects of aging on serotonin transporter availability and its response to fluvoxamine in the living brain, Synapse, 40, 170, 10.1002/syn.1039 · DOI
  20. Kent, 2002, Occupancy of brain serotonin transporters during treatment with paroxetine in patients with social phobia, Psychopharmacology, 164, 341, 10.1007/s00213-002-1218-8 · DOI
  21. Kugaya, 2004, Brain SERT availability predicts treatment response to SSRIs, Biol Psychiatry, 56, 497, 10.1016/j.biopsych.2004.07.001 · DOI
  22. Kugaya, 2003, Changes in human in vivo serotonin and dopamine transporter availabilities during chronic antidepressant administration, Neuropsychopharmacology, 28, 413, 10.1038/sj.npp.1300036 · DOI
  23. Kuikka, 1993, Initial experience with single-photon emission tomography using iodine-123-labelled 2 beta-carbomethoxy-3 beta-(4-iodophenyl) tropane in human brain, Eur J Nucl Med, 20, 783, 10.1007/BF00180909 · DOI
  24. Kuikka, 2001, Effects of ageing on serotonin transporters in healthy females, Eur J Nucl Med, 28, 911, 10.1007/s002590100540 · DOI
  25. Laasonen-Balk, 1999, Striatal dopamine transporter density in major depression, Psychopharmacology (Berl), 144, 282, 10.1007/s002130051005 · DOI
  26. Laruelle, 1993, SPECT imaging of dopamine and serotonin transporters with [123I]beta-CIT, Synapse, 13, 295, 10.1002/syn.890130402 · DOI
  27. Laruelle, 1994, Graphical, kinetic, and equilibrium analyses of in vivo [123I]beta-CIT binding to dopamine transporters in healthy human subjects, J Cereb Blood Flow Metab, 14, 982, 10.1038/jcbfm.1994.131 · DOI
  28. Lavalaye, 2000, Effect of age and gender on dopamine transporter imaging with [123I]FP-CIT SPET in healthy volunteers, Eur J Nucl Med, 27, 867, 10.1007/s002590000279 · DOI
  29. Meyer, 2001, Occupancy of serotonin transporters by paroxetine and citalopram during treatment of depression, Am J Psychiatry, 158, 1843, 10.1176/appi.ajp.158.11.1843 · DOI
  30. Okada, 1998, Assessment of affinities of beta-CIT, beta-CIT-FE, and beta-CIT-FP for monoamine transporters permanently expressed in cell lines, Nucl Med Biol, 25, 53, 10.1016/S0969-8051(97)00156-X · DOI
  31. Pirker, 2000, Imaging serotonin and dopamine transporters with 123I-beta-CIT SPECT, J Nucl Med, 41, 36
  32. Pirker, 1995, Beta-CIT SPECT demonstrates blockade of 5HT-uptake sites by citalopram in the human brain in vivo, J Neural Transm Gen Sect, 100, 247, 10.1007/BF01276462 · DOI
  33. Sackeim, 2001, The definition and meaning of treatment resistant depression, J Clin Psychiatry, 62, 10
  34. Staley, 1994, Visualizing dopamine and serotonin transporters in the human brain with the potent cocaine analogue [125I]RTI-55, J Neurochem, 62, 549, 10.1046/j.1471-4159.1994.62020549.x · DOI
  35. Suhara, 2003, High levels of SERT occupancy with low dose clomipramine in comparative occupancy study with fluvoxamine using PET, Arch Gen Psychiatry, 60, 386, 10.1001/archpsyc.60.4.386 · DOI
  36. Tatsumi, 1997, Pharmacological profile of antidepressants and related compounds at human monoamine transporters, Eur J Pharmacol, 340, 249, 10.1016/S0014-2999(97)01393-9 · DOI · Paper page
  37. Tauscher, 1999, In vivo visualization of serotonin transporters in the human brain during fluoxetine treatment, Eur Neuropsychopharmacol, 9, 177, 10.1016/S0924-977X(98)00013-3 · DOI
  38. Tiihonen, 1997, Single-photon emission tomography imaging of monoamine transporters in impulsive violent behaviour, Eur J Nucl Med, 24, 1253, 10.1007/s002590050149 · DOI
  39. van Dyck, 2000, Age-related decline in central serotonin transporter availability with beta-CIT, Neurobiol Aging, 21, 497, 10.1016/S0197-4580(00)00152-4 · DOI
  40. van Dyck, 1995, Age-related decline in striatal dopamine transporter binding with iodine-123-beta-CIT SPECT, J Nucl Med, 36, 1175
  41. Volkow, 1996, Measuring age-related changes in dopamine D2 receptors with 11C-raclopride and 18F-N-methylspiroperidol, Psychiatry Res, 67, 11, 10.1016/0925-4927(96)02809-0 · DOI
  42. Yamamoto, 2002, Age-related decline of serotonin transporters in living human brain of healthy males, Life Sci, 71, 751, 10.1016/S0024-3205(02)01745-9 · DOI
  43. Yau, 1999, Chronic amitriptyline administration increases serotonin transporter binding sites in the hippocampus of aged rats, Neurosci Lett, 261, 183, 10.1016/S0304-3940(98)00997-5 · DOI

Cited by

Sorted by citations

Metadata

Authors
Cavanagh, J., Patterson, J., Pimlott, S., Dewar, D., Eersels, J., Dempsey, M. F., & Wyper, D.
Affiliations
  • Southern General Hospital (GB)
  • National Health Service (GB)
  • University of Glasgow (GB)
  • Vrije Universiteit Amsterdam (NL)
Corresponding author
Cavanagh, Jonathan
ORCID
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
2006-02
Volume
59
Issue
4
Pages
301-308
ISSN
0006-3223 (ISSN-L)
DOI
10.1016/j.biopsych.2005.06.029
OpenAlex
W2090548503
Cited by
21
References
3
Citations by year
2025: 1 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 1 · 2018: 1 · 2015: 1 · 2014: 1 · 2013: 1 · 2012: 2
FWCI
1.27
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • VUBIR (Vrije Universiteit Brussel) (submittedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords
serotonin transporter, antidepressant response, major depressive disorder, dopamine transporter, [123I]beta-CIT, SPECT, striatum, brainstem, diencephalon
MeSH terms
Venlafaxine Hydrochloride, Mirtazapine, Adult, Aging, Antidepressive Agents, Antidepressive Agents, Tricyclic, Cyclohexanols, Depressive Disorder, Female, Humans, Image Processing, Computer-Assisted, Male, Mianserin, Middle Aged, Tropanes, Tomography, Emission-Computed, Single-Photon, Selective Serotonin Reuptake Inhibitors, Radiopharmaceuticals, Serotonin Plasma Membrane Transport Proteins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review